AID Biology: A pathological and clinical perspective

A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger’s CATalytic Pocket

(2017) Justin J. King et al.   Frontiers in Immunology

Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins

(2016) Samiran Mondal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous Carcinogenesis

(2016) Stav Sapoznik et al.   NEOPLASIA

Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations

(2015) Y. Sawai et al.   CANCER RESEARCH

Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma

(2015) Davide F. Robbiani et al.   CELL

Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA

(2015) Simin Zheng et al.   CELL

Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy

(2015) Kiyoko Kawamura et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Catalytic Pocket Inaccessibility of Activation-Induced Cytidine Deaminase Is a Safeguard against Excessive Mutagenic Activity

(2015) Justin J. King et al.   STRUCTURE

B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity

(2014) Jason Qian et al.   CELL

Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability

(2014) Fei-Long Meng et al.   CELL

Comment on "Activation-Induced Cytidine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis and MALT Lymphoma in Sjogren's Syndrome"

(2014) O. Thaunat et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: A cis-Acting DNA Element Targets AID-Mediated Sequence Diversification to the Chicken Ig Light Chain Gene Locus

(2014) N. Kothapalli et al.   JOURNAL OF IMMUNOLOGY

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

(2014) Richard L Frock et al.   NATURE BIOTECHNOLOGY

Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination

(2014) A. Zahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Of Somatic Hypermutation By immunoglobulin Enhancer And Enhancer-Like Sequences

(2014) Jean-Marie Buerstedde et al.   PLOS BIOLOGY

Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID

(2013) Prashant Kodgire et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Critical Context-Dependent Role for E Boxes in the Targeting of Somatic Hypermutation

(2013) J. J. McDonald et al.   JOURNAL OF IMMUNOLOGY

Multiple Transcription Factor Binding Sites Predict AID Targeting in Non-Ig Genes

(2013) J. L. Duke et al.   JOURNAL OF IMMUNOLOGY

Role of Activation-Induced Cytidine Deaminase in the Development of Oral Squamous Cell Carcinoma

(2013) Yosuke Nakanishi et al.   PLoS One

Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase

(2013) C. S. Nabel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Host Activation-Induced Cytidine Deaminase in Innate Immune Defense against KSHV

(2013) Elena Bekerman et al.   PLoS Pathogens

Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine Deaminase

(2012) Davide F. Robbiani et al.   Annual Review of Pathology-Mechanisms of Disease

Critical role of activation induced cytidine deaminase in Experimental Autoimmune Encephalomyelitis

(2012) Yonglian Sun et al.   AUTOIMMUNITY

Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans

(2012) Anne Durandy et al.   AUTOIMMUNITY

Nucleosome Stability Dramatically Impacts the Targeting of Somatic Hypermutation

(2012) P. Kodgire et al.   MOLECULAR AND CELLULAR BIOLOGY

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation

(2012) Christopher S Nabel et al.   Nature Chemical Biology

Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1

(2012) Y. Kanehiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

(2012) J. G. Lohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Expression and Mutation-Inducing Activity of AID in Human Lung Cancer

(2011) Kazuya Shinmura et al.   ANNALS OF SURGICAL ONCOLOGY

AID dysregulation in lupus-prone MRL/Faslpr/lprmice increases class switch DNA recombination and promotes interchromosomalc-Myc/IgHloci translocations: Modulation by HoxC4

(2011) Clayton A. White et al.   AUTOIMMUNITY

Repression of human activation induced cytidine deaminase by miR-93 and miR-155

(2011) Glen M Borchert et al.   BMC CANCER

Role of activation-induced cytidine deaminase in the progression of follicular lymphoma

(2011) Hisaharu Shikata et al.   CANCER SCIENCE

Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

(2011) Isaac A. Klein et al.   CELL

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

(2011) Uttiya Basu et al.   CELL

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination

(2011) Beena Patricia Jeevan-Raj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1  (eEF1A)

(2011) J. Hasler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination

(2011) L. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation-Induced Cytidine Deaminase Accelerates Clonal Evolution in BCR-ABL1-Driven B-Cell Lineage Acute Lymphoblastic Leukemia

(2010) T. A. Gruber et al.   CANCER RESEARCH

Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5

(2010) Rushad Pavri et al.   CELL

GANP-mediated Recruitment of Activation-induced Cytidine Deaminase to Cell Nuclei and to Immunoglobulin Variable Region DNA

(2010) Kazuhiko Maeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Attracting AID to targets of somatic hypermutation

(2010) Atsushi Tanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90

(2010) Alexandre Orthwein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancers

(2010) Yoko Endo et al.   JOURNAL OF GASTROENTEROLOGY

The recruitment of activation induced cytidine deaminase to the immunoglobulin locus by a regulatory element

(2010) Yonghwan Kim et al.   MOLECULAR IMMUNOLOGY

The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA

(2010) Urszula Nowak et al.   NATURE IMMUNOLOGY

Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions

(2010) Robert W Maul et al.   NATURE IMMUNOLOGY

14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′–rich switch regions for class switch recombination

(2010) Zhenming Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The B Cell Mutator AID Promotes B Lymphoid Blast Crisis and Drug Resistance in Chronic Myeloid Leukemia

(2009) Lars Klemm et al.   CANCER CELL

Cytogenetics and Molecular Genetics of Acute Lymphoblastic Leukemia

(2009) Krzysztof Mrózek et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

DNA-dependent Protein Kinase-mediated Phosphorylation of Protein Kinase B Requires a Specific Recognition Sequence in the C-terminal Hydrophobic Motif

(2009) Jongsun Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase

(2009) Rahul M. Kohli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability

(2009) Dominik Schenten et al.   JOURNAL OF EXPERIMENTAL MEDICINE

S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination

(2009) Lili Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Estrogen directly activates AID transcription and function

(2009) Siim Pauklin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Critical Role for REV1 in Regulating the Induction of C:G Transitions and A:T Mutations during Ig Gene Hypermutation

(2009) K. Masuda et al.   JOURNAL OF IMMUNOLOGY

Different isoforms of the B-cell mutator activation-induced cytidine deaminase are aberrantly expressed in BCR–ABL1-positive acute lymphoblastic leukemia patients

(2009) I Iacobucci et al.   LEUKEMIA

AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations

(2009) Davide F. Robbiani et al.   MOLECULAR CELL

Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination

(2009) Bao Q Vuong et al.   NATURE IMMUNOLOGY

Increased Expression of Activation-Induced Cytidine Deaminase is Associated with Anti-CCP and Rheumatoid Factor in Rheumatoid Arthritis

(2009) X. Xu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

A cis-Acting Diversification Activator Both Necessary and Sufficient for AID-Mediated Hypermutation

(2009) Artem Blagodatski et al.   PLoS Genetics

Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cells

(2008) X. Wu et al.   BLOOD

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations

(2008) Davide F. Robbiani et al.   CELL

Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers

(2008) Yoko Endo et al.   GASTROENTEROLOGY

Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40

(2008) Waka Lin et al.   GENES TO CELLS

Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma

(2008) Junji Komori et al.   HEPATOLOGY

Regulation of class switch recombination and somatic mutation by AID phosphorylation

(2008) Kevin M. McBride et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteasomal degradation restricts the nuclear lifespan of AID

(2008) Said Aoufouchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Primary Cutaneous Marginal Zone B-Cell Lymphomas Are Targeted by Aberrant Somatic Hypermutation

(2008) Alexander J.A. Deutsch et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations

(2008) A Takai et al.   ONCOGENE

Post-translational regulation of activation-induced cytidine deaminase

(2008) U. Basu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA

(2007) Sukhdev S. Brar et al.   DNA REPAIR