A mechanistic link between renal ischemia and fibrosis

Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia

(2015) L. Holdstock et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients

(2015) A. Besarab et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ

(2015) Junna Yamaguchi et al.   KIDNEY INTERNATIONAL

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond

(2015) Patrick H. Maxwell et al.   Nature Reviews Nephrology

Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients

(2015) Anatole Besarab et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

(2014) Pinelopi P. Kapitsinou et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy

(2014) L. Nordquist et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A genetic mechanism for Tibetan high-altitude adaptation

(2014) Felipe R Lorenzo et al.   NATURE GENETICS

Adipose Tissue-Derived Mesenchymal Stem Cells in Long-Term Dialysis Patients Display Downregulation of PCAF Expression and Poor Angiogenesis Activation

(2014) Shuichiro Yamanaka et al.   PLoS One

Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia

(2013) Tetsuhiro Tanaka et al.   FASEB JOURNAL

Kidney Hypoxia, Attributable to Increased Oxygen Consumption, Induces Nephropathy Independently of Hyperglycemia and Oxidative Stress

(2013) Malou Friederich-Persson et al.   HYPERTENSION

Angiogenesis and hypoxia in the kidney

(2013) Tetsuhiro Tanaka et al.   Nature Reviews Nephrology

Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy

(2013) Nazmul Haque et al.   TheScientificWorldJOURNAL

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

(2012) Ivica Grgic et al.   KIDNEY INTERNATIONAL

Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts

(2012) Ruth E. Schietke et al.   PLoS One

Noninvasive Evaluation of Kidney Hypoxia and Fibrosis Using Magnetic Resonance Imaging

(2011) T. Inoue et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner

(2011) Chih-Kang Chiang et al.   LABORATORY INVESTIGATION

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HIF-Prolyl Hydroxylases in the Rat Kidney

(2009) Johannes Schödel et al.   AMERICAN JOURNAL OF PATHOLOGY

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

(2009) W. M. Bernhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitric oxide and kidney oxygenation

(2008) Fredrik Palm et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Decreasing Intracellular Superoxide Corrects Defective Ischemia-induced New Vessel Formation in Diabetic Mice

(2008) Daniel J. Ceradini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD

Adaptation to hypoxia in the diabetic rat kidney

(2007) C. Rosenberger et al.   KIDNEY INTERNATIONAL