Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases

Sphingosine 1-Phosphate in Renal Diseases

(2013) Alexander Koch et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The danger control concept in kidney disease: mesangial cells

(2013) Adriana Migliorini et al.   JOURNAL OF NEPHROLOGY

Inhibition of Sphingosine Kinase-2 in a Murine Model of Lupus Nephritis

(2013) Ashley J. Snider et al.   PLoS One

US Renal Data System 2012 Annual Data Report

(2012) Allan J. Collins et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases

(2012) Stephanie Schwalm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells

(2012) A Koch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease

(2012) Thomas A. Natoli et al.   HUMAN MOLECULAR GENETICS

Low-Density Lipoprotein Induced Expression of Connective Tissue Growth Factor via Transactivation of Sphingosine 1-Phosphate Receptors in Mesangial Cells

(2012) Hesham M. El-Shewy et al.   MOLECULAR ENDOCRINOLOGY

Membranoproliferative Glomerulonephritis — A New Look at an Old Entity

(2012) Sanjeev Sethi et al.   NEW ENGLAND JOURNAL OF MEDICINE

TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720

(2011) J.F. Pedregosa et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of Sphingosine 1-Phosphate Receptor 2 Protects against Renal Ischemia-Reperfusion Injury

(2011) S. Won Park et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sphingosine kinase 1 protects against renal ischemia–reperfusion injury in mice by sphingosine-1-phosphate1 receptor activation

(2011) Sang Won Park et al.   KIDNEY INTERNATIONAL

Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes

(2011) Alaa S. Awad et al.   KIDNEY INTERNATIONAL

The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis

(2011) Manshu Sui et al.   MOLECULAR BIOLOGY REPORTS

Sphingosine Kinase-1 Pathway Mediates High Glucose-Induced Fibronectin Expression in Glomerular Mesangial Cells

(2011) Tian Lan et al.   MOLECULAR ENDOCRINOLOGY

FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study

(2011) Andries J. Hoitsma et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A Prokaryotic S1P Lyase Degrades Extracellular S1P In Vitro and In Vivo: Implication for Treating Hyperproliferative Disorders

(2011) Andrea Huwiler et al.   PLoS One

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation

(2010) Ashley J. Snider et al.   BIOCHIMIE

Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration

(2010) Roger A. Sabbadini   BRITISH JOURNAL OF PHARMACOLOGY

Linking cell structure to gene regulation: Signaling events and expression controls on the model genes PAI-1 and CTGF

(2010) Rohan Samarakoon et al.   CELLULAR SIGNALLING

Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P3 Axis

(2010) Francesca Cencetti et al.   MOLECULAR BIOLOGY OF THE CELL

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy

(2009) Toshiyuki Imasawa et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

The Mesangial Cell Revisited: No Cell Is an Island

(2009) D. Schlondorff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression

(2009) Shuyu Ren et al.   KIDNEY INTERNATIONAL

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets

(2008) Andrea Huwiler et al.   BIOCHEMICAL PHARMACOLOGY

Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner

(2008) Lotte P. Hofmann et al.   BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease

(2008) S.-K. Jo et al.   KIDNEY INTERNATIONAL

Divergent roles of sphingosine kinases in kidney ischemia–reperfusion injury

(2008) Sang-Kyung Jo et al.   KIDNEY INTERNATIONAL