Hypoxia, HIF, and Associated Signaling Networks in Chronic Kidney Disease

Critical role of the cAMP-PKA pathway in hyperglycemia-induced epigenetic activation of fibrogenic program in the kidney

(2017) Dilip K. Deb et al.   FASEB JOURNAL

Signalling pathways involved in hypoxia-induced renal fibrosis

(2017) Minna Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice

(2017) Shuo Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phase 2 studies of oral hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 for treatment of anemia in China

(2017) Nan Chen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Renal Hypoxia in CKD; Pathophysiology and Detecting Methods

(2017) Yosuke Hirakawa et al.   Frontiers in Physiology

A Novel Hypoxia-Inducible Factor−Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial

(2016) Richard A. Brigandi et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

New Treatment Approaches for the Anemia of CKD

(2016) Mario Bonomini et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Roxadustat (FG-4592) Versus Epoetin Alfa for Anemia in Patients Receiving Maintenance Hemodialysis: A Phase 2, Randomized, 6- to 19-Week, Open-Label, Active-Comparator, Dose-Ranging, Safety and Exploratory Efficacy Study

(2016) Robert Provenzano et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells

(2016) Natsuki Kushida et al.   AMERICAN JOURNAL OF NEPHROLOGY

Histone H2AK119 and H2BK120 mono-ubiquitination modulate SET7/9 and SUV39H1 in type 1 diabetes-induced renal fibrosis

(2016) S. K. Goru et al.   BIOCHEMICAL JOURNAL

Expanding roles of the hypoxia-response network in chronic kidney disease

(2016) Tetsuhiro Tanaka   Clinical and Experimental Nephrology

Hypoxia-Inducible Factor Stabilizers: a New Avenue for Reducing BP While Helping Hemoglobin?

(2016) Farhanah Yousaf et al.   CURRENT HYPERTENSION REPORTS

Emerging drugs for the treatment of kidney disease-induced anemia

(2016) Jolanta Malyszko et al.   EXPERT OPINION ON EMERGING DRUGS

Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin

(2016) Navid M. Farsijani et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin

(2016) Hanako Kobayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys

(2016) Yu-Ting Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Indoxyl sulfate suppresses endothelial progenitor cell–mediated neovascularization

(2016) Szu-Chun Hung et al.   KIDNEY INTERNATIONAL

Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

(2016) Bethany Baumann et al.   KIDNEY INTERNATIONAL

Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease

(2016) Pablo E. Pergola et al.   KIDNEY INTERNATIONAL

Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification

(2016) Sophie Mokas et al.   KIDNEY INTERNATIONAL

A mechanistic link between renal ischemia and fibrosis

(2016) Tetsuhiro Tanaka   Medical Molecular Morphology

Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis

(2016) Désirée Schönenberger et al.   Oncotarget

The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop

(2015) Sylwia Bartoszewska et al.   FASEB JOURNAL

Elevated Endothelial Hypoxia-Inducible Factor-1α Contributes to Glomerular Injury and Promotes Hypertensive Chronic Kidney DiseaseNovelty and Significance

(2015) Renna Luo et al.   HYPERTENSION

Kidney injury is independent of endothelial HIF-1α

(2015) Joanna Kalucka et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling

(2015) T. Souma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression

(2015) X. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients

(2015) A. Besarab et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammation and hypoxia in the kidney: friends or foes?

(2015) Volker H. Haase   KIDNEY INTERNATIONAL

Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ

(2015) Junna Yamaguchi et al.   KIDNEY INTERNATIONAL

Hypoxia-induced microRNA-155 promotes fibrosis in proximal tubule cells

(2015) SHENPING XIE et al.   Molecular Medicine Reports

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Anaemia in kidney disease: harnessing hypoxia responses for therapy

(2015) Mark J. Koury et al.   Nature Reviews Nephrology

HIF-1α and VEGF: Immunohistochemical Profile and Possible Function in Human Aortic Valve Stenosis

(2015) Ida Perrotta et al.   ULTRASTRUCTURAL PATHOLOGY

The relationship between serum hypoxia-inducible factor 1α and coronary artery calcification in asymptomatic type 2 diabetic patients

(2014) Gang Li et al.   Cardiovascular Diabetology

Endothelin-1 mediated high glucose-induced epithelial–mesenchymal transition in renal tubular cells

(2014) Lin Tang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

(2014) Pinelopi P. Kapitsinou et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-induced Bmi1 promotes renal tubular epithelial cell–mesenchymal transition and renal fibrosis via PI3K/Akt signal

(2014) Rui Du et al.   MOLECULAR BIOLOGY OF THE CELL

An acetate switch regulates stress erythropoiesis

(2014) Min Xu et al.   NATURE MEDICINE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Conditional inactivation of the mouse von Hippel–Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory and fibrotic lesions in the kidney

(2014) T L Pritchett et al.   ONCOGENE

Stable Expression of Hypoxia-Inducible Factor-1α in Human Renal Proximal Tubular Epithelial Cells Promotes Epithelial to Mesenchymal Transition

(2014) L. Luo et al.   TRANSPLANTATION PROCEEDINGS

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

Primary proximal tubule injury leads to epithelial cell cycle arrest, fibrosis, vascular rarefaction, and glomerulosclerosis

(2014) Joseph V. Bonventre   Kidney International Supplements

A hypoxia-inducible factor (HIF)-3α splicing variant, HIF-3α4 impairs angiogenesis in hypervascular malignant meningiomas with epigenetically silenced HIF-3α4

(2013) Hitoshi Ando et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial–mesenchymal transition in renal tubular cells

(2013) Wei-Qing Han et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of erythropoiesis by hypoxia-inducible factors

(2013) Volker H. Haase   BLOOD REVIEWS

Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by InducingP4HA1, P4HA2,andPLOD2Expression in Fibroblasts

(2013) Daniele M. Gilkes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of prolyl hydroxylase domain-containing protein on hypertension/renal injury induced by high salt diet and nitric oxide withdrawal

(2013) Mohammad K. Dallatu et al.   JOURNAL OF HYPERTENSION

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

(2013) Peter J. Ratcliffe   JOURNAL OF PHYSIOLOGY-LONDON

Angiogenesis and hypoxia in the kidney

(2013) Tetsuhiro Tanaka et al.   Nature Reviews Nephrology

HIF-1  is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2 -induced excessive erythropoiesis

(2012) K. Franke et al.   BLOOD

Vascular Calcification: Pathophysiology and Risk Factors

(2012) Neal X. Chen et al.   CURRENT HYPERTENSION REPORTS

The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling

(2012) Rui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes

(2012) Nicolas Skuli et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid Cell-Derived Hypoxia-Inducible Factor Attenuates Inflammation in Unilateral Ureteral Obstruction-Induced Kidney Injury

(2012) H. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation

(2012) Chiao-Yin Sun et al.   KIDNEY INTERNATIONAL

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

(2012) Ivica Grgic et al.   KIDNEY INTERNATIONAL

Prevalence of chronic kidney disease in China: a cross-sectional survey

(2012) Luxia Zhang et al.   LANCET

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bone Gla Protein Increases HIF-1α–Dependent Glucose Metabolism and Induces Cartilage and Vascular Calcification

(2011) Anna Idelevich et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

(2011) Minna Heikkilä et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Silencing of Hypoxia-Inducible Factor-1α Gene Attenuated Angiotensin II–Induced Renal Injury in Sprague-Dawley Rats

(2011) Qing Zhu et al.   HYPERTENSION

Herpesvirus entry mediator regulates hypoxia-inducible factor–1α and erythropoiesis in mice

(2011) Yukimi Sakoda et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

(2011) Nariaki Asada et al.   JOURNAL OF CLINICAL INVESTIGATION

Specific Contribution of the Erythropoietin Gene 3' Enhancer to Hepatic Erythropoiesis after Late Embryonic Stages

(2011) N. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

(2010) P. P. Kapitsinou et al.   BLOOD

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

(2010) Muh-Hwa Yang et al.   CELL CYCLE

Epigenetic Histone Methylation Modulates Fibrotic Gene Expression

(2010) G. Sun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anemia management in chronic kidney disease

(2010) Steven Fishbane et al.   KIDNEY INTERNATIONAL

Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells

(2010) Zhengchao Wang et al.   KIDNEY INTERNATIONAL

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Erythropoiesis-Stimulating Agents — Time for a Reevaluation

(2010) Ellis F. Unger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss

(2010) Y. A. Minamishima et al.   SCIENCE

Effects of Increased Renal Tubular Vascular Endothelial Growth Factor (VEGF) on Fibrosis, Cyst Formation, and Glomerular Disease

(2009) Samy Hakroush et al.   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Phosphatidylinositol-3-Kinase/Akt Regulates Bleomycin-Induced Fibroblast Proliferation and Collagen Production

(2009) Yongju Lu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The humanHIF(hypoxia-inducible factor)-3α gene is a HIF-1 target gene and may modulate hypoxic gene induction

(2009) Tetsuhiro Tanaka et al.   BIOCHEMICAL JOURNAL

HIF in Kidney Disease and Development

(2009) L. Gunaratnam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vascular Calcification: The Killer of Patients with Chronic Kidney Disease

(2009) M. Mizobuchi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypoxia-inducible factor-1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition

(2009) Shiren Sun et al.   KIDNEY INTERNATIONAL

The emerging role of phosphate in vascular calcification

(2009) Cecilia M. Giachelli   KIDNEY INTERNATIONAL

Hypoxia-inducible factor-2α-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization

(2009) Alexander Paliege et al.   KIDNEY INTERNATIONAL

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Oxygen homeostasis

(2009) Gregg L. Semenza   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Repression via the GATA box is essential for tissue-specific erythropoietin gene expression

(2008) N. Obara et al.   BLOOD

Auto-hydroxylation of FIH-1: an Fe(ii), α-ketoglutarate-dependent human hypoxia sensor

(2008) Yuan-Han Chen et al.   CHEMICAL COMMUNICATIONS

Dialysis Accelerates Medial Vascular Calcification in Part by Triggering Smooth Muscle Cell Apoptosis

(2008) Rukshana C. Shroff et al.   CIRCULATION

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL