Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction
出版年份 2017 全文链接
标题
Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction
作者
关键词
-
出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 30, Pages 12544-12559
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2017-06-17
DOI
10.1074/jbc.m117.785063
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- PDEδ Binding to Ras Isoforms Provides a Route to Proper Membrane Localization
- (2017) Serena Muratcioglu et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Computational Modeling Reveals that Signaling Lipids Modulate the Orientation of K-Ras4A at the Membrane Reflecting Protein Topology
- (2017) Zhen-Lu Li et al. STRUCTURE
- Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers
- (2016) H. Jang et al. BIOCHEMICAL JOURNAL
- Regulation of K-Ras4B Membrane Binding by Calmodulin
- (2016) Benjamin Sperlich et al. BIOPHYSICAL JOURNAL
- Ras Conformational Ensembles, Allostery, and Signaling
- (2016) Shaoyong Lu et al. CHEMICAL REVIEWS
- Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view
- (2016) Shaoyong Lu et al. CHEMICAL SOCIETY REVIEWS
- K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?
- (2016) Ruth Nussinov et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The higher level of complexity of K-Ras4B activation at the membrane
- (2016) Hyunbum Jang et al. FASEB JOURNAL
- Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences
- (2016) Mayukh Chakrabarti et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Probing conformational and functional substates of calmodulin by high pressure FTIR spectroscopy: influence of Ca2+ binding and the hypervariable region of K-Ras4B
- (2016) Nelli Erwin et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation
- (2016) Ruth Nussinov et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Comparison of liver oncogenic potential among human RAS isoforms
- (2016) Sook In Chung et al. Oncotarget
- The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B
- (2016) Shaoyong Lu et al. Scientific Reports
- High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site
- (2015) Tanmay S. Chavan et al. BIOPHYSICAL JOURNAL
- A New View of Ras Isoforms in Cancers
- (2015) R. Nussinov et al. CANCER RESEARCH
- The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities
- (2015) Samuel Genheden et al. Expert Opinion on Drug Discovery
- Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region
- (2015) Hyunbum Jang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site
- (2015) Shaoyong Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
- (2015) R. Nussinov et al. MOLECULAR CANCER RESEARCH
- GTP-Dependent K-Ras Dimerization
- (2015) Serena Muratcioglu et al. STRUCTURE
- Absolute Quantification of Endogenous Ras Isoform Abundance
- (2015) Craig J. Mageean et al. PLoS One
- KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular Transport
- (2014) Malte Schmick et al. CELL
- The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer
- (2013) Martin W. Berchtold et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Application of Reductive 13C-Methylation of Lysines to Enhance the Sensitivity of Conventional NMR Methods
- (2013) Tanmay Chavan et al. MOLECULES
- A Comprehensive Survey of Ras Mutations in Cancer
- (2012) I. A. Prior et al. CANCER RESEARCH
- MMPBSA.py: An Efficient Program for End-State Free Energy Calculations
- (2012) Bill R. Miller et al. Journal of Chemical Theory and Computation
- Dissociation of the K-Ras4B/PDEδ Complex upon Contact with Lipid Membranes: Membrane Delivery Instead of Extraction
- (2012) Katrin Weise et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Free Energy Calculations by the Molecular Mechanics Poisson−Boltzmann Surface Area Method
- (2012) Nadine Homeyer et al. Molecular Informatics
- Structural Basis for Calmodulin as a Dynamic Calcium Sensor
- (2012) Miao Zhang et al. STRUCTURE
- The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins
- (2011) Anchal Chandra et al. NATURE CELL BIOLOGY
- Both the C-Terminal Polylysine Region and the Farnesylation of K-RasB Are Important for Its Specific Interaction with Calmodulin
- (2011) Ling-Jia Wu et al. PLoS One
- Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations
- (2010) Tingjun Hou et al. Journal of Chemical Information and Modeling
- The Hypervariable Region of K-Ras4B Is Responsible for Its Specific Interactions with Calmodulin
- (2009) Sherwin J. Abraham et al. BIOCHEMISTRY
- CHARMM: The biomolecular simulation program
- (2009) B. R. Brooks et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Identification of Essential Interacting Elements in K-Ras/Calmodulin Binding and Its Role in K-Ras Localization
- (2008) Cristina Lopez-Alcalá et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started