Review
Biochemistry & Molecular Biology
Teodor Paul Kacso, Renata Zahu, Alexandru Tirpe, Elina Valeria Paslari, Andreea Nutu, Ioana Berindan-Neagoe
Summary: This article discusses the mechanisms by which lncRNAs regulate ROS levels in cancer cells. Firstly, lncRNAs are involved in the coordinated antioxidant response of cancer cells through the nuclear factor like 2 pathway. Secondly, lncRNAs promote the Warburg effect in cancer cells, redirecting the cancer cell metabolism towards molecules important in oxidative stress regulation. Lastly, lncRNAs play a role in ROS-induced cancer cell apoptosis and proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Vincenza Ylenia Cusenza, Elena Bonora, Nicola Amodio, Raffaele Frazzi
Summary: SPART is a gene that encodes a multifunctional protein, spartin, which is found in various organelles of human cells. Mutations in this gene can cause a hereditary form of spastic paraplegia called Troyer syndrome, while epigenetic silencing has been observed in certain types of tumors. The gene's main functions include endosomal trafficking and receptor degradation, microtubule interaction, cytokinesis, fatty acid metabolism, and oxidative metabolism. Recent research has shown that spartin is downregulated in tumor tissues compared to adjacent normal samples. This finding provides intriguing evidence for further investigation into the role of this protein in cancer development and metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Oncology
Ying Dong, Yingbei Qi, Haowen Jiang, Tian Mi, Yunkai Zhang, Chang Peng, Wanchen Li, Yongmei Zhang, Yubo Zhou, Yi Zang, Jia Li
Summary: Metformin has been widely used for treating type II diabetes due to its safety, low cost, and effective hypoglycemic effects. It works by inhibiting mitochondrial respiratory-chain complex I and activating AMP-activated protein kinase (AMPK). In recent years, there has been increasing research on the potential benefits of metformin in metabolic diseases, cancer, aging, and neurological disorders.
FRONTIERS OF MEDICINE
(2023)
Review
Chemistry, Medicinal
Sarah J. Skuli, Safwan Alomari, Hallie Gaitsch, A'ishah Bakayoko, Nicolas Skuli, Betty M. Tyler
Summary: Metformin, as a drug, not only reduces the risk of cancer in type 2 diabetics but also inhibits cell growth in various cancers. However, its mechanism of action in cancer cells and its effect on cancer metabolism are still unclear.
Review
Nutrition & Dietetics
Sapna Virdi, Abbey M. Mckee, Manogna Nuthi, Nafisa M. Jadavji
Summary: Dietary supplementation of 1C components such as folic acid, vitamin B12, and choline has positive effects on healthy aging by integrating nutritional signals with multiple processes in the human body. Considerations for promoting healthy aging through dietary supplementation include using precision medicine for individualized plans, avoiding over-supplementation, and combining therapies.
Review
Biochemistry & Molecular Biology
Wenfeng Zeng, Xiaozhe Yin, Yunhan Jiang, Lingtao Jin, Wei Liang
Summary: The dysregulated lipid metabolism in cancer has attracted attention, with immune cells and cancer cells competing for nutrients in the tumor microenvironment. Reprogramming of lipid metabolism towards fatty acid oxidation is closely linked to the immunosuppressive phenotype of tumor-infiltrated immune cells.
Review
Biochemistry & Molecular Biology
Yu Takeda, Ryota Chijimatsu, Andrea Vecchione, Takahiro Arai, Toru Kitagawa, Ken Ofusa, Masami Yabumoto, Takaaki Hirotsu, Hidetoshi Eguchi, Yuichiro Doki, Hideshi Ishii
Summary: The article highlights the importance of one-carbon metabolism in cancer research related to the folate cycle, discussing recent advances in understanding cellular biochemical reactions and reactive oxygen species in cancer cells. Further research is needed to explore therapeutic drug discovery and develop precision cancer medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Sijing Pan, Ming Fan, Zhangnan Liu, Xia Li, Huijuan Wang
Summary: Serine/glycine biosynthesis and one-carbon metabolism play crucial roles in sustaining cancer cell survival and proliferation by providing essential macromolecules and maintaining redox balance in the tumor microenvironment. Understanding the regulatory mechanisms of key enzymes and intermediates in these pathways may lead to new opportunities for cancer drug development, dietary interventions, and biomarker identification.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Cell Biology
Dionysios Xenos, Patrizia Mecocci, Virginia Boccardi
Summary: Metformin has shown potential in extending healthspan and lifespan in humans, based on evidence from lower organisms and mice. Further analysis of ongoing clinical trials may provide definitive answers on its role beyond treating T2DM.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Review
Oncology
Wei Sun, Erhu Zhao, Hongjuan Cui
Summary: Cancer cells selectively utilize serine or synthesize serine for nucleotide biosynthesis. The serine-glycine-one-carbon metabolism (SGOC) pathway plays a crucial role in tumorigenesis. Accumulating evidence shows that metabolic enzymes in the SGOC pathway are involved in tumor development and drug resistance. This review focuses on the involvement of serine and glycine in the folate-mediated one-carbon pathway, as well as the effects of SGOC metabolic enzymes on tumor occurrence and drug resistance.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Fubin Liu, Huijun Zhou, Yu Peng, Yating Qiao, Peng Wang, Changyu Si, Xixuan Wang, Jianxiao Gong, Kexin Chen, Fangfang Song
Summary: This study conducted a case-control study in China and found a negative association between plasma one-carbon metabolism-related micronutrients and breast cancer risk, mediated by DNA methylation. The selected differential methylation probes were found to mediate the associations between micronutrients and breast cancer risk.
Review
Oncology
Elisabet Cuyas, Sara Verdura, Begona Martin-Castillo, Javier A. Menendez
Summary: Research suggests that the anti-diabetic drug metformin can modulate the chromatin state of cancer cells, affecting their function. Metformin has the ability to target global metabolic pathways or specific metabolic enzymes, regulating the production of chromatin-modifying metabolites, and indirectly or directly adjusting the activation status of chromatin-modifying enzymes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Physiology
Shama R. Iyer, Eric S. Folker, Richard M. Lovering
Summary: Intermediate filaments (IFs) are crucial components of the cytoskeleton and are essential for mechanotransduction in muscle cells. The nucleus acts as the endpoint for the transmission of force, with the nuclear lamina playing a key role in responding to mechanical input. Understanding how the nucleus responds to its mechanical environment is of great interest, especially in skeletal muscle cells where extreme mechanical forces are generated during muscle contraction.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Chemistry, Medicinal
Tyler Sniegowski, Ksenija Korac, Yangzom D. Bhutia, Vadivel Ganapathy
Summary: Glutaminolysis and serine-glycine-one-carbon pathways in cancer cells are reprogrammed and upregulated to support the growth and proliferation of cancer cells. These pathways play crucial roles in the synthesis of purines, pyrimidines, and epigenetic modifications, with methionine being essential for methyl-transfer reactions.
Review
Cell Biology
Eirini Lionaki, Christina Ploumi, Nektarios Tavernarakis
Summary: One-carbon metabolism is a biochemical network that delivers one-carbon units to biosynthetic pathways. It plays a crucial role in cellular proliferation, homeostasis, energy regulation, and longevity.
