Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment

CiPA: Ongoing testing, future qualification procedures, and pending issues

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Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

(2015) J. Vicente et al.   Journal of the American Heart Association

Rosiglitazone Causes Cardiotoxicity via Peroxisome Proliferator-Activated Receptor γ-Independent Mitochondrial Oxidative Stress in Mouse Hearts

(2014) Huamei He et al.   TOXICOLOGICAL SCIENCES

A Multi-parameter In Vitro Screen in Human Stem Cell-Derived Cardiomyocytes Identifies Ponatinib-Induced Structural and Functional Cardiac Toxicity

(2014) Dominique R. Talbert et al.   TOXICOLOGICAL SCIENCES

High-Throughput Multi-Parameter Profiling of Electrophysiological Drug Effects in Human Embryonic Stem Cell Derived Cardiomyocytes Using Multi-Electrode Arrays

(2014) Mike Clements et al.   TOXICOLOGICAL SCIENCES

Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation

(2014) Yumiko Nozaki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip

(2014) Tomoyuki Kaneko et al.   Scientific Reports

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Refining the Human iPSC-Cardiomyocyte Arrhythmic Risk Assessment Model

(2013) Liang Guo et al.   TOXICOLOGICAL SCIENCES

Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity

(2013) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Comparison of Electrophysiological Data From Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes to Functional Preclinical Safety Assays

(2013) Kate Harris et al.   TOXICOLOGICAL SCIENCES

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

(2013) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system

(2013) Nadine Becker et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Blockade of human HERG K+ channels by rosiglitazone, an antidiabetic drug

(2012) Seung Ho Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Characterization of Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening

(2012) Payal Rana et al.   TOXICOLOGICAL SCIENCES

Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment

(2011) Yama A Abassi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations

(2011) J.D. Cohen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dissolution and pharmacokinetics of a novel micronized aspirin formulation

(2011) M. Voelker et al.   INFLAMMOPHARMACOLOGY

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

(2010) Shengde Peng et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for IKs

(2009) J Ducroq et al.   BRITISH JOURNAL OF PHARMACOLOGY

The future of drug safety testing: expanding the view and narrowing the focus

(2009) James L. Stevens et al.   DRUG DISCOVERY TODAY

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model

(2008) X Yao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Electrophysiological safety of sibutramine HCl

(2008) KS Kim et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Mechanisms of Zidovudine-Induced Mitochondrial Toxicity and Myopathy

(2008) Erin R. Scruggs et al.   PHARMACOLOGY

In Vitro Electrophysiological Drug Testing Using Human Embryonic Stem Cell Derived Cardiomyocytes

(2008) Oren Caspi et al.   STEM CELLS AND DEVELOPMENT