IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
Authors
Keywords
EMT, IGF-I, IGF-IR, Metastasis, Therapy
Journal
Molecular Cancer
Volume 16, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-01-13
DOI
10.1186/s12943-016-0576-5
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Insulin–Insulin-like Growth Factors Hybrids as Molecular Probes of Hormone:Receptor Binding Specificity
- (2016) Květoslava Křížková et al. BIOCHEMISTRY
- A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
- (2016) Ruth C. Travis et al. CANCER RESEARCH
- Preclinical and first-in-human phase I studies of KW-2450, an oral tyrosine kinase inhibitor with insulin-like growth factor receptor-1/insulin receptor selectivity
- (2016) Gary K. Schwartz et al. CANCER SCIENCE
- EMT: 2016
- (2016) M. Angela Nieto et al. CELL
- Circulating Insulin-Like Growth Factor-1 Level and Ovarian Cancer Risk
- (2016) Yiyang Li et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R
- (2016) Klaas de Lint et al. MOLECULAR CANCER THERAPEUTICS
- IGF-I Induces Epithelial-to-Mesenchymal Transition via the IGF-IR-Src-MicroRNA-30a-E-Cadherin Pathway in Nasopharyngeal Carcinoma Cells
- (2016) Ruoyu Wang et al. ONCOLOGY RESEARCH
- IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer
- (2016) Chao Yao et al. STEM CELLS
- The insulin-like growth factor-I receptor (IGF-IR) in breast cancer: biology and treatment strategies
- (2016) Morteza Motallebnezhad et al. TUMOR BIOLOGY
- Insulin, insulin receptors, and cancer
- (2016) R. Vigneri et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- A polymorphic repeat in theIGF1promoter influences the risk of endometrial cancer
- (2016) Katherine A Bolton et al. Endocrine Connections
- A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the GAMMA trial†
- (2015) C. S. Fuchs et al. ANNALS OF ONCOLOGY
- Abstract P2-07-05: A potential role for Janus protein tyrosine kinases in the regulation of epithelial-mesenchymal transition in a model of epidermal growth factor induced breast cancer epithelial-mesenchymal transition
- (2015) Teneale A Stewart et al. CANCER RESEARCH
- IGF-1R expression is associated with HPV-negative status and adverse survival in head and neck squamous cell cancer
- (2015) O. T. Dale et al. CARCINOGENESIS
- Clinical and Translational Results of a Phase II, Randomized Trial of an Anti-IGF-1R (Cixutumumab) in Women with Breast Cancer That Progressed on Endocrine Therapy
- (2015) W. J. Gradishar et al. CLINICAL CANCER RESEARCH
- Interplay between microRNAs and WNT/β-catenin signalling pathway regulates epithelial–mesenchymal transition in cancer
- (2015) Nastaran Mohammadi Ghahhari et al. EUROPEAN JOURNAL OF CANCER
- Safety, tolerability, and pharmacokinetics of single and multiple doses of intravenous cixutumumab (IMC-A12), an inhibitor of the insulin-like growth factor-I receptor, administered weekly or every 2 weeks in patients with advanced solid tumors
- (2015) C. S. Higano et al. INVESTIGATIONAL NEW DRUGS
- Clinical significance of IGF1R gene expression in patients with Stage II/III gastric cancer who receive curative surgery and adjuvant chemotherapy with S-1
- (2015) Koji Numata et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- A Randomized Phase II/III Study of Dalotuzumab in Combination With Cetuximab and Irinotecan in Chemorefractory,KRASWild-Type, Metastatic Colorectal Cancer
- (2015) Francesco Sclafani et al. JNCI-Journal of the National Cancer Institute
- Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study
- (2015) Martin Fassnacht et al. LANCET ONCOLOGY
- Expression of insulin-like growth factor 1 receptor (IGF-1R) predicts poor responses to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer patients harboring activating EGFR mutations
- (2015) Chang Dong Yeo et al. LUNG CANCER
- Minireview: Were the IGF Signaling Inhibitors All Bad?
- (2015) Heather Beckwith et al. MOLECULAR ENDOCRINOLOGY
- Regulation of complement-dependent cytotoxicity by TGF-β-induced epithelial–mesenchymal transition
- (2015) M T Goswami et al. ONCOGENE
- The involvement of survivin in insulin-like growth factor 1-induced epithelial-mesenchymal transition in gastric cancer
- (2015) Chengjun Li et al. TUMOR BIOLOGY
- FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells
- (2015) LaTonia Taliaferro-Smith et al. Oncotarget
- The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis
- (2015) Lingyun Zhang et al. Oncotarget
- EMT, CTCs and CSCs in tumor relapse and drug-resistance
- (2015) Abhisek Mitra et al. Oncotarget
- A Randomized Phase II/III Study of Dalotuzumab in Combination With Cetuximab and Irinotecan in Chemorefractory,KRASWild-Type, Metastatic Colorectal Cancer
- (2015) Francesco Sclafani et al. JNCI-Journal of the National Cancer Institute
- Crosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast Cancer
- (2015) Lauren M. Rota et al. Frontiers in Endocrinology
- Abstract 1741: Inhibition of type 1 insulin-like growth factor receptor (IGF-1R) influences processing of replication-associated DNA double-strand breaks (DSBs) and induces schedule-dependent sensitization of human melanoma to temozolomide (TMZ)
- (2015) Roger N. Ramcharan et al. CANCER RESEARCH
- Upregulation of IGF-1R Expression during Neoadjuvant Therapy Predicts Poor Outcome in Breast Cancer Patients
- (2015) Sandra Heskamp et al. PLoS One
- Breast cancer stem cells, EMT and therapeutic targets
- (2014) Srishti Kotiyal et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: Phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWO
- (2014) Philip A. Philip et al. CANCER
- IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells
- (2014) Ram K. Singh et al. CANCER LETTERS
- IGF1R Inhibition in Mammary Epithelia Promotes Canonical Wnt Signaling and Wnt1-Driven Tumors
- (2014) L. M. Rota et al. CANCER RESEARCH
- IGF-1-induced epithelial–mesenchymal transition in MCF-7 cells is mediated by MUC1
- (2014) Gaoyong Liao et al. CELLULAR SIGNALLING
- Functional Genetic Approach Identifies MET, HER3, IGF1R, INSR Pathways as Determinants of Lapatinib Unresponsiveness in HER2-Positive Gastric Cancer
- (2014) Z. Zhang et al. CLINICAL CANCER RESEARCH
- The Role of Snail in EMT and Tumorigenesis
- (2014) Yifan Wang et al. CURRENT CANCER DRUG TARGETS
- Insulin Receptor Substrate 1/2 (IRS1/2) Regulates Wnt/β-Catenin Signaling through Blocking Autophagic Degradation of Dishevelled2
- (2014) Yongtao Geng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Randomized, Phase III Trial of First-Line Figitumumab in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone in Patients With Advanced Non–Small-Cell Lung Cancer
- (2014) Corey J. Langer et al. JOURNAL OF CLINICAL ONCOLOGY
- MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance
- (2014) Richard Ottman et al. Molecular Cancer
- IRS2 Copy Number Gain, KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
- (2014) F. Huang et al. MOLECULAR CANCER THERAPEUTICS
- The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem Cells
- (2014) Roberta Malaguarnera et al. Frontiers in Endocrinology
- Insulin growth factor receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with metastatic adrenocortical carcinoma
- (2013) A Naing et al. BRITISH JOURNAL OF CANCER
- FOXC2 Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Breast Cancer
- (2013) B. G. Hollier et al. CANCER RESEARCH
- Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines
- (2013) Masanobu Tsubaki et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- A phase II study of cixutumumab (IMC-A12, NSC742460) in advanced hepatocellular carcinoma
- (2013) Ghassan K. Abou-Alfa et al. JOURNAL OF HEPATOLOGY
- Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial
- (2013) Gary K Schwartz et al. LANCET ONCOLOGY
- Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trial
- (2013) John FR Robertson et al. LANCET ONCOLOGY
- Anticancer IGF1R classes take more knocks
- (2013) Malini Guha NATURE REVIEWS DRUG DISCOVERY
- IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations
- (2013) Alejandro Vazquez-Martin et al. Scientific Reports
- Abstract 4836: Inhibition of PI3K/mTOR leads to adaptive resistance in extracellular matrix attached cancer cells
- (2012) Taru E. Muranen et al. CANCER RESEARCH
- Epithelial-Mesenchymal Transition Induced by TNF- Requires NF- B-Mediated Transcriptional Upregulation of Twist1
- (2012) C.-W. Li et al. CANCER RESEARCH
- TRAIL-activated EGFR by Cbl-b-regulated EGFR redistribution in lipid rafts antagonises TRAIL-induced apoptosis in gastric cancer cells
- (2012) Ling Xu et al. EUROPEAN JOURNAL OF CANCER
- Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma
- (2012) Juanjuan Shan et al. HEPATOLOGY
- Clinical development of insulin-like growth factor receptor—1 (IGF-1R) inhibitors: At the crossroad?
- (2012) Andrea Gombos et al. INVESTIGATIONAL NEW DRUGS
- TGFβ signalling in context
- (2012) Joan Massagué NATURE REVIEWS MOLECULAR CELL BIOLOGY
- MEMO1, a new IRS1-interacting protein, induces epithelial–mesenchymal transition in mammary epithelial cells
- (2012) A V Sorokin et al. ONCOGENE
- MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor
- (2012) X Zhao et al. ONCOGENE
- Molecular Basis of Signaling Specificity of Insulin and IGF Receptors: Neglected Corners and Recent Advances
- (2012) Kenneth Siddle Frontiers in Endocrinology
- A Phase I Pharmacokinetic and Pharmacodynamic Study of Dalotuzumab (MK-0646), an Anti-Insulin-like Growth Factor-1 Receptor Monoclonal Antibody, in Patients with Advanced Solid Tumors
- (2011) F. Atzori et al. CLINICAL CANCER RESEARCH
- Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer
- (2011) Elizabeth Buck et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- SNAIL Regulates Interleukin-8 Expression, Stem Cell–Like Activity, and Tumorigenicity of Human Colorectal Carcinoma Cells
- (2011) Wei–Lun Hwang et al. GASTROENTEROLOGY
- CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer
- (2011) G. Lorenzatti et al. JOURNAL OF CELL SCIENCE
- High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling
- (2011) Hind Medyouf et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma
- (2011) Yin-He Wang et al. JOURNAL OF SURGICAL ONCOLOGY
- Temporal and Spatial Cooperation of Snail1 and Twist1 during Epithelial-Mesenchymal Transition Predicts for Human Breast Cancer Recurrence
- (2011) D. D. Tran et al. MOLECULAR CANCER RESEARCH
- Epithelial-Mesenchymal Transition Predicts Sensitivity to the Dual IGF-1R/IR Inhibitor OSI-906 in Hepatocellular Carcinoma Cell Lines
- (2011) H. Zhao et al. MOLECULAR CANCER THERAPEUTICS
- Twist2 contributes to breast cancer progression by promoting an epithelial–mesenchymal transition and cancer stem-like cell self-renewal
- (2011) X Fang et al. ONCOGENE
- Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling
- (2011) C Garofalo et al. ONCOGENE
- Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways
- (2010) Jairam Vanamala et al. BMC CANCER
- Divergent effects of insulin-like growth factor-1 receptor expression on prognosis of estrogen receptor positive versus triple negative invasive ductal breast carcinoma
- (2010) Hermien Hartog et al. BREAST CANCER RESEARCH AND TREATMENT
- A Phase I Study of Weekly R1507, A Human Monoclonal Antibody Insulin-like Growth Factor-I Receptor Antagonist, in Patients with Advanced Solid Tumors
- (2010) R. Kurzrock et al. CLINICAL CANCER RESEARCH
- The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness
- (2010) Zhiwei Wang et al. CURRENT DRUG TARGETS
- Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: Roles in skeletal muscle growth and differentiation
- (2010) Cunming Duan et al. GENERAL AND COMPARATIVE ENDOCRINOLOGY
- Snail1 suppresses TGF- -induced apoptosis and is sufficient to trigger EMT in hepatocytes
- (2010) D. L. Franco et al. JOURNAL OF CELL SCIENCE
- Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer
- (2010) E. Buck et al. MOLECULAR CANCER THERAPEUTICS
- Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
- (2010) S Eliasz et al. ONCOGENE
- Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas
- (2010) J Braun et al. ONCOGENE
- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
- (2010) A Singh et al. ONCOGENE
- Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
- (2010) D. B. Ulanet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression
- (2009) Toru Mukohara et al. CANCER LETTERS
- Chemoresistant Colorectal Cancer Cells, the Cancer Stem Cell Phenotype, and Increased Sensitivity to Insulin-like Growth Factor-I Receptor Inhibition
- (2009) N. A. Dallas et al. CANCER RESEARCH
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- Inhibition of Insulin-Like Growth Factor 1 Receptor by CP-751,871 Radiosensitizes Non-Small Cell Lung Cancer Cells
- (2009) T. Iwasa et al. CLINICAL CANCER RESEARCH
- Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease
- (2009) Antonino Belfiore et al. ENDOCRINE REVIEWS
- The class I bHLH factors E2-2A and E2-2B regulate EMT
- (2009) V. R. Sobrado et al. JOURNAL OF CELL SCIENCE
- Biomarkers for epithelial-mesenchymal transitions
- (2009) Michael Zeisberg et al. JOURNAL OF CLINICAL INVESTIGATION
- The basics of epithelial-mesenchymal transition
- (2009) Raghu Kalluri et al. JOURNAL OF CLINICAL INVESTIGATION
- Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells
- (2009) Yin-He Wang et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer
- (2009) J. Zha et al. MOLECULAR CANCER THERAPEUTICS
- Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions
- (2009) A Gualberto et al. ONCOGENE
- Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
- (2009) Nawneet K. Kurrey et al. STEM CELLS
- Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors
- (2008) E. Buck et al. CANCER RESEARCH
- Insulin-like Growth Factor-I-Dependent Up-regulation of ZEB1 Drives Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells
- (2008) T. R. Graham et al. CANCER RESEARCH
- The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors
- (2008) F. Huang et al. CANCER RESEARCH
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Epithelial-Mesenchymal Transition and the Stem Cell Phenotype
- (2008) Derek C. Radisky et al. Cell Stem Cell
- IGF-1 Receptor Inhibitors in Clinical Trials—Early Lessons
- (2008) S. John Weroha et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- IGF-1 Mediates PTEN Suppression and Enhances Cell Invasion and Proliferation via Activation of the IGF-1/PI3K/Akt Signaling Pathway in Pancreatic Cancer Cells
- (2008) Jiachi Ma et al. JOURNAL OF SURGICAL RESEARCH
- Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials
- (2008) J. Rodon et al. MOLECULAR CANCER THERAPEUTICS
- HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924
- (2008) P. Haluska et al. MOLECULAR CANCER THERAPEUTICS
- Snail promotes Wnt target gene expression and interacts with β-catenin
- (2008) V Stemmer et al. ONCOGENE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started