Hanging in the balance: endogenous anti-inflammatory mechanisms in tissue repair and fibrosis

Adenosine in fibrosis

(2014) Edwin S. L. Chan et al.   Modern Rheumatology

A Novel, Dual Role of CCN3 in Experimental Glomerulonephritis

(2012) Claudia R.C. van Roeyen et al.   AMERICAN JOURNAL OF PATHOLOGY

BMP signaling in rats with TNBS-induced colitis following BMP7 therapy

(2012) Ivana Maric et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis

(2012) Gerhard Krönke et al.   ANNALS OF THE RHEUMATIC DISEASES

Protective effect of annexin-A1 against irreversible damage to cavernous tissue after cavernous nerve injury in the rat

(2012) Fernando N. Facio Jr et al.   BJU INTERNATIONAL

Novel Anti-Inflammatory-Pro-Resolving Mediators and Their Receptors

(2012) Charles N. Serhan et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction

(2012) Ye-Ji Lee et al.   EUROPEAN RESPIRATORY JOURNAL

The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation

(2012) Ester Pashover-Schallinger et al.   FASEB JOURNAL

Pharmacological blockade of adenosine A2A receptors diminishes scarring

(2012) Miguel Perez-Aso et al.   FASEB JOURNAL

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

(2012) Stefan Uderhardt et al.   IMMUNITY

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid

(2012) Yosuke Isobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteinase 3, the Autoantigen in Granulomatosis with Polyangiitis, Associates with Calreticulin on Apoptotic Neutrophils, Impairs Macrophage Phagocytosis, and Promotes Inflammation

(2012) J. Gabillet et al.   JOURNAL OF IMMUNOLOGY

Systemic Analysis of PPAR  in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity

(2012) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

NOV/CCN3 attenuates inflammatory pain through regulation of matrix metalloproteinases-2 and -9

(2012) Lara Kular et al.   Journal of Neuroinflammation

Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation

(2012) Xinli Qu et al.   JOURNAL OF PATHOLOGY

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

MFG-E8 Released by Apoptotic Endothelial Cells Triggers Anti-Inflammatory Macrophage Reprogramming

(2012) Marie-Joëlle Brissette et al.   PLoS One

Tregs Promote the Differentiation of Th17 Cells in Silica-Induced Lung Fibrosis in Mice

(2012) Laiyu Song et al.   PLoS One

Pathomechanisms of Myocardial Dysfunction in Sepsis

(2012) Clara Batista Lorigados et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Cellular and Molecular Mechanisms of Chronic Inflammation-Associated Organ Fibrosis

(2012) Satoshi Ueha et al.   Frontiers in Immunology

Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis

(2011) Xiangwei Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Platelet-Derived Growth Factor–Producing CD4+Foxp3+Regulatory T Lymphocytes Promote Lung Fibrosis

(2011) Sandra Lo Re et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hydrogen Sulfide: An Endogenous Mediator of Resolution of Inflammation and Injury

(2011) John L. Wallace et al.   ANTIOXIDANTS & REDOX SIGNALING

Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling

(2011) Xiaohua Yan et al.   BIOCHEMICAL JOURNAL

Transcriptomic analyses of murine resolution-phase macrophages

(2011) M. J. Stables et al.   BLOOD

Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis

(2011) Amílcar S Damazo et al.   BMC IMMUNOLOGY

LXRα Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8

(2011) Benoit Pourcet et al.   CIRCULATION RESEARCH

Biology of Transforming Growth Factor-β Signaling

(2011) Hiroaki Ikushima et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function

(2011) Reena Rani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lipoxin A4 and benzo-lipoxin A4 attenuate experimental renal fibrosis

(2011) Emma Börgeson et al.   FASEB JOURNAL

Lipoxin A4 is a novel estrogen receptor modulator

(2011) Ronan Russell et al.   FASEB JOURNAL

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

(2011) Balázs Csóka et al.   FASEB JOURNAL

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Heme Oxygenase-1 Couples Activation of Mitochondrial Biogenesis to Anti-inflammatory Cytokine Expression

(2011) Claude A. Piantadosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38/MKP-1–regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair

(2011) Eusebio Perdiguero et al.   JOURNAL OF CELL BIOLOGY

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

An Anti-Inflammatory Role for Carbon Monoxide and Heme Oxygenase-1 in Chronic Th2-Mediated Murine Colitis

(2011) S. Z. Sheikh et al.   JOURNAL OF IMMUNOLOGY

Evidence for an Anti-Inflammatory Loop Centered on Polymorphonuclear Leukocyte Formyl Peptide Receptor 2/Lipoxin A4 Receptor and Operative in the Inflamed Microvasculature

(2011) V. Brancaleone et al.   JOURNAL OF IMMUNOLOGY

Involvement of Adenosine A2A Receptors in Engulfment-Dependent Apoptotic Cell Suppression of Inflammation

(2011) K. Koroskenyi et al.   JOURNAL OF IMMUNOLOGY

Adenosine A2A receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation

(2011) Gabriela E. Garcia et al.   KIDNEY INTERNATIONAL

Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

(2011) Jeffrey L. Barnes et al.   KIDNEY INTERNATIONAL

PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

(2011) Ajit A. Kulkarni et al.   PLoS One

Pre-Treatment of Recombinant Mouse MFG-E8 Downregulates LPS-Induced TNF-α Production in Macrophages via STAT3-Mediated SOCS3 Activation

(2011) Monowar Aziz et al.   PLoS One

Phosphatidylserine Exposure by Toxoplasma gondii Is Fundamental to Balance the Immune Response Granting Survival of the Parasite and of the Host

(2011) Thiago Alves Teixeira dos Santos et al.   PLoS One

Hydrogen Sulfide Attenuates Carbon Tetrachloride-Induced Hepatotoxicity, Liver Cirrhosis and Portal Hypertension in Rats

(2011) Gang Tan et al.   PLoS One

Neutrophil clearance: when the party is over, clean-up begins

(2011) Donna L. Bratton et al.   TRENDS IN IMMUNOLOGY

Modulation of Macrophage Efferocytosis in Inflammation

(2011) Darlynn Korns et al.   Frontiers in Immunology

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

(2010) Charles N. Serhan   AMERICAN JOURNAL OF PATHOLOGY

Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players

(2010) Kristin Kruse et al.   APOPTOSIS

Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation

(2010) Takeshi Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

(2010) Christopher C. Rider et al.   BIOCHEMICAL JOURNAL

PPAR  activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease

(2010) R. Fernandez-Boyanapalli et al.   BLOOD

Glucocorticoids promote survival of anti-inflammatory macrophages via stimulation of adenosine receptor A3

(2010) K. Barczyk et al.   BLOOD

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

(2010) D. Barkan et al.   CANCER RESEARCH

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Soluble transforming growth factor-β1 receptor II might inhibit transforming growth factor-β-induced myofibroblast differentiation and improve ischemic cardiac function after myocardial infarction in rats

(2010) Ruiqing Lian et al.   CORONARY ARTERY DISEASE

Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis

(2010) Jun Wei et al.   CURRENT OPINION IN RHEUMATOLOGY

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids

(2010) Sagie Schif-Zuck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice

(2010) Tomohiro Yamada et al.   FASEB JOURNAL

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

(2010) Gang Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases and Attenuates IL-13-Dependent Fibrosis

(2010) S. K. Madala et al.   JOURNAL OF IMMUNOLOGY

Depletion of Regulatory T Cells Facilitates Growth of Established Tumors: A Mechanism Involving the Regulation of Myeloid-Derived Suppressor Cells by Lipoxin A4

(2010) B. Zhang et al.   JOURNAL OF IMMUNOLOGY

Regulation of Interleukin-10 Gene Expression in Macrophages Engulfing Apoptotic Cells

(2010) Yan Zhang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10

(2010) Emilio García-Prieto et al.   PLoS One

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relaxin inhibits early steps in vascular inflammation

(2010) Anna Brecht et al.   REGULATORY PEPTIDES

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Effects of Intravenous Sulfide During Porcine Aortic Occlusion-Induced Kidney Ischemia/Reperfusion Injury

(2010) Florian Simon et al.   SHOCK

CCN3/CCN2 regulation and the fibrosis of diabetic renal disease

(2010) Bruce L. Riser et al.   Journal of Cell Communication and Signaling

A novel role of CCN3 in regulating endothelial inflammation

(2010) Zhiyong Lin et al.   Journal of Cell Communication and Signaling

CCN3 (NOV) Is a Negative Regulator of CCN2 (CTGF) and a Novel Endogenous Inhibitor of the Fibrotic Pathway in an in Vitro Model of Renal Disease

(2009) Bruce L. Riser et al.   AMERICAN JOURNAL OF PATHOLOGY

Apoptotic and necrotic cells as sentinels of local tissue stress and inflammation: Response pathways initiated in nearby viable cells

(2009) Vimal A. Patel et al.   AUTOIMMUNITY

Relaxin stimulates osteoclast differentiation and activation

(2009) Alberto Ferlin et al.   BONE

Arginase: an emerging key player in the mammalian immune system

(2009) Markus Munder   BRITISH JOURNAL OF PHARMACOLOGY

Interaction of proteinase 3 with its associated partners: implications in the pathogenesis of Wegenerʼs granulomatosis

(2009) Véronique Witko-Sarsat et al.   CURRENT OPINION IN RHEUMATOLOGY

iC3b-opsonized apoptotic cells mediate a distinct anti-inflammatory response and transcriptional NF-κB-dependent blockade

(2009) Gil Amarilyo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: An in vivo study

(2009) Pinpat Tripatara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages

(2009) Kamran Atabai et al.   JOURNAL OF CLINICAL INVESTIGATION

ATLa, an Aspirin-Triggered Lipoxin A4 Synthetic Analog, Prevents the Inflammatory and Fibrotic Effects of Bleomycin-Induced Pulmonary Fibrosis

(2009) V. Martins et al.   JOURNAL OF IMMUNOLOGY

12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis

(2009) G. Kronke et al.   JOURNAL OF IMMUNOLOGY

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

Relaxin and its role in the development and treatment of fibrosis

(2009) Robert G. Bennett   Translational Research

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Carbon Monoxide Modulates α–Smooth Muscle Actin and Small Proline Rich-1a Expression in Fibrosis

(2008) Liang Zheng et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

The Inflammatory Response to Cell Death

(2008) Kenneth L. Rock et al.   Annual Review of Pathology-Mechanisms of Disease

Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4

(2008) R. F. Fernandez-Boyanapalli et al.   BLOOD

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Pathways connecting inflammation and cancer

(2008) Paola Allavena et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

(2008) Aksam J. Merched et al.   FASEB JOURNAL

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease

(2008) Michael Zeisberg et al.   PEDIATRIC NEPHROLOGY

RXFP1-inactive relaxin activates human glucocorticoid receptor: Further investigations into the relaxin–GR pathway

(2008) Thomas Dschietzig et al.   REGULATORY PEPTIDES

Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Suppresses Bleomycin-Induced Acute Lung Injury and Fibrosis

(2008) Yasuhiro Aoki et al.   RESPIRATION

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY