The DNA damage response pathway in normal hematopoiesis and malignancies

The cell cycle checkpoint inhibitors in the treatment of leukemias

(2017) A. Ghelli Luserna di Rora’ et al.   Journal of Hematology & Oncology

Increase of DNA damage and alteration of the DNA damage response in myelodysplastic syndromes and acute myeloid leukemias

(2017) Henning D. Popp et al.   LEUKEMIA RESEARCH

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

(2017) Parker L. Sulkowski et al.   Science Translational Medicine

Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function

(2017) Victoria E. Mgbemena et al.   Cell Reports

BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation

(2017) Mayu Isono et al.   Cell Reports

Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells

(2017) Jun Ma et al.   Scientific Reports

Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

(2016) Stephanie A. Yazinski et al.   Annual Review of Genetics

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2

(2016) Satoshi Inoue et al.   CANCER CELL

The DNA damage-induced cell death response: a roadmap to kill cancer cells

(2016) Sonja Matt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PARP-inhibitor-induced synthetic lethality for acute myeloid leukemia treatment

(2016) Lu Zhao et al.   EXPERIMENTAL HEMATOLOGY

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia

(2016) Mark A. Gregory et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHK1 as a therapeutic target to bypass chemoresistance in AML

(2016) Laure David et al.   Science Signaling

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models ofMLL-rearranged AML

(2016) Isabel Morgado-Palacin et al.   Science Signaling

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

(2016) Jessica S. Brown et al.   Cancer Discovery

Prexasertib, a Chk1/Chk2 inhibitor, increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia

(2016) Andrea Ghelli Luserna Di Rorà et al.   Oncotarget

CHK1 as a therapeutic target to bypass chemoresistance in AML

(2016) Laure David et al.   Science Signaling

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models ofMLL-rearranged AML

(2016) Isabel Morgado-Palacin et al.   Science Signaling

The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy

(2015) Michael Goldstein et al.   Annual Review of Medicine

BRCA1, PARP1 and γH2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib

(2015) Isabella Faraoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells

(2015) M. Kwok et al.   BLOOD

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

(2015) Simona Colla et al.   CANCER CELL

DNA Damage: A Sensible Mediator of the Differentiation Decision in Hematopoietic Stem Cells and in Leukemia

(2015) Cary Weiss et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia

(2015) Ilaria Iacobucci et al.   Journal of Hematology & Oncology

Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway

(2015) Marwan Kwok et al.   LANCET

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

PARP1 expression, activity and ex vivo sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia

(2015) Ashleigh Herriott et al.   Oncotarget

Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma

(2015) Enrico Derenzini et al.   Oncotarget

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

(2014) Margarida A. Santos et al.   NATURE

CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress

(2014) L M Sarmento et al.   ONCOGENE

CHK2 kinase in the DNA damage response and beyond

(2014) L. Zannini et al.   Journal of Molecular Cell Biology

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

DNA repair genes are selectively mutated in diffuse large B cell lymphomas

(2013) Noel FCC de Miranda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin and the genome integrity network

(2012) Manolis Papamichos-Chronakis et al.   NATURE REVIEWS GENETICS

The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo

(2010) V. J. Weston et al.   BLOOD

Mechanism of p53 stabilization by ATM after DNA damage

(2010) Qian Cheng et al.   CELL CYCLE

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

(2010) Aaron A. Goodarzi et al.   DNA REPAIR

Assembly and function of DNA double-strand break repair foci in mammalian cells

(2010) Simon Bekker-Jensen et al.   DNA REPAIR

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

(2010) Patryk Moskwa et al.   MOLECULAR CELL