Modulation of AβPP and GSK3β by Endoplasmic Reticulum Stress and Involvement in Alzheimer’s Disease

GSK-3 Inhibitors: A Ray of Hope for the Treatment of Alzheimer's Disease?

(2017) Ana Martinez et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammation in Alzheimer's Disease and Mild Cognitive Impairment: A Field in Its Infancy

(2017) Edith G. McGeer et al.   JOURNAL OF ALZHEIMERS DISEASE

Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders

(2016) Yu Cai et al.   Autophagy

Impaired mitochondrial function due to familial Alzheimer's disease-causing presenilins mutants via Ca2+ disruptions

(2016) Patrick Toglia et al.   CELL CALCIUM

IRE1α Signaling Pathways Involved in Mammalian Cell Fate Determination

(2016) Jie Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration

(2016) Michelle C. Bell et al.   Current Alzheimer Research

Protein Folding and Misfolding, Endoplasmic Reticulum Stress in Neurodegenerative Diseases: in Trace of Novel Drug Targets

(2016) Botond Penke et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Endoplasmic reticulum stress mediates JNK-dependent IRS-1 serine phosphorylation and results in Tau hyperphosphorylation in amyloid β oligomer-treated PC12 cells and primary neurons

(2016) Xiao Zhang et al.   GENE

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology

(2016) Nobutaka Sakae et al.   JOURNAL OF NEUROSCIENCE

Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells

(2016) Li-ping Chen et al.   Neural Regeneration Research

The Neuroprotective Effects of Justicidin A on Amyloid Beta25–35-Induced Neuronal Cell Death Through Inhibition of Tau Hyperphosphorylation and Induction of Autophagy in SH-SY5Y Cells

(2016) Ming-Yao Gu et al.   NEUROCHEMICAL RESEARCH

Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer’s disease

(2016) Riqiang Yan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL

(2016) Valérie Plaisance et al.   PLoS One

Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

(2016) Shuman Zhang et al.   Alzheimers Research & Therapy

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

(2015) Wiep Scheper et al.   ACTA NEUROPATHOLOGICA

Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

(2015) Sandra I. Mota et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ca2+ dysregulation in the endoplasmic reticulum related to Alzheimer’s disease: A review on experimental progress and computational modeling

(2015) Jingyi Liang et al.   BIOSYSTEMS

Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?

(2015) Ana I. Placido et al.   CNS & Neurological Disorders-Drug Targets

Dysfunction of Endoplasmic Reticulum (ER) and Mitochondria (MT) in Alzheimer's Disease: The Role of the ER-MT Cross-Talk

(2015) Katalin Volgyi et al.   Current Alzheimer Research

Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer’s Disease

(2015) Wioletta Rozpedek et al.   CURRENT MEDICINAL CHEMISTRY

ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion

(2015) Kei Suga et al.   EXPERIMENTAL CELL RESEARCH

Amyloid-β precursor protein: Multiple fragments, numerous transport routes and mechanisms

(2015) Virgil Muresan et al.   EXPERIMENTAL CELL RESEARCH

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Endoplasmic Reticulum Stress–Induced IRE1α Activation Mediates Cross-Talk of GSK-3β and XBP-1 To Regulate Inflammatory Cytokine Production

(2015) Sena Kim et al.   JOURNAL OF IMMUNOLOGY

SIL1 Rescued Bip Elevation-Related Tau Hyperphosphorylation in ER Stress

(2015) Zan-Chao Liu et al.   MOLECULAR NEUROBIOLOGY

Synaptotagmins interact with APP and promote Aβ generation

(2015) Vivek Gautam et al.   Molecular Neurodegeneration

FXR1P is a GSK3β substrate regulating mood and emotion processing

(2015) Thomas Del’Guidice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses

(2015) Y Hotokezaka et al.   Cell Death & Disease

Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation

(2015) Eun Sun Jung et al.   Scientific Reports

Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

(2014) Federica Prati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

(2014) A.I. Plácido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells

(2014) Bingqian Liu et al.   CELL STRESS & CHAPERONES

Glycogen Synthase Kinase-3 as a Therapeutic Target for Cognitive Dysfunction in Neuropsychiatric Disorders

(2014) Olivia O’Leary et al.   CNS DRUGS

Plasma Amyloid-β Oligomers and Soluble Tumor Necrosis Factor Receptors as Potential Biomarkers of AD

(2014) Jinbiao Zhang et al.   Current Alzheimer Research

Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis

(2014) Hiroki Inoue et al.   FEBS LETTERS

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Approaches to a Multitargeting Drug Development: First Profiled 3- Ethoxycarbonyl-1-aza-9-oxafluorenes Representing a Perspective Compound Class Targeting Alzheimer Disease Relevant Kinases CDK1, CDK5 and GSK-3.β

(2014) Andreas Hilgeroth et al.   Medicinal Chemistry

Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells

(2014) Ana I. Plácido et al.   MOLECULAR NEUROBIOLOGY

Endoplasmic Reticulum Dysfunction in Alzheimer’s Disease

(2014) Jie-Qiong Li et al.   MOLECULAR NEUROBIOLOGY

Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries

(2014) Venkata Prasuja Nakka et al.   MOLECULAR NEUROBIOLOGY

The PERK-eIF2α signaling pathway is involved in TCDD-induced ER stress in PC12 cells

(2014) Zhiqing Duan et al.   NEUROTOXICOLOGY

Addicted to secrete – novel concepts and targets in cancer therapy

(2014) Nicolas Dejeans et al.   TRENDS IN MOLECULAR MEDICINE

The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress

(2014) J M van der Harg et al.   Cell Death & Disease

Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass

(2014) David J. Bonda et al.   Neuroscience Bulletin

Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease

(2014) Masuo Ohno   Frontiers in Molecular Neuroscience

Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease

(2013) Elena Alberdi et al.   AGING CELL

Glucose deprivation induces reticulum stress by the PERK pathway and caspase-7- and calpain-mediated caspase-12 activation

(2013) Selene García de la Cadena et al.   APOPTOSIS

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells

(2013) Ana Catarina R.G. Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease

(2013) Annalisa Cavallini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNF13, a RING Finger Protein, Mediates Endoplasmic Reticulum Stress-induced Apoptosis through the Inositol-requiring Enzyme (IRE1α)/c-Jun NH2-terminal Kinase Pathway

(2013) Muhammad Arshad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans

(2013) Biljana Georgievska et al.   JOURNAL OF NEUROCHEMISTRY

Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

(2013) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

Inter-regulation of the unfolded protein response and auxin signaling

(2013) Yani Chen et al.   PLANT JOURNAL

FLZ Alleviates the Memory Deficits in Transgenic Mouse Model of Alzheimer’s Disease via Decreasing Beta-Amyloid Production and Tau Hyperphosphorylation

(2013) Xiu-Qi Bao et al.   PLoS One

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The unfolded protein response in Alzheimer’s disease

(2013) Víctor Hugo Cornejo et al.   Seminars in Immunopathology

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease

(2013) Lauren D Stutzbach et al.   Acta Neuropathologica Communications

The Role of ER Stress-Induced Apoptosis in Neurodegeneration

(2012) Ioanna C. Stefani et al.   Current Alzheimer Research

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

CHOP is a multifunctional transcription factor in the ER stress response

(2012) H. Nishitoh   JOURNAL OF BIOCHEMISTRY

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-  Precursor Protein

(2012) C. Parr et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondria-associated ER membranes in Alzheimer disease

(2012) Eric A. Schon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory

(2012) Daniela Puzzo et al.   NEUROBIOLOGY OF AGING

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

(2012) Sung Ok Yoon et al.   NEURON

Increased Tau Phosphorylation and Impaired Presynaptic Function in Hypertriglyceridemic ApoB-100 Transgenic Mice

(2012) Nikolett Lénárt et al.   PLoS One

mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1–JNK pathway

(2011) H Kato et al.   CELL DEATH AND DIFFERENTIATION

Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells

(2011) Gordon P. Meares et al.   EXPERIMENTAL CELL RESEARCH

c-Jun N-terminal Kinase Regulates Soluble Aβ Oligomers and Cognitive Impairment in AD Mouse Model

(2011) Alessandra Sclip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders

(2011) Karen M. Doyle et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Loss of c-Jun N-Terminal Protein Kinase Activity Prevents the Amyloidogenic Cleavage of Amyloid Precursor Protein and the Formation of Amyloid Plaques In Vivo

(2011) S. Mazzitelli et al.   JOURNAL OF NEUROSCIENCE

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

(2011) Diana AT Nijholt et al.   JOURNAL OF PATHOLOGY

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

(2011) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Morin attenuates tau hyperphosphorylation by inhibiting GSK3β

(2011) Eun Ji Gong et al.   NEUROBIOLOGY OF DISEASE

A Persistent Stress Response to Impeded Axonal Transport Leads to Accumulation of Amyloid-ß in the Endoplasmic Reticulum, and Is a Probable Cause of Sporadic Alzheimer’s Disease

(2011) Virgil Muresan et al.   Neurodegenerative Diseases

Overexpression of GRP78 protects glial cells from endoplasmic reticulum stress

(2011) Kaori Suyama et al.   NEUROSCIENCE LETTERS

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Disruption of neuronal function by soluble hyperphosphorylated tau in aDrosophilamodel of tauopathy

(2010) Catherine M. Cowan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Membrane rafts in Alzheimer's disease beta-amyloid production

(2010) Kulandaivelu S. Vetrivel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

(2010) Jin Hwan Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Spectroscopic Studies of GSK3β Phosphorylation of the Neuronal Tau Protein and Its Interaction with the N-terminal Domain of Apolipoprotein E

(2010) Arnaud Leroy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease

(2010) Steven P. Braithwaite et al.   NEUROBIOLOGY OF DISEASE

Hyperglycemia-induced endoplasmic reticulum stress in endothelial cells

(2010) Mae Sheikh-Ali et al.   NUTRITION

Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress

(2010) Do Yeon Lee et al.   PLoS One

The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo

(2010) Carin A. Loewen et al.   PLoS One

Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity

(2010) S. W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER and aging—Protein folding and the ER stress response

(2009) Nirinjini Naidoo   AGEING RESEARCH REVIEWS

Biphasic, Bidirectional Regulation of NF-κB by Endoplasmic Reticulum Stress

(2009) Masanori Kitamura   ANTIOXIDANTS & REDOX SIGNALING

Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway

(2009) Keita Takahashi et al.   JOURNAL OF NEUROCHEMISTRY

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

(2009) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

(2009) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

Alzheimer’s Disease Amyloid β-Protein and Synaptic Function

(2009) Tomas Ondrejcak et al.   NEUROMOLECULAR MEDICINE

Nicotine Suppresses Tunicamycin-Induced, But Not Thapsigargin-Induced, Expression of GRP78 during ER Stress-Mediated Apoptosis in PC12 Cells

(2008) H. Sasaya et al.   JOURNAL OF BIOCHEMISTRY

Endoplasmic Reticulum (ER) Chaperone Regulation and Survival of Cells Compensating for Deficiency in the ER Stress Response Kinase, PERK

(2008) Yukihiro Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON