Suppression of Phosphoinositide 3-Kinase Signaling and Alteration of Multiple Ion Currents in Drug-Induced Long QT Syndrome

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Tyrosine Kinase Inhibitors: The First Decade

(2010) Meetu Agrawal et al.   Current Hematologic Malignancy Reports

Loss of Cardiac Phosphoinositide 3-Kinase p110α Results in Contractile Dysfunction

(2009) Zhongju Lu et al.   CIRCULATION

The genetic basis of long QT and short QT syndromes: A mutation update

(2009) Paula L. Hedley et al.   HUMAN MUTATION

Cardiovascular Complications of Cancer Therapy

(2009) Edward T.H. Yeh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

hERG Potassium Channels and the Structural Basis of Drug-Induced Arrhythmias

(2008) John S. Mitcheson   CHEMICAL RESEARCH IN TOXICOLOGY

Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and Suppresses Ventricular Arrhythmia

(2008) David H. Lau et al.   CIRCULATION

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Mouse models of SCN5A-related cardiac arrhythmias

(2008) Flavien Charpentier et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY