In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia

The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia

(2012) Anthony V. Moorman   BLOOD REVIEWS

Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy

(2012) M. Maugeri-Saccà et al.   CANCER TREATMENT REVIEWS

Phase I and Pharmacologic Trial of Cytosine Arabinoside with the Selective Checkpoint 1 Inhibitor Sch 900776 in Refractory Acute Leukemias

(2012) J. E. Karp et al.   CLINICAL CANCER RESEARCH

The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of p53-Mutated Multiple Myeloma Cells

(2012) H. J. Landau et al.   MOLECULAR CANCER THERAPEUTICS

Chromatin dynamics and the repair of DNA double strand breaks

(2011) Ye Xu et al.   CELL CYCLE

Current Therapeutic Strategies in Adult Acute Lymphoblastic Leukemia

(2011) Adele K. Fielding   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

The G2 DNA damage checkpoint: Could this ancient regulator be the Achilles heel of cancer?

(2010) Karen Kuntz et al.   CANCER BIOLOGY & THERAPY

Tumor Suppressor CHK2: Regulator of DNA Damage Response and Mediator of Chromosomal Stability

(2010) A. Stolz et al.   CLINICAL CANCER RESEARCH

PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts

(2009) C. Zhang et al.   CLINICAL CANCER RESEARCH

Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia

(2009) V Conter et al.   LEUKEMIA

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

(2009) L. A. Parsels et al.   MOLECULAR CANCER THERAPEUTICS

Cleavage-mediated Activation of Chk1 during Apoptosis

(2008) Kenkyo Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute lymphoblastic leukaemia

(2008) Ching-Hon Pui et al.   LANCET

Bone-marrow relapse in paediatric acute lymphoblastic leukaemia

(2008) L Charles Bailey et al.   LANCET ONCOLOGY

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1

(2008) A. Blasina et al.   MOLECULAR CANCER THERAPEUTICS

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

(2008) S. D. Zabludoff et al.   MOLECULAR CANCER THERAPEUTICS