TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells

Erratum: MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer

(2016) Y Zhang et al.   Cell Death & Disease

Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon

(2015) Joel Pekow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

MicroRNA-520g Confers Drug Resistance by Regulating p21 Expression in Colorectal Cancer

(2015) Yang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST

(2015) Kassondra Meyer et al.   MOLECULAR AND CELLULAR BIOLOGY

High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer

(2015) L. Flanagan et al.   Radiation Oncology

Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer

(2014) Ekta Agarwal et al.   BMC CANCER

MicroRNA-192 suppresses liver metastasis of colon cancer

(2013) L Geng et al.   ONCOGENE

TGF-Beta Suppresses VEGFA-Mediated Angiogenesis in Colon Cancer Metastasis

(2013) Liying Geng et al.   PLoS One

Down-Regulation of miR-126 Is Associated with Colorectal Cancer Cells Proliferation, Migration and Invasion by Targeting IRS-1 via the AKT and ERK1/2 Signaling Pathways

(2013) Yu Zhou et al.   PLoS One

Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells

(2012) Neka A K Simms et al.   BMC CANCER

The Insulin Receptor Substrate 1 (Irs1) in Intestinal Epithelial Differentiation and in Colorectal Cancer

(2012) Diana L. Esposito et al.   PLoS One

Prognostic significance of transforming growth factor beta (TGF-β) signaling axis molecules and E-cadherin in colorectal cancer

(2012) Pavlos Lampropoulos et al.   TUMOR BIOLOGY

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1

(2011) Hendrik Ungefroren et al.   Molecular Cancer

Identification of a Novel TGFβ/PKA Signaling Transduceome in Mediating Control of Cell Survival and Metastasis in Colon Cancer

(2011) Sanjib Chowdhury et al.   PLoS One

Targeting the Insulin-like Growth Factor Receptor-1R Pathway for Cancer Therapy

(2010) J. Zha et al.   CLINICAL CANCER RESEARCH

Expression and function of the insulin receptor substrate proteins in cancer

(2009) Katerina Mardilovich et al.   Cell Communication and Signaling

Increased expression of both insulin receptor substrates 1 and 2 confers increased sensitivity to IGF-1 stimulated cell migration

(2009) Gail E de Blaquière et al.   ENDOCRINE-RELATED CANCER

Mechanism of growth inhibition by MicroRNA 145: The role of the IGF-I receptor signaling pathway

(2009) Gaspare La Rocca et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Expression of X-linked inhibitor of apoptosis protein in human colorectal cancer and its correlation with prognosis

(2009) Xiang Guoan et al.   JOURNAL OF SURGICAL ONCOLOGY

Heterogeneity of Receptor Function in Colon Carcinoma Cells Determined by Cross-talk between Type I Insulin-like Growth Factor Receptor and Epidermal Growth Factor Receptor

(2008) Y. P. Hu et al.   CANCER RESEARCH

Transforming Growth Factor   Induces Apoptosis through Repressing the Phosphoinositide 3-Kinase/AKT/Survivin Pathway in Colon Cancer Cells

(2008) J. Wang et al.   CANCER RESEARCH

The insulin receptor substrate-1: A biomarker for cancer?

(2008) Renato Baserga   EXPERIMENTAL CELL RESEARCH

Insulin Receptor Substrates (IRSs) and Breast Tumorigenesis

(2008) Bonita Tak-Yee Chan et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Insulin Receptor Substrate-1 Deficiency Promotes Apoptosis in the Putative Intestinal Crypt Stem Cell Region, Limits Apcmin/+Tumors, and Regulates Sox9

(2007) Nicole M. Ramocki et al.   ENDOCRINOLOGY