Expanding roles of the hypoxia-response network in chronic kidney disease

Kidney injury is independent of endothelial HIF-1α

(2015) Joanna Kalucka et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients

(2015) A. Besarab et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ

(2015) Junna Yamaguchi et al.   KIDNEY INTERNATIONAL

The contribution of epithelial-mesenchymal transition to renal fibrosis differs among kidney disease models

(2015) Tsutomu Inoue et al.   KIDNEY INTERNATIONAL

Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients

(2015) Anatole Besarab et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

(2014) Pinelopi P. Kapitsinou et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy

(2014) L. Nordquist et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Adipose Tissue-Derived Mesenchymal Stem Cells in Long-Term Dialysis Patients Display Downregulation of PCAF Expression and Poor Angiogenesis Activation

(2014) Shuichiro Yamanaka et al.   PLoS One

Up-regulation of glycolytic metabolism is required for HIF1 -driven bone formation

(2014) J. N. Regan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes

(2014) Takahisa Kawakami et al.   Kidney International Supplements

Sperm-Associated Antigen 4, a Novel Hypoxia-Inducible Factor 1 Target, Regulates Cytokinesis, and Its Expression Correlates with the Prognosis of Renal Cell Carcinoma

(2013) Kumi Shoji et al.   AMERICAN JOURNAL OF PATHOLOGY

Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia

(2013) Tetsuhiro Tanaka et al.   FASEB JOURNAL

Kidney Hypoxia, Attributable to Increased Oxygen Consumption, Induces Nephropathy Independently of Hyperglycemia and Oxidative Stress

(2013) Malou Friederich-Persson et al.   HYPERTENSION

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

A mouse model of adult-onset anaemia due to erythropoietin deficiency

(2013) Shun Yamazaki et al.   Nature Communications

Selective Stabilization of HIF-1α in Renal Tubular Cells by 2-Oxoglutarate Analogues

(2012) Gunnar Schley et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of hypoxia-inducible factor in kidney disease

(2012) Masaomi Nangaku et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Anthracycline Inhibits Recruitment of Hypoxia-inducible Transcription Factors and Suppresses Tumor Cell Migration and Cardiac Angiogenic Response in the Host

(2012) Tetsuhiro Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid Cell-Derived Hypoxia-Inducible Factor Attenuates Inflammation in Unilateral Ureteral Obstruction-Induced Kidney Injury

(2012) H. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts

(2012) Ruth E. Schietke et al.   PLoS One

Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1 

(2011) L. Fu et al.   CANCER RESEARCH

Noninvasive evaluation of renal oxygenation in diabetic nephropathy by BOLD-MRI

(2011) Wen-Jie Yin et al.   EUROPEAN JOURNAL OF RADIOLOGY

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

(2011) Wilhelm Kriz et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Inducible Transcription Factors Stabilization in the Thick Ascending Limb Protects against Ischemic Acute Kidney Injury

(2011) G. Schley et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Noninvasive Evaluation of Kidney Hypoxia and Fibrosis Using Magnetic Resonance Imaging

(2011) T. Inoue et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner

(2011) Chih-Kang Chiang et al.   LABORATORY INVESTIGATION

Transient hypoxia-inducible factor activation in rat renal ablation and reduced fibrosis with L-mimosine

(2011) XIAOFANG YU et al.   NEPHROLOGY

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetic variant of hypoxia-inducible factor-1α is associated with adverse outcomes in acute kidney injury

(2009) Alexey Y. Kolyada et al.   KIDNEY INTERNATIONAL

Hypoxia response and VEGF-A expression in human proximal tubular epithelial cells in stable and progressive renal disease

(2009) Michael Rudnicki et al.   LABORATORY INVESTIGATION

A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo

(2009) Y. A. Minamishima et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney

(2009) Y. R. Song et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

(2009) W. M. Bernhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreasing Intracellular Superoxide Corrects Defective Ischemia-induced New Vessel Formation in Diabetic Mice

(2008) Daniel J. Ceradini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury

(2008) P. Hill et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HIF Activation Protects From Acute Kidney Injury

(2008) A. Weidemann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Adaptation to hypoxia in the diabetic rat kidney

(2007) C. Rosenberger et al.   KIDNEY INTERNATIONAL