Metformin Potentiates the Benefits of Dietary Restraint: A Metabolomic Study

Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users

(2017) Fedra Luciano-Mateo et al.   Nutrients

Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue

(2017) Charles Caër et al.   Scientific Reports

Metformin causes a futile intestinal–hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state

(2017) Philipp Schommers et al.   Molecular Metabolism

Combined metformin and insulin treatment reverses metabolically impaired omental adipogenesis and accumulation of 4-hydroxynonenal in obese diabetic patients

(2017) Morana Jaganjac et al.   Redox Biology

Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling

(2016) Zi-yu Zhou et al.   ACTA PHARMACOLOGICA SINICA

Treatment of nonalcoholic fatty liver disease: role of AMPK

(2016) Brennan K. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Metformin administration induces hepatotoxic effects in paraoxonase-1-deficient mice

(2016) Anabel García-Heredia et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Metformin for Prevention and Treatment of Colon Cancer: A Reappraisal of Experimental and Clinical Data

(2016) Vladimir N. Anisimov   CURRENT DRUG TARGETS

Epigenetics and nutrition-related epidemics of metabolic diseases: Current perspectives and challenges

(2016) Anna Hernández-Aguilera et al.   FOOD AND CHEMICAL TOXICOLOGY

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Metformin and cancer: Quo vadis et cui bono?

(2016) Javier A. Menendez et al.   Oncotarget

Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based “starvation” strategies in BRCA1 carriers

(2016) Elisabet Cuyàs et al.   Oncotarget

Inferring propagation paths for sparsely observed perturbations on complex networks

(2016) F. A. Massucci et al.   Science Advances

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

(2016) Bruna Corominas-Faja et al.   Aging-US

One-carbon metabolism: An aging-cancer crossroad for the gerosuppressant metformin

(2016) Javier A. Menendez et al.   Aging-US

Manipulation of health span and function by dietary caloric restriction mimetics

(2015) George S. Roth et al.   Annals of the New York Academy of Sciences

Combining metformin therapy with caloric restriction for the management of type 2 diabetes and nonalcoholic fatty liver disease in obese rats

(2015) Melissa A. Linden et al.   Applied Physiology Nutrition and Metabolism

Drugs Commonly Associated With Weight Change: A Systematic Review and Meta-analysis

(2015) Juan Pablo Domecq et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Exploring the Process of Energy Generation in Pathophysiology by Targeted Metabolomics: Performance of a Simple and Quantitative Method

(2015) Marta Riera-Borrull et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

(2015) Courtney R Green et al.   Nature Chemical Biology

Metformin takes a new route to clinical efficacy

(2015) Marc Foretz et al.   Nature Reviews Endocrinology

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages

(2015) Ling Ding et al.   Oncotarget

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

(2015) Takla Griss et al.   PLOS BIOLOGY

Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect

(2015) Yoshifumi Saisho   Endocrine Metabolic & Immune Disorders-Drug Targets

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin

(2015) Silvia Cufi et al.   Oncotarget

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Metformin Ameliorates Hepatic Steatosis and Inflammation without Altering Adipose Phenotype in Diet-Induced Obesity

(2014) Shih-Lung Woo et al.   PLoS One

Metformin: Do we finally have an anti-aging drug?

(2013) Vladimir N. Anisimov   CELL CYCLE

Paraoxonase-1 Deficiency Is Associated with Severe Liver Steatosis in Mice Fed a High-fat High-cholesterol Diet: A Metabolomic Approach

(2013) Anabel García-Heredia et al.   JOURNAL OF PROTEOME RESEARCH

Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice

(2012) Jorge Joven et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

(2012) Santhosh Satapati et al.   JOURNAL OF LIPID RESEARCH

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels

(2010) Mark A. Herman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY