Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications

Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target

(2015) Qiang Gao et al.   Oncotarget

Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression

(2015) Lijun Jia et al.   NEOPLASIA

Targeting the mTOR-DEPTOR Pathway by CRL E3 Ubiquitin Ligases: Therapeutic Application

(2015) Yongchao Zhao et al.   NEOPLASIA

MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells

(2014) Y. Gu et al.   BLOOD

The NEDD8-Activating Enzyme Inhibitor MLN4924 Disrupts Nucleotide Metabolism and Augments the Efficacy of Cytarabine

(2014) S. T. Nawrocki et al.   CLINICAL CANCER RESEARCH

Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways

(2014) K. Garcia et al.   MOLECULAR CANCER THERAPEUTICS

Sculpting the proteome with small molecules

(2014) Randall W King et al.   Nature Chemical Biology

Suppression of tumor angiogenesis by targeting the protein neddylation pathway

(2014) W-T Yao et al.   Cell Death & Disease

Disrupting Protein NEDDylation with MLN4924 Is a Novel Strategy to Target Cisplatin Resistance in Ovarian Cancer

(2013) S. T. Nawrocki et al.   CLINICAL CANCER RESEARCH

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

(2013) Pascal Genschik et al.   EMBO JOURNAL

Building and remodelling Cullin-RING E3 ubiquitin ligases

(2013) John R Lydeard et al.   EMBO REPORTS

Overcoming Platinum Resistance in Preclinical Models of Ovarian Cancer Using the Neddylation Inhibitor MLN4924

(2013) A. A. Jazaeri et al.   MOLECULAR CANCER THERAPEUTICS

c-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor

(2013) Wei Zuo et al.   MOLECULAR CELL

RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination

(2013) Teng Ma et al.   MOLECULAR CELL

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin

(2013) Hao Huang et al.   Nature Chemical Biology

Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication

(2013) A. Ballabeni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

(2012) Z. Luo et al.   CANCER RESEARCH

Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924

(2012) J. L. Blank et al.   CANCER RESEARCH

The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions

(2012) Orsolya Leidecker et al.   CELL CYCLE

Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells

(2012) D Yang et al.   CELL DEATH AND DIFFERENTIATION

MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy

(2012) Steffan T Nawrocki et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Understanding Cullin-RING E3 Biology through Proteomics-based Substrate Identification

(2012) J. Wade Harper et al.   MOLECULAR & CELLULAR PROTEOMICS

Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

(2012) Y. Kee et al.   MOLECULAR CANCER RESEARCH

WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells

(2012) C Mackintosh et al.   ONCOGENE

The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme

(2012) Dong Yang et al.   PLoS One

Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis

(2012) Y Zhao et al.   Cell Death & Disease

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

(2011) Roland Hjerpe et al.   BIOCHEMICAL JOURNAL

NEDD8 Pathways in Cancer, Sine Quibus Non

(2011) Ian R. Watson et al.   CANCER CELL

Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor

(2011) D. Wei et al.   CANCER RESEARCH

Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover

(2011) M. A. Milhollen et al.   CANCER RESEARCH

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

(2011) Derek F. Ceccarelli et al.   CELL

Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924

(2011) Hua Liao et al.   MOLECULAR & CELLULAR PROTEOMICS

Prevention of DNA re-replication in eukaryotic cells

(2011) L. N. Truong et al.   Journal of Molecular Cell Biology

The cullin protein family

(2011) Antonio Sarikas et al.   GENOME BIOLOGY

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia

(2010) R. T. Swords et al.   BLOOD

NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells

(2010) J. J. Lin et al.   CANCER RESEARCH

Validation of SAG/RBX2/ROC2 E3 Ubiquitin Ligase as an Anticancer and Radiosensitizing Target

(2010) L. Jia et al.   CLINICAL CANCER RESEARCH

RBX1 (RING Box Protein 1) E3 Ubiquitin Ligase Is Required for Genomic Integrity by Modulating DNA Replication Licensing Proteins

(2010) Lijun Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

(2010) James E. Brownell et al.   MOLECULAR CELL

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Bortezomib induces canonical nuclear factor- B activation in multiple myeloma cells

(2009) T. Hideshima et al.   BLOOD

ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and Senescence

(2009) L. Jia et al.   CANCER RESEARCH

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer

(2009) T. A. Soucy et al.   CLINICAL CANCER RESEARCH

Regulation of nucleolar signalling to p53 through NEDDylation of L11

(2009) Anders Sundqvist et al.   EMBO REPORTS

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Novel substrates and functions for the ubiquitin-like molecule NEDD8: Figure 1

(2008) Dimitris P. Xirodimas   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Ribosomal proteins are targets for the NEDD8 pathway

(2008) Dimitris P Xirodimas et al.   EMBO REPORTS