Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation

Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance

(2017) Hiroko Izumi-Nakaseko et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system

(2017) Huanqi Zhu et al.   Scientific Reports

Erratum: Identification of Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides

(2017) Cai Hong Koh et al.   Scientific Reports

Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes

(2017) Hendrik Lapp et al.   Scientific Reports

Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature

(2016) Igho J. Onakpoya et al.   BMC Medicine

Extracellular Matrix–Mediated Maturation of Human Pluripotent Stem Cell–Derived Cardiac Monolayer Structure and Electrophysiological Function

(2016) Todd J. Herron et al.   Circulation-Arrhythmia and Electrophysiology

Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations

(2016) Tobias Bruegmann et al.   JOURNAL OF CLINICAL INVESTIGATION

The Use of Ratiometric Fluorescence Measurements of the Voltage Sensitive Dye Di-4-ANEPPS to Examine Action Potential Characteristics and Drug Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2016) M. P. Hortigon-Vinagre et al.   TOXICOLOGICAL SCIENCES

OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology

(2016) Aleksandra Klimas et al.   Nature Communications

Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging

(2016) Graham T. Dempsey et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

CSAHi study: Evaluation of multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia — Effects of 7 reference compounds at 10 facilities

(2016) Takashi Kitaguchi et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes

(2016) Jukka Kuusela et al.   SpringerPlus

Systemic gene transfer enables optogenetic pacing of mouse hearts

(2015) C. C. Vogt et al.   CARDIOVASCULAR RESEARCH

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

(2015) Dario Melgari et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Proarrhythmia Risk Assessment in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using the Maestro MEA Platform

(2015) Yusheng Qu et al.   TOXICOLOGICAL SCIENCES

Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment

(2015) Mike Clements et al.   TOXICOLOGICAL SCIENCES

High-throughput cardiac safety evaluation and multi-parameter arrhythmia profiling of cardiomyocytes using microelectrode arrays

(2015) Kristin H. Gilchrist et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes

(2015) Keiichi Asakura et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Screening for Acute I Kr Block Is Insufficient to Detect Torsades de Pointes Liability

(2014) Tao Yang et al.   CIRCULATION

CRISPR/Cas9 for genome editing: progress, implications and challenges

(2014) F. Zhang et al.   HUMAN MOLECULAR GENETICS

High-Throughput Multi-Parameter Profiling of Electrophysiological Drug Effects in Human Embryonic Stem Cell Derived Cardiomyocytes Using Multi-Electrode Arrays

(2014) Mike Clements et al.   TOXICOLOGICAL SCIENCES

Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation

(2014) Yumiko Nozaki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip

(2014) Tomoyuki Kaneko et al.   Scientific Reports

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays

(2013) E. G. Navarrete et al.   CIRCULATION

Mechanism-Based Facilitated Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes

(2013) Deborah K. Lieu et al.   Circulation-Arrhythmia and Electrophysiology

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

(2013) Sara S Nunes et al.   NATURE METHODS

Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity

(2013) Nicola Ferri et al.   PHARMACOLOGY & THERAPEUTICS

Comparison of Electrophysiological Data From Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes to Functional Preclinical Safety Assays

(2013) Kate Harris et al.   TOXICOLOGICAL SCIENCES

Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform

(2012) Antje D. Ebert et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Suppression of Phosphoinositide 3-Kinase Signaling and Alteration of Multiple Ion Currents in Drug-Induced Long QT Syndrome

(2012) Z. Lu et al.   Science Translational Medicine

A Review of Human Pluripotent Stem Cell-Derived Cardiomyocytes for High-Throughput Drug Discovery, Cardiotoxicity Screening, and Publication Standards

(2012) Nicholas M. Mordwinkin et al.   Journal of Cardiovascular Translational Research

Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species

(2011) Thomas O'Hara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Electrophysiological Effects of Cardiac Glycosides in Human iPSC-derived Cardiomyocytes and in Guinea Pig Isolated Hearts

(2011) Liang Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Genetics of sudden death: focus on inherited channelopathies

(2011) M. Cerrone et al.   EUROPEAN HEART JOURNAL

Drug-Induced Long QT Syndrome

(2010) P. Kannankeril et al.   PHARMACOLOGICAL REVIEWS

The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells

(2009) Noritaka Yokoo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

(2009) Stefan R. Braam et al.   Stem Cell Research