Translational Research in the Nonhuman Primate Model of Tuberculosis

The Promise of Molecular Imaging in the Study and Treatment of Infectious Diseases

(2017) Sanjay K. Jain   MOLECULAR IMAGING AND BIOLOGY

Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

(2016) Russell D. Berg et al.   CELL

Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques withMycobacterium tuberculosisInfection

(2016) Hannah P. Gideon et al.   JOURNAL OF IMMUNOLOGY

Adaptation ofMycobacterium tuberculosisto Impaired Host Immunity in HIV-Infected Patients

(2016) Nicholas D. Walter et al.   JOURNAL OF INFECTIOUS DISEASES

CD4+T-cell–independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection

(2016) Taylor W. Foreman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations

(2016) S. Sharpe et al.   TUBERCULOSIS

Combining biomedical preventions for HIV: Vaccines with pre-exposure prophylaxis, microbicides or other HIV preventions

(2016) Janet M. McNicholl   Human Vaccines & Immunotherapeutics

Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis

(2016) Rolf Billeskov et al.   PLoS One

LAG3 Expression in Active Mycobacterium tuberculosis Infections

(2015) Bonnie L. Phillips et al.   AMERICAN JOURNAL OF PATHOLOGY

A Novel Nonhuman Primate Model of Cigarette Smoke–Induced Airway Disease

(2015) Francesca Polverino et al.   AMERICAN JOURNAL OF PATHOLOGY

The DosR Regulon Modulates Adaptive Immunity and Is Essential forMycobacterium tuberculosisPersistence

(2015) Smriti Mehra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evaluation of the Immunogenicity of Mycobacterium bovis BCG Delivered by Aerosol to the Lungs of Macaques

(2015) A. D. White et al.   Clinical and Vaccine Immunology

Immunology studies in non-human primate models of tuberculosis

(2015) JoAnne L. Flynn et al.   IMMUNOLOGICAL REVIEWS

Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies

(2015) Igor Kramnik et al.   Seminars in Immunopathology

The TB-specific CD4 + T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans

(2015) Bianca R. Mothé et al.   TUBERCULOSIS

First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults

(2015) Angelique Kany Kany Luabeya et al.   VACCINE

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis

(2015) Deepak Kaushal et al.   Nature Communications

Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial

(2015) François Spertini et al.   Lancet Respiratory Medicine

Cigarette Smoking Impairs Human Pulmonary Immunity toMycobacterium tuberculosis

(2014) Seónadh M. O’Leary et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early Changes by 18Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

(2014) M. T. Coleman et al.   INFECTION AND IMMUNITY

Aerosol Vaccination with AERAS-402 Elicits Robust Cellular Immune Responses in the Lungs of Rhesus Macaques but Fails To Protect against High-DoseMycobacterium tuberculosisChallenge

(2014) Patricia A. Darrah et al.   JOURNAL OF IMMUNOLOGY

Imaging Enterobacteriaceae infection in vivo with 18F-fluorodeoxysorbitol positron emission tomography

(2014) E. A. Weinstein et al.   Science Translational Medicine

PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis

(2014) M. T. Coleman et al.   Science Translational Medicine

Metformin as adjunct antituberculosis therapy

(2014) A. Singhal et al.   Science Translational Medicine

A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine

(2014) David A Hokey et al.   Human Vaccines & Immunotherapeutics

S100A8/A9 Proteins Mediate Neutrophilic Inflammation and Lung Pathology during Tuberculosis

(2013) Radha Gopal et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens

(2013) Philana Ling Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

(2013) Yanjia J. Zhang et al.   CELL

Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species

(2013) J Su et al.   CELL DEATH AND DIFFERENTIATION

Feast or famine: the host-pathogen battle over amino acids

(2013) Yanjia J. Zhang et al.   CELLULAR MICROBIOLOGY

Differential Virulence and Disease Progression following Mycobacterium tuberculosis Complex Infection of the Common Marmoset (Callithrix jacchus)

(2013) Laura E. Via et al.   INFECTION AND IMMUNITY

An Unbiased Genome-Wide Mycobacterium tuberculosis Gene Expression Approach To Discover Antigens Targeted by Human T Cells Expressed during Pulmonary Infection

(2013) S. Commandeur et al.   JOURNAL OF IMMUNOLOGY

Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials

(2013) Ainhoa Arbues et al.   VACCINE

18F-FDG PET/CT in tuberculosis: an early non-invasive marker of therapeutic response

(2012) V. Martinez et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Therapeutic Immunization against Mycobacterium tuberculosis Is an Effective Adjunct to Antibiotic Treatment

(2012) Rhea N. Coler et al.   JOURNAL OF INFECTIOUS DISEASES

Granuloma Correlates of Protection Against Tuberculosis and Mechanisms of Immune Modulation by Mycobacterium tuberculosis

(2012) Smriti Mehra et al.   JOURNAL OF INFECTIOUS DISEASES

The Mycobacterium tuberculosis Stress Response Factor SigH Is Required for Bacterial Burden as Well as Immunopathology in Primate Lungs

(2012) Smriti Mehra et al.   JOURNAL OF INFECTIOUS DISEASES

The non-human primate model of tuberculosis

(2012) D. Kaushal et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Meeting report: The international conference on human immunity to tuberculosis

(2012) Joel D. Ernst et al.   TUBERCULOSIS

Nonhuman Primate Models for HIV Cure Research

(2012) Cristian Apetrei et al.   PLoS Pathogens

The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection

(2011) Philana Ling Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Simian Immunodeficiency Virus-Induced Changes in T Cell Cytokine Responses in Cynomolgus Macaques with Latent Mycobacterium tuberculosis Infection Are Associated with Timing of Reactivation

(2011) J. T. Mattila et al.   JOURNAL OF IMMUNOLOGY

Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus

(2011) Smriti Mehra et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

(2010) Ashley T. Haase   Annual Review of Medicine

Establishment of an Aerosol Challenge Model of Tuberculosis in Rhesus Macaques and an Evaluation of Endpoints for Vaccine Testing

(2010) S. A. Sharpe et al.   Clinical and Vaccine Immunology

Genetic Requirements for the Survival of Tubercle Bacilli in Primates

(2010) Noton K. Dutta et al.   JOURNAL OF INFECTIOUS DISEASES

Reactivation of Latent Tuberculosis in Cynomolgus Macaques Infected with SIV Is Associated with Early Peripheral T Cell Depletion and Not Virus Load

(2010) Collin R. Diedrich et al.   PLoS One

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

(2009) P. L. Lin et al.   INFECTION AND IMMUNITY

MVA.85A Boosting of BCG and an Attenuated, phoP Deficient M. tuberculosis Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques

(2009) Frank A. W. Verreck et al.   PLoS One

Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys

(2009) S. G. Reed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis

(2009) S.A. Sharpe et al.   TUBERCULOSIS

Alcohol use as a risk factor for tuberculosis – a systematic review

(2008) Knut Lönnroth et al.   BMC PUBLIC HEALTH

The Enduring Hypoxic Response of Mycobacterium tuberculosis

(2008) Tige R. Rustad et al.   PLoS One