MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells

Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression

(2015) Lijun Jia et al.   NEOPLASIA

Proteasomal regulation of caspase-8 in cancer cell apoptosis

(2013) Michael V. Fiandalo et al.   APOPTOSIS

Regulation of c-Myc Ubiquitination Controls Chronic Myelogenous Leukemia Initiation and Progression

(2013) Linsey Reavie et al.   CANCER CELL

Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1

(2013) Y.-C. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation

(2013) Jia Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A

(2012) M. Pulvino et al.   BLOOD

The PI3K/Akt/mTOR signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells

(2012) Man-Tat Lau et al.   CANCER LETTERS

The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

(2012) Z. Luo et al.   CANCER RESEARCH

Ceramide Glycosylation by Glucosylceramide Synthase Selectively Maintains the Properties of Breast Cancer Stem Cells

(2012) Vineet Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control

(2012) A. Mocciaro et al.   JOURNAL OF CELL SCIENCE

Proteasome inhibition leads to dephosphorylation and downregulation of protein expression of members of the Akt/mTOR pathway in MCL

(2012) G Hutter et al.   LEUKEMIA

Molecular and Cellular Effects of NEDD8-Activating Enzyme Inhibition in Myeloma

(2012) D. W. McMillin et al.   MOLECULAR CANCER THERAPEUTICS

Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling

(2012) H.-s. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of RAS oncogenicity by acetylation

(2012) M. H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover

(2011) M. A. Milhollen et al.   CANCER RESEARCH

Targeting PI3K/mTOR Signaling in Cancer

(2011) B. M. Emerling et al.   CANCER RESEARCH

Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia

(2010) François B. Favier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells

(2010) J. J. Lin et al.   CANCER RESEARCH

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

(2010) Audrey Carriere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice

(2010) Chong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

(2010) James E. Brownell et al.   MOLECULAR CELL

Myeloma cells exhibit an increase in proteasome activity and an enhanced response to proteasome inhibition in the bone marrow microenvironment in vivo

(2009) Claire M. Edwards et al.   AMERICAN JOURNAL OF HEMATOLOGY

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase

(2009) Samiksha Katiyar et al.   EMBO REPORTS

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE