Prediction of skin sensitization potency using machine learning approaches

Multivariate models for prediction of human skin sensitization hazard

(2016) Judy Strickland et al.   JOURNAL OF APPLIED TOXICOLOGY

Integrated decision strategies for skin sensitization hazard

(2016) Judy Strickland et al.   JOURNAL OF APPLIED TOXICOLOGY

Can currently available non-animal methods detect pre and pro-haptens relevant for skin sensitization?

(2016) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy

(2015) Joanna S. Jaworska et al.   ARCHIVES OF TOXICOLOGY

Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships

(2015) Thomas Luechtefeld et al.   JOURNAL OF APPLIED TOXICOLOGY

Evaluation of combinations ofin vitrosensitization test descriptors for the artificial neural network-based risk assessment model of skin sensitization

(2015) Morihiko Hirota et al.   JOURNAL OF APPLIED TOXICOLOGY

Test battery with the human cell line activation test, direct peptide reactivity assay and DEREK based on a 139 chemical data set for predicting skin sensitizing potential and potency of chemicals

(2015) Osamu Takenouchi et al.   JOURNAL OF APPLIED TOXICOLOGY

Assessing skin sensitization hazard in mice and men using non-animal test methods

(2015) Daniel Urbisch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

(2015) Kerstin Reisinger et al.   TOXICOLOGY IN VITRO

Correlation between experimental human and murine skin sensitization induction thresholds

(2014) Anne Marie Api et al.   Cutaneous and Ocular Toxicology

Categorization of Chemicals According to Their Relative Human Skin Sensitizing Potency

(2014) David A. Basketter et al.   Dermatitis

Towards AOP application – Implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization

(2014) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals

(2014) Jochem W. van der Veen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Predicting Skin Sensitizer Potency Based on In Vitro Data from KeratinoSens and Kinetic Peptide Binding: Global Versus Domain-Based Assessment

(2014) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

Skin sensitization risk assessment model using artificial neural network analysis of data from multiple in vitro assays

(2014) Kyoko Tsujita-Inoue et al.   TOXICOLOGY IN VITRO

Integrating non-animal test information into an adaptive testing strategy – skin sensitization proof of concept case

(2014) Joanna Jaworska   ALTEX-Alternatives to Animal Experimentation

Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network

(2014) Jason R. Pirone   ALTEX-Alternatives to Animal Experimentation

Occupational and non-occupational allergic contact dermatitis and quality of life: a prospective study

(2013) Catiussa Spode Brutti et al.   ANAIS BRASILEIROS DE DERMATOLOGIA

Occupational and Non-Occupational Allergic Contact Dermatitis: A Follow-Up Study

(2013) Jelena Macan et al.   DERMATOLOGY

Integrated testing and assessment approaches for skin sensitization: a commentary

(2013) David W. Roberts et al.   JOURNAL OF APPLIED TOXICOLOGY

Binary Classification of a Large Collection of Environmental Chemicals from Estrogen Receptor Assays by Quantitative Structure–Activity Relationship and Machine Learning Methods

(2013) Qingda Zang et al.   Journal of Chemical Information and Modeling

Predictive performance of the human Cell Line Activation Test (h-CLAT) for lipophilic chemicals with high octanol-water partition coefficients

(2013) Osamu Takenouchi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Non-animal test methods for predicting skin sensitization potentials

(2012) Annette Mehling et al.   ARCHIVES OF TOXICOLOGY

Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials

(2012) Caroline Bauch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Prediction of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt at classifying skin sensitization potency

(2012) Yuko Nukada et al.   TOXICOLOGY IN VITRO

Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals

(2012) Yuko Nukada et al.   TOXICOLOGY IN VITRO

Identification of heparin samples that contain impurities or contaminants by chemometric pattern recognition analysis of proton NMR spectral data

(2011) Qingda Zang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A Comprehensive Support Vector Machine Binary hERG Classification Model Based on Extensive but Biased End Point hERG Data Sets

(2011) Meng-yu Shen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predictive performance for human skin sensitizing potential of the human cell line activation test (h-CLAT)

(2011) Yuko Nukada et al.   CONTACT DERMATITIS

Contact allergy to the 26 specific fragrance ingredients to be declared on cosmetic products in accordance with the EU cosmetics directive

(2011) Maria V. Heisterberg et al.   CONTACT DERMATITIS

A Classification Study of Respiratory Syncytial Virus (RSV) Inhibitors by Variable Selection with Random Forest

(2011) Ming Hao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluating the sensitization potential of surfactants: Integrating data from the local lymph node assay, guinea pig maximization test, and in vitro methods in a weight-of-evidence approach

(2011) Nicholas Ball et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals

(2011) Caroline Bauch et al.   TOXICOLOGY IN VITRO

Combining 1H NMR spectroscopy and chemometrics to identify heparin samples that may possess dermatan sulfate (DS) impurities or oversulfated chondroitin sulfate (OSCS) contaminants

(2010) Qingda Zang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

Chemical Allergy: Translating Biology into Hazard Characterization

(2010) I. Kimber et al.   TOXICOLOGICAL SCIENCES

Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro

(2010) Roger Emter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Predicting skin sensitization potential and inter-laboratory reproducibility of a human Cell Line Activation Test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials

(2010) Hitoshi Sakaguchi et al.   TOXICOLOGY IN VITRO

Nothing is perfect, not even the local lymph node assay: a commentary and the implications for REACH

(2009) David A. Basketter et al.   CONTACT DERMATITIS

Filling the Concept with Data: Integrating Data from Different In Vitro and In Silico Assays on Skin Sensitizers to Explore the Battery Approach for Animal-Free Skin Sensitization Testing

(2008) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

The Research Institute for Fragrance Materials’ human repeated insult patch test protocol

(2007) Valerie T. Politano et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY