Article
Biochemistry & Molecular Biology
Jessica Segales, Carlos Sanchez-Martin, Aleida Pujol-Morcillo, Marta Martin-Ruiz, Patricia de los Santos, Daniel Lobato-Alonso, Eduardo Oliver, Eduardo Rial
Summary: The role of UCP2 in energy metabolism and cell proliferation in lung adenocarcinoma cells was investigated. The results show that UCP2 silencing decreases basal respiration and cell proliferation, suggesting its involvement in metabolic adaptations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Qian Zhang, Mengyun Shi, Ruiling Zheng, Haoyi Han, Xin Zhang, Feng Lin
Summary: This study demonstrates that C1632 can inhibit the proliferation and migration of ovarian cancer cells by concurrently inhibiting the LIN28B/let-7/FAK signaling pathway and FAK phosphorylation, and it also exhibits a significant inhibitory effect on ovarian cancer xenograft tumors in mice. Therefore, C1632 is a promising onco-therapeutic agent for the treatment of ovarian cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Simon Ebert, Lan Zang, Noor Ismail, Michael Otabil, Adrian Frohlich, Virginia Egea, Susann Acs, Mikkel Hoeberg, Marie-Luise Berres, Christian Weber, Jose M. A. Moreira, Christian Ries, Juergen Bernhagen, Omar El Bounkari
Summary: TIMP-1 interacts with CD74 to regulate vascular inflammation and atherosclerosis. TIMP-1 binding to CD74 promotes monocyte migration and vascular smooth muscle cell proliferation, playing a crucial role in vascular inflammation and atherosclerosis.
Article
Oncology
Zhen Shen, Weiguo Song, Lili Qian, Jing Zhu, Yuebo Li, Min Li, Tianjiao Zhang, Weidong Zhao, Ying Zhou, Xingsheng Yang
Summary: Claudin 1 was found to inhibit cell proliferation and migration, and promote apoptosis in different human cervical cancer cell lines. In vivo experiments showed that overexpression of claudin 1 reduced tumor growth. The study suggests that claudin 1 may play an anti-tumor role in cervical squamous cell carcinoma.
Article
Cell Biology
Carsten Baltes, Divyendu Goud Thalla, Uli Kazmaier, Franziska Lautenschlaeger
Summary: Actin plays a crucial role in maintaining cell shape and generating forces. By stabilizing actin filaments with miuraenamide A, we observed a decrease in filament dynamics and an elongation of filament length, resulting in altered cell migration speed and nuclear position.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Gang Peng, Yi Liu, Chenxing Yang, Chenfu Shen
Summary: This study found that miR-25 is significantly upregulated in glioma and promotes the proliferation, migration, and invasion of glioma cells by directly targeting CADM2.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fangyuan Yu, Xinya Zhao, Mingtao Li, Min Meng
Summary: This study investigated the role of SLITRK6 in lung adenocarcinoma (LUAD) and found that it is significantly upregulated in LUAD tissues. Knockdown of SLITRK6 inhibited the proliferation and colony formation of LUAD cells both in vitro and in vivo. The mechanism involves the regulation of PI3K/AKT/mTOR signaling and the Warburg effect. Therefore, SLITRK6 may be a potential therapeutic target for LUAD.
Article
Cell Biology
Yongmeng Li, Yanfei Liu, Kai Jin, Rui Dong, Cun Gao, Libo Si, Zitong Feng, Huiying Zhang, Hui Tian
Summary: MTFR1 is upregulated in LUAD and associated with poor clinicopathologic features and prognosis. Overexpression of MTFR1 promotes proliferation, invasion, migration, glycolytic capacity, and inhibits apoptosis of LUAD cells. MTFR1 may exert its functions through the AMPK/mTOR signaling pathway and is targeted by miR-29c-3p. Targeting MTFR1 could be an effective therapeutic strategy for LUAD treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Biomaterials
Adrian A. Shimpi, Erik D. Williams, Lu Ling, Tigist Tamir, Forest M. White, Claudia Fischbach
Summary: This study investigates tumor cell migration on fibrotic ECM using a cell-derived matrix (CDM) model and phosphotyrosine phosphoproteomics. The results demonstrate that tumor cells cultured on CDMs migrate faster and in a more directional manner, which correlates with decreased cell spreading and increased cell elongation. The study also suggests that LYN may be differentially regulated and involved in regulating tumor cell migration on CDMs.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Huan Ma, Siyu Jiang, Yinan Yuan, Ji Li, Yizhuo Li, Yanping Lv, Tengjiao Du, Jingqian Guan, Xizi Jiang, Lei Tian, Qianqian Zheng, Lianhe Yang, Qingchang Li
Summary: RUNX1, a member of the RUNX family, is involved in the regulation of non-small cell lung cancer. It promotes cell proliferation and migration via the mTOR pathway and may serve as a potential therapeutic target for NSCLC.
Review
Biochemistry & Molecular Biology
Dina Johar, Ahmed O. Elmehrath, Rania M. Khalil, Mostafa H. Elberry, Samy Zaky, Samy A. Shalabi, Larry H. Bernstein
Summary: The study focuses on the significance of the Warburg effect and reverse Warburg effect in cancer development, as well as the dysregulation of related regulatory mechanisms and cellular metabolic pathways. By exploring cell communications and metabolic pathway shifts, potential new directions and targets for cancer pharmacotherapy are being highlighted.
Article
Multidisciplinary Sciences
Jianjiang Hu, Xiaowei Gong, Staffan Stromblad
Summary: Cells probe their microenvironment using membrane protrusion-retraction cycles. Spatial and temporal coordination between Rac1 and RhoA GTP-binding activities play critical roles in initiating and reinforcing protrusions and retractions. Rac1-GTP levels increase before protrusions, while RhoA-GTP levels increase before retractions. Rac1-GTP nadirs and peaks coincide with maximal edge velocity of local membrane protrusions and retractions, followed by declined edge velocity. The alteration of local Rac1-GTP precedes the alteration of traction force. Through optogenetic Rac1-GTP perturbations, we demonstrate the fundamental role of Rac1 in restricting the size and durability of protrusions and retractions, possibly through controlling traction forces.
Article
Multidisciplinary Sciences
Sayantanee Biswas, Michelle R. Emond, Kurtis P. Chenoweth, James D. Jontes
Summary: The study found that lesions in delta-protocadherins increase cell divisions of neural progenitors in the hindbrain due to mis-regulation of the Wnt/beta-catenin signaling pathway. Additionally, delta-protocadherins can form a complex with the Wnt receptor Ryk, which is required for the increased proliferation in protocadherin mutants. This suggests that delta-protocadherins are novel regulators of Wnt/beta-catenin signaling in the development of neural circuits.
Article
Biochemistry & Molecular Biology
Bin Xiong, Zehui Xie, Feixue Song, Huiling Chen, Xiaojuan Wang, Zhengxu Jin, Tiyun Han, Yi Li, Dekui Zhang
Summary: DDR1a plays a crucial role in colorectal cancer by promoting cell proliferation, regulating mitochondrial function and extracellular acidification, and influencing metabolic reprogramming to maintain intracellular environment homeostasis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Oncology
Sha Song, Ji Zhang, Qi Su, Weimin Zhang, Yunxin Jiang, Gao Fan, Chen'ao Qian, Bingzong Li, Wenzhuo Zhuang
Summary: The study revealed differential expression of ITGA6 between multiple myeloma and secondary plasma cell leukemia patients, with low ITGA6 expression associated with increased myeloma cell invasion and significant impact on patient prognosis.
BRITISH JOURNAL OF CANCER
(2021)