Mesenchymal stem cells maintain the microenvironment of central nervous system by regulating the polarization of macrophages/microglia after traumatic brain injury

Very Early Administration of Progesterone Does Not Improve Neuropsychological Outcomes in Subjects with Moderate to Severe Traumatic Brain Injury

(2017) Felicia C. Goldstein et al.   JOURNAL OF NEUROTRAUMA

The far-reaching scope of neuroinflammation after traumatic brain injury

(2017) Dennis W. Simon et al.   Nature Reviews Neurology

Biomechanical Forces Promote Immune Regulatory Function of Bone Marrow Mesenchymal Stromal Cells

(2017) Miguel F. Diaz et al.   STEM CELLS

Priming Equine Bone Marrow-Derived Mesenchymal Stem Cells with Proinflammatory Cytokines: Implications in Immunomodulation–Immunogenicity Balance, Cell Viability, and Differentiation Potential

(2017) Laura Barrachina et al.   STEM CELLS AND DEVELOPMENT

Signal Factors Secreted by 2D and Spheroid Mesenchymal Stem Cells and by Cocultures of Mesenchymal Stem Cells Derived Microvesicles and Retinal Photoreceptor Neurons

(2017) Lili Xie et al.   Stem Cells International

Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder

(2016) Hyun Jung Park et al.   ACTA NEUROPATHOLOGICA

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

Wormhole Travel for Macrophages

(2016) Yasutaka Okabe et al.   CELL

Mesenchymal stem cells promote macrophage polarization toward M2b-like cells

(2016) Gyöngyi Kudlik et al.   EXPERIMENTAL CELL RESEARCH

3D spheroid culture enhances survival and therapeutic capacities of MSCs injected into ischemic kidney

(2016) Yong Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reassembly of Excitable Domains after CNS Axon Regeneration

(2016) M. A. Marin et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in animal models of traumatic brain injury

(2016) Chong-Chi Chiu et al.   JOURNAL OF NEUROSCIENCE METHODS

Policy: Global standards for stem-cell research

(2016) Jonathan Kimmelman et al.   NATURE

The role of autophagy in modulation of neuroinflammation in microglia

(2016) P. Su et al.   NEUROSCIENCE

Z-guggulsterone negatively controls microglia-mediated neuroinflammation via blocking IκB-α–NF-κB signals

(2016) Chao Huang et al.   NEUROSCIENCE LETTERS

Wnt3a, a Protein Secreted by Mesenchymal Stem Cells Is Neuroprotective and Promotes Neurocognitive Recovery Following Traumatic Brain Injury

(2016) Yuhai Zhao et al.   STEM CELLS

Human Mesenchymal Stem Cell-Derived Microvesicles Prevent the Rupture of Intracranial Aneurysm in Part by Suppression of Mast Cell Activation via a PGE2-Dependent Mechanism

(2016) Jia Liu et al.   STEM CELLS

Clinical Outcomes of Transplanted Modified Bone Marrow–Derived Mesenchymal Stem Cells in Stroke

(2016) Gary K. Steinberg et al.   STROKE

Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte

(2016) Yan Gu et al.   Scientific Reports

Role of VEGF-A in angiogenesis promoted by umbilical cord-derived mesenchymal stromal/stem cells: in vitro study

(2016) Irina Arutyunyan et al.   Stem Cell Research & Therapy

Human mesenchymal stromal/stem cells acquire immunostimulatory capacity upon cross-talk with natural killer cells and might improve the NK cell function of immunocompromised patients

(2016) Rongtao Cui et al.   Stem Cell Research & Therapy

Mesenchymal Stem Cells Modulate the Functional Properties of Microglia via TGF-β Secretion

(2016) Min Young Noh et al.   Stem Cells Translational Medicine

Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection

(2015) Xiang Zeng et al.   BIOMATERIALS

Identification of IL-1β and LPS as optimal activators of monolayer and alginate-encapsulated mesenchymal stromal cell immunomodulation using design of experiments and statistical methods

(2015) Andrea Gray et al.   BIOTECHNOLOGY PROGRESS

Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

(2015) Naomi D’souza et al.   BMC Medicine

How microglia kill neurons

(2015) Guy C. Brown et al.   BRAIN RESEARCH

Cell-Based therapy for traumatic brain injury

(2015) S. Gennai et al.   BRITISH JOURNAL OF ANAESTHESIA

Multipotent bone marrow stromal cell therapy promotes endogenous cell proliferation following ischemic stroke

(2015) Gila Pirzad Jahromi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Alginate micro-encapsulation of mesenchymal stromal cells enhances modulation of the neuro-inflammatory response

(2015) Elizabeth C. Stucky et al.   CYTOTHERAPY

Endogenous prostaglandin E2 potentiates anti-inflammatory phenotype of macrophage through the CREB-C/EBP-β cascade

(2015) Yi Rang Na et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Paracrine Factors Secreted by MSCs Promote Astrocyte Survival Associated With GFAP Downregulation After Ischemic Stroke via p38 MAPK and JNK

(2015) Weiyi Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The inhibitory effect of mesenchymal stem cell on blood–brain barrier disruption following intracerebral hemorrhage in rats: contribution of TSG-6

(2015) Min Chen et al.   Journal of Neuroinflammation

Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

(2015) Kyria M. Webster et al.   Journal of Neuroinflammation

Co-Graft of Bone Marrow Stromal Cells and Schwann Cells Into Acellular Nerve Scaffold for Sciatic Nerve Regeneration in Rats

(2015) Li-Na Zhou et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

A functional progesterone receptor is required for immunomodulation, reduction of reactive gliosis and survival of oligodendrocyte precursors in the injured spinal cord

(2015) Florencia Labombarda et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study

(2015) Marlies E. J. Reinders et al.   Journal of Translational Medicine

Clinical evidence of inflammation driving secondary brain injury

(2015) Holly E. Hinson et al.   Journal of Trauma and Acute Care Surgery

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity

(2015) Mika Yasui et al.   PLoS One

Survival and Biodistribution of Xenogenic Adipose Mesenchymal Stem Cells Is Not Affected by the Degree of Inflammation in Arthritis

(2015) Karine Toupet et al.   PLoS One

Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female mice

(2015) Ana Belen Lopez-Rodriguez et al.   PSYCHONEUROENDOCRINOLOGY

Engineered Mesenchymal Stem Cells with Enhanced Tropism and Paracrine Secretion of Cytokines and Growth Factors to Treat Traumatic Brain Injury

(2015) Zhe Wang et al.   STEM CELLS

PI3kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization

(2015) Marwan Mounayar et al.   STEM CELLS

Pre-activation of mesenchymal stem cells with TNF-α, IL-1β and nitric oxide enhances its paracrine effects on radiation-induced intestinal injury

(2015) Hao Chen et al.   Scientific Reports

Altered protein secretions during interactions between adipose tissue- or bone marrow-derived stromal cells and inflammatory cells

(2015) Hidemi Hattori et al.   Stem Cell Research & Therapy

Intracarotid Infusion of Mesenchymal Stem Cells in an Animal Model of Parkinson's Disease, Focusing on Cell Distribution and Neuroprotective and Behavioral Effects

(2015) Silvia Cerri et al.   Stem Cells Translational Medicine

Propranolol and Mesenchymal Stromal Cells Combine to Treat Traumatic Brain Injury

(2015) Daniel J. Kota et al.   Stem Cells Translational Medicine

Clinical evidence of inflammation driving secondary brain injury

(2015) Holly E. Hinson et al.   Journal of Trauma and Acute Care Surgery

Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage Polarization

(2015) Guoping Zheng et al.   Stem Cells International

The Many Alternative Faces of Macrophage Activation

(2015) David A. Hume   Frontiers in Immunology

Fractional factorial design to investigate stromal cell regulation of macrophage plasticity

(2014) Jeffrey A. Barminko et al.   BIOTECHNOLOGY AND BIOENGINEERING

Serum from patients with systemic vasculitis induces alternatively activated macrophage M2c polarization

(2014) Susanne M. Ohlsson et al.   CLINICAL IMMUNOLOGY

Nanomedicine and its Application in Treatment of Microglia-mediated Neuroinflammation

(2014) N. Baby et al.   CURRENT MEDICINAL CHEMISTRY

Inflammation and Immune System Activation After Traumatic Brain Injury

(2014) Ramani Balu   Current Neurology and Neuroscience Reports

Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury

(2014) Vanessa Donega et al.   EXPERIMENTAL NEUROLOGY

Redox regulation of NF-κB p50 and M1 polarization in microglia

(2014) Thomas Taetzsch et al.   GLIA

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4

(2014) Giovanna Pepe et al.   Journal of Neuroinflammation

Macrophagic and microglial responses after focal traumatic brain injury in the female rat

(2014) L Turtzo et al.   Journal of Neuroinflammation

Mesenchymal stem cells inhibit lipopolysaccharide-induced inflammatory responses of BV2 microglial cells through TSG-6

(2014) Yi Liu et al.   Journal of Neuroinflammation

Reparative Therapy for Acute Ischemic Stroke with Allogeneic Mesenchymal Stem Cells from Adipose Tissue: A Safety Assessment

(2014) Exuperio Díez-Tejedor et al.   Journal of Stroke & Cerebrovascular Diseases

Pheophytin a and chlorophyll a suppress neuroinflammatory responses in lipopolysaccharide and interferon-γ-stimulated BV2 microglia

(2014) Sunyoung Park et al.   LIFE SCIENCES

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Bone Marrow Mesenchymal Stromal Cells Drive Protective M2 Microglia Polarization After Brain Trauma

(2014) Elisa R. Zanier et al.   Neurotherapeutics

Human Chorionic Villous Mesenchymal Stem Cells Modify the Functions of Human Dendritic Cells, and Induce an Anti-Inflammatory Phenotype in CD1+ Dendritic Cells

(2014) F. M. Abomaray et al.   Stem Cell Reviews and Reports

Mesenchymal Stem Cells Maintain Blood-Brain Barrier Integrity by Inhibiting Aquaporin-4 Upregulation After Cerebral Ischemia

(2014) Guanghui Tang et al.   STEM CELLS

Regulation of Mouse Microglia Activation and Effector Functions by Bone Marrow-Derived Mesenchymal Stem Cells

(2014) Beáta Hegyi et al.   STEM CELLS AND DEVELOPMENT

Mesenchymal Stem Cell Paracrine Activity Is Modulated by Platelet Lysate: Induction of an Inflammatory Response and Secretion of Factors Maintaining Macrophages in a Proinflammatory Phenotype

(2014) Valentina Ulivi et al.   STEM CELLS AND DEVELOPMENT

Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: A randomized, placebo-controlled, multiple-dose study

(2014) Fred D. Lublin et al.   Multiple Sclerosis and Related Disorders

Uncovering the secretes of mesenchymal stem cells

(2013) Jessie R. Lavoie et al.   BIOCHIMIE

Treatment of Graft versus Host Disease with Mesenchymal Stromal Cells: A Phase I Study on 40 Adult and Pediatric Patients

(2013) Martino Introna et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity

(2013) Natalie L. Payne et al.   BRAIN BEHAVIOR AND IMMUNITY

A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and functionin vitroandin vivo

(2013) Christina E. Arnold et al.   IMMUNOLOGY

TSG-6 Released from Intradermally Injected Mesenchymal Stem Cells Accelerates Wound Healing and Reduces Tissue Fibrosis in Murine Full-Thickness Skin Wounds

(2013) Yu Qi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Commentary on Special Issue: CNS Diseases and the Immune System

(2013) Bert A. ‘t Hart et al.   Journal of Neuroimmune Pharmacology

Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury

(2013) Run Zhang et al.   Journal of Neuroinflammation

Immunomagnetic enrichment and flow cytometric characterization of mouse microglia

(2013) Supinder S. Bedi et al.   JOURNAL OF NEUROSCIENCE METHODS

Erythropoietin Improved Cognitive Function and Decreased Hippocampal Caspase Activity in Rat Pups after Traumatic Brain Injury

(2013) Michelle E. Schober et al.   JOURNAL OF NEUROTRAUMA

Changing patterns in the epidemiology of traumatic brain injury

(2013) Bob Roozenbeek et al.   Nature Reviews Neurology

Administration of TSG-6 improves memory after traumatic brain injury in mice

(2013) Jun Watanabe et al.   NEUROBIOLOGY OF DISEASE

Challenges for taking primary and stem cells into clinical neurotransplantation trials for neurodegenerative disease

(2013) Stephen B. Dunnett et al.   NEUROBIOLOGY OF DISEASE

Microglia: Multiple roles in surveillance, circuit shaping, and response to injury

(2013) E. E. Benarroch   NEUROLOGY

Adult Bone Marrow Neural Crest Stem Cells and Mesenchymal Stem Cells Are Not Able to Replace Lost Neurons in Acute MPTP-Lesioned Mice

(2013) Virginie Neirinckx et al.   PLoS One

In Vivo Fluorescence Imaging Reveals the Promotion of Mammary Tumorigenesis by Mesenchymal Stromal Cells

(2013) Chien-Chih Ke et al.   PLoS One

Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptors

(2013) M. Schumacher et al.   PROGRESS IN NEUROBIOLOGY

Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages

(2013) M. H. Abumaree et al.   Stem Cell Reviews and Reports

Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1)

(2013) Thomas J. Bartosh et al.   STEM CELLS

Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?

(2013) Matthew D. Griffin et al.   STEM CELLS

Concise Review: Two negative feedback loops place mesenchymal stem/stromal cells at the center of early regulators of inflammation

(2013) Darwin J. Prockop   STEM CELLS

The Role of Markers of Inflammation in Traumatic Brain Injury

(2013) Thomas Woodcock et al.   Frontiers in Neurology

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice

(2012) R. Parsa et al.   DIABETES

Autologous Bone Marrow Mesenchymal Stem Cell Therapy in the Subacute Stage of Traumatic Brain Injury by Lumbar Puncture

(2012) Chunlei Tian et al.   Experimental and Clinical Transplantation

Development and homeostasis of “resident” myeloid cells: The case of the microglia

(2012) Elisa Gomez Perdiguero et al.   GLIA

Macrophages modulate the viability and growth of human mesenchymal stem cells

(2012) Donald O. Freytes et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells

(2012) Boonrat Chantong et al.   Journal of Neuroinflammation

Combination of Temperature-Sensitive Stem Cells and Mild Hypothermia: A New Potential Therapy for Severe Traumatic Brain Injury

(2012) Yue Tu et al.   JOURNAL OF NEUROTRAUMA

Transplantation of Mesenchymal Stem Cells Promotes an Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury

(2012) Hideaki Nakajima et al.   JOURNAL OF NEUROTRAUMA

Attenuation of Microglial Activation with Minocycline Is Not Associated with Changes in Neurogenesis after Focal Traumatic Brain Injury in Adult Mice

(2012) Si Yun Ng et al.   JOURNAL OF NEUROTRAUMA

Hanging in the balance: endogenous anti-inflammatory mechanisms in tissue repair and fibrosis

(2012) Amiram Ariel et al.   JOURNAL OF PATHOLOGY

Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury

(2012) D. Meffre et al.   NEUROSCIENCE

Macrophage-Associated Mesenchymal Stem Cells Assume an Activated, Migratory, Pro-Inflammatory Phenotype with Increased IL-6 and CXCL10 Secretion

(2012) Kevin Anton et al.   PLoS One

Human Mesenchymal Stem/Stromal Cells Cultured as Spheroids are Self-activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti-inflammatory Phenotype

(2012) Joni H. YlÖstalo et al.   STEM CELLS

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF- B signaling in resident macrophages

(2011) H. Choi et al.   BLOOD

Epidemiology, Severity Classification, and Outcome of Moderate and Severe Traumatic Brain Injury: A Prospective Multicenter Study

(2011) Teuntje M.J.C. Andriessen et al.   JOURNAL OF NEUROTRAUMA

Long-Lasting Inhibitory Effects of Fetal Liver Mesenchymal Stem Cells on T-Lymphocyte Proliferation

(2011) Massimo Giuliani et al.   PLoS One

Bone Marrow Derived Mesenchymal Stem Cells Inhibit Inflammation and Preserve Vascular Endothelial Integrity in the Lungs after Hemorrhagic Shock

(2011) Shibani Pati et al.   PLoS One

Transplantation of magnetically labeled mesenchymal stem cells in a model of perinatal brain injury

(2010) Aiqing Chen et al.   Stem Cell Research

Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study

(2009) Rakhi Pal et al.   CYTOTHERAPY

Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation

(2009) Moonhee Lee et al.   GLIA

Combination Therapies for Traumatic Brain Injury: Prospective Considerations

(2009) Susan Margulies et al.   JOURNAL OF NEUROTRAUMA

Effect of Needle Diameter and Flow Rate on Rat and Human Mesenchymal Stromal Cell Characterization and Viability

(2009) Peter A. Walker et al.   TISSUE ENGINEERING PART C-METHODS

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY