GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

Divergent Roles of CAAXMotif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases

(2015) Leanna R. Gentry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme

(2015) Chris R. Evelyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region

(2015) Hyunbum Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

(2015) Xiaolin Nan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation

(2015) Shaoyong Lu et al.   STRUCTURE

GTP-Dependent K-Ras Dimerization

(2015) Serena Muratcioglu et al.   STRUCTURE

Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD

(2015) Susan K. Fetics et al.   STRUCTURE

The Renaissance of Ras

(2014) Lech-Gustav Milroy et al.   ACS Chemical Biology

The Chaperone Protein SmgGDS Interacts with Small GTPases Entering the Prenylation Pathway by Recognizing the Last Amino Acid in the CAAXMotif

(2014) Nathan J. Schuld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Efficacy of Raf Kinase Recruitment to the GTPase H-ras Depends on H-ras Membrane Conformer-specific Nanoclustering

(2014) Camilo Guzmán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Harnessing Allostery: A Novel Approach to Drug Discovery

(2014) Shaoyong Lu et al.   MEDICINAL RESEARCH REVIEWS

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

The Structural Basis of ATP as an Allosteric Modulator

(2014) Shaoyong Lu et al.   PLoS Computational Biology

A Unified View of “How Allostery Works”

(2014) Chung-Jung Tsai et al.   PLoS Computational Biology

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

‘Pathway drug cocktail’: targeting Ras signaling based on structural pathways

(2013) Ruth Nussinov et al.   TRENDS IN MOLECULAR MEDICINE

Metal-Bis(2-picolyl)amine Complexes as State 1(T) Inhibitors of Activated Ras Protein

(2012) Ina C. Rosnizeck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

(2012) Qi Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization, dynamics, and segregation of Ras nanoclusters in membrane domains

(2012) L. Janosi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure of the State 1 Conformer of GTP-bound H-Ras Protein and Distinct Dynamic Properties between the State 1 and State 2 Conformers

(2011) Mitsugu Araki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activating K-Ras mutations outwith ‘hotspot’ codons in sporadic colorectal tumours – implications for personalised cancer medicine

(2010) G Smith et al.   BRITISH JOURNAL OF CANCER

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

(2010) Fumi Shima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

(2010) Wen-I Wu et al.   PLoS One

Expression, purification, and characterization of soluble K-Ras4B for structural analysis

(2010) Sherwin J. Abraham et al.   PROTEIN EXPRESSION AND PURIFICATION

The Hypervariable Region of K-Ras4B Is Responsible for Its Specific Interactions with Calmodulin

(2009) Sherwin J. Abraham et al.   BIOCHEMISTRY

Crystallographic and Biochemical Analysis of the Ran-binding Zinc Finger Domain

(2009) James R. Partridge et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

(2009) Lei Chen et al.   NATURE

Membrane binding of lipidated Ras peptides and proteins — The structural point of view

(2008) Luc Brunsveld et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES