First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases

Psoriasis

(2016) Stephen M. Schleicher   Clinics in Podiatric Medicine and Surgery

Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond

(2014) Christopher S. Garris et al.   IMMUNOLOGY

The Proline-Rich Sequence of CD3  as an Amplifier of Low-Avidity TCR Signaling

(2014) P. Tailor et al.   JOURNAL OF IMMUNOLOGY

Relevance of Nck-CD3  Interaction for T Cell Activation In Vivo

(2014) A. Borroto et al.   JOURNAL OF IMMUNOLOGY

Vaccine-Induced Protection against Orthopoxvirus Infection Is Mediated through the Combined Functions of CD4 T Cell-Dependent Antibody and CD8 T Cell Responses

(2014) Geeta Chaudhri et al.   JOURNAL OF VIROLOGY

Optimal T-cell receptor affinity for inducing autoimmunity

(2014) Sabrina Koehli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational changes in the T cell receptor differentially determine T cell subset development in mice

(2014) R. Blanco et al.   Science Signaling

Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection

(2013) Noah J. Tubo et al.   CELL

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

(2013) Barry Flutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interferon-Gamma Producing Regulatory T Cells as a Diagnostic and Therapeutic Tool in Organ Transplantation

(2013) Volker Daniel et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells

(2013) Angelo Castello et al.   NATURE IMMUNOLOGY

New treatments and treatment goals for patients with relapsing-remitting multiple sclerosis

(2012) Edward J. Fox et al.   CURRENT OPINION IN NEUROLOGY

Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection

(2012) Sarah Enouz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development

(2012) A. Borroto et al.   JOURNAL OF IMMUNOLOGY

How the TCR balances sensitivity and specificity for the recognition of self and pathogens

(2012) Gerald P Morris et al.   NATURE IMMUNOLOGY

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

(2012) Anna M Bulek et al.   NATURE IMMUNOLOGY

Treating Human Autoimmunity: Current Practice and Future Prospects

(2012) M. D. Rosenblum et al.   Science Translational Medicine

Relapse of Experimental Autoimmune Encephalomyelitis after Discontinuation of FTY720 (Fingolimod) Treatment, but Not after Combination of FTY720 and Pathogenic Autoantigen

(2011) Yuya Yoshida et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The protein interaction network mediated by human SH3 domains

(2011) Martina Carducci et al.   BIOTECHNOLOGY ADVANCES

Molecular mechanisms of T-cell tolerance

(2011) Roza I. Nurieva et al.   IMMUNOLOGICAL REVIEWS

VSDMIP 1.5: an automated structure- and ligand-based virtual screening platform with a PyMOL graphical user interface

(2011) Álvaro Cortés Cabrera et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

(2010) Byron B Au-Yeung et al.   NATURE IMMUNOLOGY

Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire

(2010) E. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal models of multiple sclerosis—Potentials and limitations

(2010) Eilhard Mix et al.   PROGRESS IN NEUROBIOLOGY

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

Chemotherapeutics in the treatment of multiple sclerosis

(2010) Bernd C. Kieseier et al.   Therapeutic Advances in Neurological Disorders

Monoclonal antibody-induced cytokine-release syndrome

(2009) Peter J Bugelski et al.   Expert Review of Clinical Immunology

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

Noninvasive Quantitative Tomography of the Therapeutic Response to Dexamethasone in Ovalbumin-Induced Murine Asthma

(2009) H. Korideck et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Essential function for the GTPase TC21 in homeostatic antigen receptor signaling

(2009) Pilar Delgado et al.   NATURE IMMUNOLOGY

Checkpoints in lymphocyte development and autoimmune disease

(2009) Harald von Boehmer et al.   NATURE IMMUNOLOGY

How Diverse--CD4 Effector T Cells and their Functions

(2009) Y. Y. Wan et al.   Journal of Molecular Cell Biology

Interaction between the N-terminal SH3 domain of Nckα and CD3ɛ-derived peptides: Non-canonical and canonical recognition motifs

(2008) Clara M. Santiveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

VSDMIP: virtual screening data management on an integrated platform

(2008) Rubén Gil-Redondo et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Structural Basis of PxxDY Motif Recognition in SH3 Binding

(2008) Olli Aitio et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor Activity

(2008) Koh Takeuchi et al.   JOURNAL OF MOLECULAR BIOLOGY

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

(2008) Michelle M. A. Fernando et al.   PLoS Genetics