Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio
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Title
Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio
Authors
Keywords
-
Journal
Cell Discovery
Volume 2, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-08-23
DOI
10.1038/celldisc.2016.26
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Note: Only part of the references are listed.- γ-Secretase Catalyzes Sequential Cleavages of the AβPP Transmembrane Domain
- (2017) Xuemin Xu JOURNAL OF ALZHEIMERS DISEASE
- Precise gene deletion and replacement using the CRISPR/Cas9 system in human cells
- (2016) Qiupeng Zheng et al. BIOTECHNIQUES
- An atomic structure of human γ-secretase
- (2015) Xiao-chen Bai et al. NATURE
- Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
- (2015) Yanyong Kang et al. NATURE
- Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain
- (2015) David M. Bolduc et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH
- (2015) Shangyu Dang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis of human γ-secretase assembly
- (2015) Linfeng Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Three-dimensional structure of human γ-secretase
- (2014) Peilong Lu et al. NATURE
- Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions
- (2013) Fredrik Olsson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production
- (2013) Marc Suárez-Calvet et al. JOURNAL OF NEUROCHEMISTRY
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Scalable web services for the PSIPRED Protein Analysis Workbench
- (2013) Daniel W. A. Buchan et al. NUCLEIC ACIDS RESEARCH
- Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes
- (2013) Yi Li et al. STRUCTURE
- Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production
- (2013) Mitko Dimitrov et al. Nature Communications
- Neuropathological Alterations in Alzheimer Disease
- (2013) A. Serrano-Pozo et al. Cold Spring Harbor Perspectives in Medicine
- Differential Effects between -Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice
- (2012) Y. Mitani et al. JOURNAL OF NEUROSCIENCE
- The Molecular Pathology of Alzheimer's Disease
- (2012) Charles R. Harrington NEUROIMAGING CLINICS OF NORTH AMERICA
- The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol
- (2012) P. J. Barrett et al. SCIENCE
- Current and future treatments for Alzheimer’s disease
- (2012) Konstantina G. Yiannopoulou et al. Therapeutic Advances in Neurological Disorders
- Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40Ratios in Alzheimer Disease
- (2011) Kris Pauwels et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- APP processing in Alzheimer's disease
- (2011) Yun-wu Zhang et al. Molecular Brain
- Acute -Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid- Production to Alternative APP Fragments without Amyloid- Rebound
- (2010) J. J. Cook et al. JOURNAL OF NEUROSCIENCE
- The secretases: enzymes with therapeutic potential in Alzheimer disease
- (2010) Bart De Strooper et al. Nature Reviews Neurology
- Preclinical Profile of a Potent -Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
- (2009) L. Luistro et al. CANCER RESEARCH
- -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of -Carboxyl Terminal Fragment
- (2009) M. Takami et al. JOURNAL OF NEUROSCIENCE
- An Overview of APP Processing Enzymes and Products
- (2009) Vivian W. Chow et al. NEUROMOLECULAR MEDICINE
- Substrate specificity of γ-secretase and other intramembrane proteases
- (2008) A. J. Beel et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Reassessing the amyloid cascade hypothesis of Alzheimer's disease
- (2008) Sanjay W. Pimplikar INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
- (2003) H. F. Dovey et al. JOURNAL OF NEUROCHEMISTRY
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