The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity

Immune Regulation of Metabolic Homeostasis in Health and Disease

(2015) Jonathan R. Brestoff et al.   CELL

Reducing RIP140 Expression in Macrophage Alters ATM Infiltration, Facilitates White Adipose Tissue Browning, and Prevents High-Fat Diet-Induced Insulin Resistance

(2014) P.-S. Liu et al.   DIABETES

A decade of progress in adipose tissue macrophage biology

(2014) Andrea A. Hill et al.   IMMUNOLOGICAL REVIEWS

Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution

(2013) J. S. Orr et al.   DIABETES

Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice

(2013) Viswanathan Saraswathi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

(2013) Takashi Satoh et al.   NATURE

PTGS-2-PTGER2/4 Signaling Pathway Partially Protects From Diabetogenic Toxicity of Streptozotocin in Mice

(2012) A. Vennemann et al.   DIABETES

Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin

(2012) M K Piya et al.   JOURNAL OF ENDOCRINOLOGY

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Prostaglandin E2 Regulates Pancreatic Stellate Cell Activity Via the EP4 Receptor

(2012) Chantale Charo et al.   PANCREAS

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps

(2011) Y. Nakanishi et al.   CARCINOGENESIS

Signaling via the prostaglandin E2 receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia

(2011) Xibin Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages

(2010) Fina Lovren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Deletion of EP4 on Bone Marrow–Derived Cells Enhances Inflammation and Angiotensin II–Induced Abdominal Aortic Aneurysm Formation

(2010) Eva H.C. Tang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions

(2010) E. H. C. Tang et al.   CARDIOVASCULAR RESEARCH

The Prostaglandin E2 E-Prostanoid 4 Receptor Exerts Anti-Inflammatory Effects in Brain Innate Immunity

(2010) J. Shi et al.   JOURNAL OF IMMUNOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action

(2009) Vijayalakshmi Varma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Prostaglandin EP2 and EP4 receptors modulate expression of the chemokine CCL2 (MCP-1) in response to LPS-induced renal glomerular inflammation

(2009) Gunther Zahner et al.   BIOCHEMICAL JOURNAL

Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization

(2009) Juichi Fukushima et al.   HEPATOLOGY RESEARCH

The Mechanism of Anti-Inflammatory Effects of Prostaglandin E2 Receptor 4 Activation in Murine Cardiac Transplantation

(2009) Masahito Ogawa et al.   TRANSPLANTATION

Pharmacological activation of the prostaglandin E2 receptor EP4 improves cardiac function after myocardial ischaemia/reperfusion injury

(2008) Keiichi Hishikari et al.   CARDIOVASCULAR RESEARCH

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Peroxisome Proliferator-activated Receptor γ Activation Promotes Infiltration of Alternatively Activated Macrophages into Adipose Tissue

(2008) Rinke Stienstra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostaglandin E Receptor Type 4-associated Protein Interacts Directly with NF-κB1 and Attenuates Macrophage Activation

(2008) Manabu Minami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY