Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity
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Title
Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity
Authors
Keywords
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Journal
PLoS Computational Biology
Volume 9, Issue 3, Pages e1003004
Publisher
Public Library of Science (PLoS)
Online
2013-03-29
DOI
10.1371/journal.pcbi.1003004
References
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Related references
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- Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation
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- IGSF4 is a novel TCR ζ-chain–interacting protein that enhances TCR-mediated signaling
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- Nonessential Sites Improve Phosphorylation Switch
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- A Combination of Multisite Phosphorylation and Substrate Sequestration Produces Switchlike Responses
- (2010) Xinfeng Liu et al. BIOPHYSICAL JOURNAL
- Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction
- (2010) Konstantina Nika et al. IMMUNITY
- T Cell Activation
- (2009) Jennifer E. Smith-Garvin et al. Annual Review of Immunology
- Aggregation of Membrane Proteins by Cytosolic Cross-Linkers: Theory and Simulation of the LAT-Grb2-SOS1 System
- (2009) Ambarish Nag et al. BIOPHYSICAL JOURNAL
- Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells
- (2009) Jayajit Das et al. CELL
- The promise and potential pitfalls of chimeric antigen receptors
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- Multisite protein phosphorylation - from molecular mechanisms to kinetic models
- (2009) Carlos Salazar et al. FEBS Journal
- Organization of proximal signal initiation at the TCR:CD3 complex
- (2009) Clifford S. Guy et al. IMMUNOLOGICAL REVIEWS
- Unlimited multistability in multisite phosphorylation systems
- (2009) Matthew Thomson et al. NATURE
- Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif
- (2008) Chenqi Xu et al. CELL
- Computational Models of Tandem Src Homology 2 Domain Interactions and Application to Phosphoinositide 3-Kinase
- (2008) Dipak Barua et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Stochastic effects and bistability in T cell receptor signaling
- (2008) Tomasz Lipniacki et al. JOURNAL OF THEORETICAL BIOLOGY
- Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity
- (2008) Jeff Holst et al. NATURE IMMUNOLOGY
- Src Family Kinases and Receptors: Analysis of Three Activation Mechanisms by Dynamic Systems Modeling
- (2007) Hendrik Fuß et al. BIOPHYSICAL JOURNAL
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