Article
Biochemistry & Molecular Biology
Asami Nishikori, Yoshito Nishimura, Rei Shibata, Koh-ichi Ohshima, Yuka Gion, Tomoka Ikeda, Midori Filiz Nishimura, Tadashi Yoshino, Yasuharu Sato
Summary: AID expression in IgG4-related diseases is influenced by various factors, and AID may play a key role in driving fibrosis and oncogenesis in ocular adnexal organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Takashi Iizuka, Kousho Wakae, Masanori Ono, Takuma Suzuki, Yasunari Mizumoto, Kouichi Kitamura, Shin-ichi Horike, Masamichi Muramatsu, Hiroshi Fujiwara
Summary: The study revealed that AID plays a significant role in regulating the expression of GDF-9 and SCF in the ovary, possibly through a GDF-9 and SCF feedback system to modulate communication between oocytes and granulosa cells.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Qian Jia, Hui Zeng, Huanxi Li, Nan Xiao, Jing Tang, Shangfang Gao, Jinbing Zhang, Wei Xie
Summary: In this study, the researchers determined the structures of GSDA in plants, revealing its catalytic mechanism and structural rearrangements during reactions. The identification of additional substrates and comparison with other deaminases helped uncover recognition differences for specific substrates. These findings may contribute to the development of deaminase-based gene-editing tools.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Junna Jiao, Zhuang Qian, Yurong Wang, Mei Liu, Liye Fan, Mengqing Liu, Zichen Hao, Junrong Jiao, Zhuangwei Lv
Summary: Sonodynamic therapy using MWO4-PEG NPs shows promising inhibitory effects on activation-induced cytidine deaminase (AID) in diffuse large B-cell lymphoma. The interaction between reactive oxygen species and AID was investigated, and the NPs were found to effectively neutralize the extensive carcinogenesis caused by AID. Cell apoptosis and ROS generation in DLBCL cells treated with these NPs were observed to confirm their sonosensitivity and toxicity, indicating their potential as a treatment for AID-positive hematopoietic cancers.
Article
Hematology
W. Richard Burack, Hongli Li, Diana Adlowitz, Janice M. Spence, Lisa M. Rimsza, Mazyar Shadman, Catherine M. Spier, Mark S. Kaminski, John P. Leonard, Michael L. Leblanc, Sonali M. Smith, Jonathan W. Friedberg
Summary: Subclonal TP53 mutations are common in follicular lymphoma and are distinct from AICDA-mediated genetic heterogeneity. Patients with no detectable subclonal mutation in TP53 benefit particularly from RIT.
Article
Oncology
Cristina Correia, Matthew J. J. Maurer, Samantha J. J. McDonough, Paula A. A. Schneider, Paige E. E. Ross, Anne J. J. Novak, Andrew L. L. Feldman, James R. R. Cerhan, Susan L. L. Slager, Thomas E. E. Witzig, Bruce W. W. Eckloff, Hu Li, Grzegorz S. S. Nowakowski, Scott H. H. Kaufmann
Summary: The identification of follicular lymphoma (FL) patients with low disease burden but high risk for early progression is unclear. In a study on newly diagnosed FLs, BCL2 mutations with high variant allele frequency (VAF) were found to be associated with increased transformation risk and shorter event-free survival. However, other sequenced genes did not contribute significantly to the prognostic value of the panel. Nonsynonymous BCL2 mutations with VAF = 20% were consistently associated with decreased event-free survival and overall survival.
BLOOD CANCER JOURNAL
(2023)
Article
Oncology
Grant Godsmark, Leonardo Alves De Souza Rios, Shaheen Mowla
Summary: The study demonstrated that AID is highly specific to B-cell-derived cancers, with ectopic overexpression leading to rapid cell death, and silencing AID significantly impacting genomic stability, proliferation, migration, and drug resistance. AID is identified as an important driver of lymphoma, affecting multiple cellular events, and potentially a strong candidate for targeted therapy in lymphoma.
ANTICANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xia Xie, Tingting Gan, Bing Rao, Weiwei Zhang, Rohit A. Panchakshari, Dingpeng Yang, Xiong Ji, Yu Cao, Frederick W. Alt, Fei-Long Meng, Jiazhi Hu
Summary: The mutant AID-delC protein fails to efficiently target antibody genes, forms condensates, and may exert a dominant-negative effect on wild-type AID.
Review
Genetics & Heredity
Tony M. Mertz, Christopher D. Collins, Madeline Dennis, Margo Coxon, Steven A. Roberts
Summary: The occurrence and development of cancer are closely related to mutations, and dysregulated activity of APOBECs can lead to mutations. The study of mutation signatures helps us understand the patterns and processes of mutations. In humans, APOBEC-generated genetic heterogeneity plays an important role in cancer development, metastasis, and resistance to therapy.
ANNUAL REVIEW OF GENETICS
(2022)
Article
Medicine, General & Internal
Shohei Kikuchi, Akinori Wada, Yusuke Kamihara, Yoshimi Nabe, Tomoki Minemura, Jun Murakami, Nam H. H. Dang, Tsutomu Sato
Summary: Biclonal gammopathy is a rare phenomenon characterized by the detection of 2 M proteins in the same patient. The etiology of this condition remains unclear. In this study, we found double positive cells in two cases of B-cell malignancy with biclonal gammopathy, suggesting a possible involvement of cell transition and class switch recombination. Immunostaining revealed the expression of activation induced cytidine deaminase in these cells, indicating its potential role in the pathogenesis of biclonal gammopathy.
Article
Biotechnology & Applied Microbiology
Baole Qu, Yun Zhao, Lili An, Haiying Hang
Summary: This study demonstrates that adenine deaminase (ADA) can efficiently induce random A/T to G/C mutations on the target gene in CHO cell display, and can be applied in affinity maturation to improve antibody affinity. The combined use of ADA and activation-induced cytidine deaminase (AID) provides more mutant types, offering an opportunity to acquire new mutants with higher affinities than those obtained by only using AID.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Immunology
Junna Jiao, Zhuangwei Lv, Yurong Wang, Liye Fan, Angang Yang
Summary: Activation-induced cytidine deaminase (AID) plays a crucial role in promoting B cell diversification through somatic hypermutation (SHM) and class switch recombination (CSR). Apart from its physiological function of humoral immune response, AID has been linked to the initiation and progression of lymphomas. This review proposes an alternative role for AID and explores its off-target effects in regulating tumorigenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Zhiwei Hu, Yannan Wang, Qian Liu, Yan Qiu, Zhiyu Zhong, Kangdi Li, Wenhua Li, Zixin Deng, Yuhui Sun
Summary: This study introduces a novel approach using bubble hairpin single guide RNAs (BH-sgRNAs) to significantly reduce off-target editing and improve the purity of on-target editing in base editors. This design represents a major improvement in the specificity of base editing tools.
Article
Microbiology
Feixuan Li, Xiao-Yu Liu, Lei Ni, Fan Jin
Summary: Researchers developed a method called AIDmut-Seq to detect transcription factor targets on the genome. It involves simple steps and has been validated for various transcriptional activators. However, it has lower efficiency for some small transcriptional repressors. Despite potential false-positive and false-negative results, AIDmut-Seq shows promise as a complementary tool for studying protein-DNA interactions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Oncology
Maria Schubert, Franz Josef Gassner, Michael Huemer, Jan Philip Hoepner, Ekaterina Akimova, Markus Steiner, Alexander Egle, Richard Greil, Nadja Zaborsky, Roland Geisberger
Summary: The study demonstrates that AID contributes to the acquisition of somatic cancer-specific mutations in chronic lymphocytic leukemia, leading to accelerated disease progression and affecting the survival rate of mice. Therefore, further research on the impact of AID inhibition on drug resistance development is crucial.
