Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders

Cocaine-mediated microglial activation involves the ER stress-autophagy axis

(2015) Ming-Lei Guo et al.   Autophagy

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

Autophagy receptor defects and ALS-FTLD

(2015) Veronika Majcher et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Role of Sigma Receptor in Cocaine-Mediated Induction of Glial Fibrillary Acidic Protein: Implications for HAND

(2015) Lu Yang et al.   MOLECULAR NEUROBIOLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond

(2015) Amma F. Agyemang et al.   Seminars in Immunopathology

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Decreased neuronal autophagy in HIV dementia: A mechanism of indirect neurotoxicity

(2014) Mehrdad Alirezaei et al.   Autophagy

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

(2014) Douglas R. Green et al.   CELL

Diacylglycerol Kinase α Regulates Tubular Recycling Endosome Biogenesis and Major Histocompatibility Complex Class I Recycling

(2014) Shuwei Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Degradation of the Complement Regulator, CD59, by a Novel Inhibitor

(2014) Bishuang Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Death-Associated Protein Kinase 1 Expression and Autophagy via ATF6 Requires Apoptosis Signal-Regulating Kinase 1

(2014) P. Gade et al.   MOLECULAR AND CELLULAR BIOLOGY

HIV Tat-Mediated Induction of Human Brain Microvascular Endothelial Cell Apoptosis Involves Endoplasmic Reticulum Stress and Mitochondrial Dysfunction

(2014) Rong Ma et al.   MOLECULAR NEUROBIOLOGY

Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons

(2014) Hyun-Hee Ryu et al.   NEUROBIOLOGY OF AGING

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease

(2014) Teng Jiang et al.   PHARMACOLOGICAL RESEARCH

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress

(2014) J M van der Harg et al.   Cell Death & Disease

Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease

(2013) Elena Alberdi et al.   AGING CELL

XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells

(2013) Ying Zhao et al.   CELL RESEARCH

Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production

(2013) Marc Suárez-Calvet et al.   JOURNAL OF NEUROCHEMISTRY

Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

(2013) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer

(2013) Jerel Fields et al.   JOURNAL OF NEUROVIROLOGY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Beta amyloid peptide plaques fail to alter evoked neuronal calcium signals in APP/PS1 Alzheimer's disease mice

(2013) Clark A. Briggs et al.   NEUROBIOLOGY OF AGING

Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation

(2013) Diana A.T. Nijholt et al.   NEUROBIOLOGY OF AGING

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance

(2013) Irina Lonskaya et al.   PLoS One

ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation

(2013) Adam K. Walker et al.   PLoS One

Presenilin-ryanodine receptor connection

(2013) L. D'Adamio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents

(2013) Y. E. Karapetyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

The Role of Autophagy in Parkinson's Disease

(2013) M. A. Lynch-Day et al.   Cold Spring Harbor Perspectives in Medicine

Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response

(2013) Petra Haberzettl et al.   Redox Biology

The genetics and neuropathology of frontotemporal lobar degeneration

(2012) Anne Sieben et al.   ACTA NEUROPATHOLOGICA

Role of Endolysosomes in HIV-1 Tat-Induced Neurotoxicity

(2012) Liang Hui et al.   ASN Neuro

IFNG and autophagy

(2012) Dhananjaya V. Kalvakolanu et al.   Autophagy

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling

(2012) Patricia Gómez-Suaga et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions

(2012) Javier Simón-Sánchez et al.   BRAIN

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress

(2012) Shane Deegan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Optineurin and amyotrophic lateral sclerosis

(2012) Hirofumi Maruyama et al.   Geriatrics & Gerontology International

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

(2012) Rene L. Vidal et al.   HUMAN MOLECULAR GENETICS

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

(2012) Andrea Longatti et al.   JOURNAL OF CELL BIOLOGY

Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease

(2012) C. J. Cortes et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome

(2012) David A. Tumbarello et al.   NATURE CELL BIOLOGY

Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase

(2012) Manal A. Farg et al.   NEUROBIOLOGY OF AGING

Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROBIOLOGY OF AGING

Activation of the Unfolded Protein Response Is an Early Event in Alzheimer’s and Parkinson’s Disease

(2012) Jeroen J.M. Hoozemans et al.   Neurodegenerative Diseases

Protein Disulfide Isomerase Regulates Endoplasmic Reticulum Stress and the Apoptotic Process during Prion Infection and PrP Mutant-Induced Cytotoxicity

(2012) Shao-Bin Wang et al.   PLoS One

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

(2012) Y. Kawahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

(2012) Yoichi Imaizumi et al.   Molecular Brain

Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders

(2011) Tibor Hortobágyi et al.   ACTA NEUROPATHOLOGICA

Reticulon 3 attenuates the clearance of cytosolic prion aggregates via inhibiting autophagy

(2011) Rui Chen et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease

(2011) D A T Nijholt et al.   CELL DEATH AND DIFFERENTIATION

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2011) Hui-Ming Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Regulation of Autophagy by Neuropathological Protein TDP-43

(2011) Jayarama Krishnan Bose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Is Increased in Postmortem Brains of Persons With HIV-1-Associated Encephalitis

(2011) Dejiang Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

(2011) Diana AT Nijholt et al.   JOURNAL OF PATHOLOGY

IRE1-Dependent Activation of AMPK in Response to Nitric Oxide

(2011) G. P. Meares et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

(2011) Han-Xiang Deng et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

Activation status of integrated stress response pathways in neurones and astrocytes of HIV-associated neurocognitive disorders (HAND) cortex

(2011) C. Akay et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction

(2010) James CB Li et al.   AIDS

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Negative regulation of autophagy

(2010) C Liang   CELL DEATH AND DIFFERENTIATION

Luminal Domain of ATF6 Alone Is Sufficient for Sensing Endoplasmic Reticulum Stress and Subsequent Transport to the Golgi Apparatus

(2010) Yoshimi Sato et al.   CELL STRUCTURE AND FUNCTION

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

(2010) Dorothee Dormann et al.   EMBO JOURNAL

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Endoplasmic Reticulum Stress in Motor Neurons of the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis

(2010) Shoichi Sasaki   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis

(2010) S. J. Barmada et al.   JOURNAL OF NEUROSCIENCE

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases

(2010) Stephen J DeArmond et al.   Molecular Neurodegeneration

Endoplasmic reticulum stress and atherosclerosis

(2010) Gökhan S Hotamisligil   NATURE MEDICINE

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Regulation of autophagy by ATF4 in response to severe hypoxia

(2010) T Rzymski et al.   ONCOGENE

HIV-1 Inhibits Autophagy in Bystander Macrophage/Monocytic Cells through Src-Akt and STAT3

(2010) Jennifer Van Grol et al.   PLoS One

Transcriptional Analysis Implicates Endoplasmic Reticulum Stress in Bovine Spongiform Encephalopathy

(2010) Yue Tang et al.   PLoS One

Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress

(2010) Mauricio Torres et al.   PLoS One

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

(2010) S.-C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

VCPMutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death

(2009) Michael A. Gitcho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

(2009) Andreas Heiseke et al.   JOURNAL OF NEUROCHEMISTRY

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The autophagy effector Beclin 1: a novel BH3-only protein

(2009) S Sinha et al.   ONCOGENE

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effect against Parkinson's disease-related insults through the activation of XBP1

(2008) Megumi Sado et al.   BRAIN RESEARCH

The Stress Rheostat: An Interplay Between the Unfolded Protein Response (UPR) and Autophagy in Neurodegeneration

(2008) Soledad Matus et al.   CURRENT MOLECULAR MEDICINE

Acute headache: a prospective diagnostic work-up of patients admitted to a general hospital - CME questions

(2008) S. H. Bø et al.   EUROPEAN JOURNAL OF NEUROLOGY

Structural determinants of the cellular localization and shuttling of TDP-43

(2008) Y. M. Ayala et al.   JOURNAL OF CELL SCIENCE

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

(2008) Vivianna M Van Deerlin et al.   LANCET NEUROLOGY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE

Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration

(2008) Mehrdad Alirezaei et al.   PLoS One

HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization

(2008) John P. Norman et al.   PLoS One

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis

(2008) C. Hetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity

(2007) Mark R. Wilson et al.   Molecular BioSystems