The higher level of complexity of K-Ras4B activation at the membrane

The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer

(2015) Sunny Guin et al.   ACTA PHARMACOLOGICA SINICA

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

(2015) Tanmay S. Chavan et al.   BIOPHYSICAL JOURNAL

Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region

(2015) Hyunbum Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

(2015) Shaoyong Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

(2015) Mohammad T. Mazhab-Jafari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

(2015) Frederick D. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTP-Dependent K-Ras Dimerization

(2015) Serena Muratcioglu et al.   STRUCTURE

Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs

(2014) Hyunbum Jang et al.   CHEMICAL SOCIETY REVIEWS

Activity and Architecture of Pyroglutamate-Modified Amyloid-β (AβpE3-42) Pores

(2014) Alan L. Gillman et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Topology of the Yeast Ras Converting Enzyme As Inferred from Cysteine Accessibility Studies

(2013) Emily R. Hildebrandt et al.   BIOCHEMISTRY

Mechanism of Membrane Permeation Induced by Synthetic β-Hairpin Peptides

(2013) Kshitij Gupta et al.   BIOPHYSICAL JOURNAL

Familial Alzheimer’s Disease Osaka Mutant (ΔE22) β-Barrels Suggest an Explanation for the Different Aβ1–40/42 Preferred Conformational States Observed by Experiment

(2013) Hyunbum Jang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Probing Structural Features of Alzheimer’s Amyloid-β Pores in Bilayers Using Site-Specific Amino Acid Substitutions

(2012) Ricardo Capone et al.   BIOCHEMISTRY

Effects of Point Substitutions on the Structure of Toxic Alzheimer’s β-Amyloid Channels: Atomic Force Microscopy and Molecular Dynamics Simulations

(2012) Laura Connelly et al.   BIOCHEMISTRY

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers

(2012) Ricardo Capone et al.   Journal of Chemical Theory and Computation

Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane

(2012) Hyunbum Jang et al.   Journal of Chemical Theory and Computation

Atomic Force Microscopy and MD Simulations Reveal Pore-Like Structures of All-d-Enantiomer of Alzheimer’s β-Amyloid Peptide: Relevance to the Ion Channel Mechanism of AD Pathology

(2012) Laura Connelly et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antimicrobial Protegrin-1 Forms Ion Channels: Molecular Dynamic Simulation, Atomic Force Microscopy, and Electrical Conductance Studies

(2010) Ricardo Capone et al.   BIOPHYSICAL JOURNAL

Segregation of Negatively Charged Phospholipids by the Polycationic and Farnesylated Membrane Anchor of Kras

(2010) Lorant Janosi et al.   BIOPHYSICAL JOURNAL

β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Convergence Among Diverse, Toxic β-Sheet Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Truncated  -amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

(2010) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras membrane orientation and nanodomain localization generate isoform diversity

(2010) D. Abankwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Backbone conformational flexibility of the lipid modified membrane anchor of the human N-Ras protein investigated by solid-state NMR and molecular dynamics simulation

(2009) Alexander Vogel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Misfolded Amyloid Ion Channels Present Mobile β-Sheet Subunits in Contrast to Conventional Ion Channels

(2009) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

K3 Fragment of Amyloidogenic β2-Microglobulin Forms Ion Channels: Implication for Dialysis Related Amyloidosis

(2009) Mirela Mustata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane binding of lipidated Ras peptides and proteins — The structural point of view

(2008) Luc Brunsveld et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Models of Toxic β-Sheet Channels of Protegrin-1 Suggest a Common Subunit Organization Motif Shared with Toxic Alzheimer β-Amyloid Ion Channels

(2008) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain

(2008) Alex J. Laude et al.   JOURNAL OF CELL SCIENCE

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How to lose a kink and gain a helix: pH independent conformational changes of the fusion domains from influenza hemagglutinin in heterogeneous lipid bilayers

(2008) Hyunbum Jang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS