Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction

PDEδ Binding to Ras Isoforms Provides a Route to Proper Membrane Localization

(2017) Serena Muratcioglu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Computational Modeling Reveals that Signaling Lipids Modulate the Orientation of K-Ras4A at the Membrane Reflecting Protein Topology

(2017) Zhen-Lu Li et al.   STRUCTURE

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers

(2016) H. Jang et al.   BIOCHEMICAL JOURNAL

Regulation of K-Ras4B Membrane Binding by Calmodulin

(2016) Benjamin Sperlich et al.   BIOPHYSICAL JOURNAL

Ras Conformational Ensembles, Allostery, and Signaling

(2016) Shaoyong Lu et al.   CHEMICAL REVIEWS

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

(2016) Shaoyong Lu et al.   CHEMICAL SOCIETY REVIEWS

K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?

(2016) Ruth Nussinov et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The higher level of complexity of K-Ras4B activation at the membrane

(2016) Hyunbum Jang et al.   FASEB JOURNAL

Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences

(2016) Mayukh Chakrabarti et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Probing conformational and functional substates of calmodulin by high pressure FTIR spectroscopy: influence of Ca2+ binding and the hypervariable region of K-Ras4B

(2016) Nelli Erwin et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation

(2016) Ruth Nussinov et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Comparison of liver oncogenic potential among human RAS isoforms

(2016) Sook In Chung et al.   Oncotarget

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B

(2016) Shaoyong Lu et al.   Scientific Reports

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

(2015) Tanmay S. Chavan et al.   BIOPHYSICAL JOURNAL

A New View of Ras Isoforms in Cancers

(2015) R. Nussinov et al.   CANCER RESEARCH

The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities

(2015) Samuel Genheden et al.   Expert Opinion on Drug Discovery

Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region

(2015) Hyunbum Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

(2015) Shaoyong Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

(2015) R. Nussinov et al.   MOLECULAR CANCER RESEARCH

GTP-Dependent K-Ras Dimerization

(2015) Serena Muratcioglu et al.   STRUCTURE

Absolute Quantification of Endogenous Ras Isoform Abundance

(2015) Craig J. Mageean et al.   PLoS One

KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular Transport

(2014) Malte Schmick et al.   CELL

The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer

(2013) Martin W. Berchtold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Application of Reductive 13C-Methylation of Lysines to Enhance the Sensitivity of Conventional NMR Methods

(2013) Tanmay Chavan et al.   MOLECULES

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

(2012) Bill R. Miller et al.   Journal of Chemical Theory and Computation

Dissociation of the K-Ras4B/PDEδ Complex upon Contact with Lipid Membranes: Membrane Delivery Instead of Extraction

(2012) Katrin Weise et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Free Energy Calculations by the Molecular Mechanics Poisson−Boltzmann Surface Area Method

(2012) Nadine Homeyer et al.   Molecular Informatics

Structural Basis for Calmodulin as a Dynamic Calcium Sensor

(2012) Miao Zhang et al.   STRUCTURE

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

(2011) Anchal Chandra et al.   NATURE CELL BIOLOGY

Both the C-Terminal Polylysine Region and the Farnesylation of K-RasB Are Important for Its Specific Interaction with Calmodulin

(2011) Ling-Jia Wu et al.   PLoS One

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

The Hypervariable Region of K-Ras4B Is Responsible for Its Specific Interactions with Calmodulin

(2009) Sherwin J. Abraham et al.   BIOCHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Identification of Essential Interacting Elements in K-Ras/Calmodulin Binding and Its Role in K-Ras Localization

(2008) Cristina Lopez-Alcalá et al.   JOURNAL OF BIOLOGICAL CHEMISTRY