Immunology studies in non-human primate models of tuberculosis

Characterization of a Novel Necrotic Granuloma Model of Latent Tuberculosis Infection and Reactivation in Mice

(2014) Noton K. Dutta et al.   AMERICAN JOURNAL OF PATHOLOGY

Clonotype-specific avidity influences the dynamics and hierarchy of virus-specific regulatory and effector CD4+T-cell responses

(2014) Jie Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Early Changes by 18Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

(2014) M. T. Coleman et al.   INFECTION AND IMMUNITY

Macrophage Polarization in Bacterial Infections

(2014) M. Benoit et al.   JOURNAL OF IMMUNOLOGY

Graded Levels of IRF4 Regulate CD8+ T Cell Differentiation and Expansion, but Not Attrition, in Response to Acute Virus Infection

(2014) R. Nayar et al.   JOURNAL OF IMMUNOLOGY

CD4+ T Cells Contain Early Extrapulmonary Tuberculosis (TB) Dissemination and Rapid TB Progression and Sustain Multieffector Functions of CD8+ T and CD3- Lymphocytes: Mechanisms of CD4+ T Cell Immunity

(2014) S. Yao et al.   JOURNAL OF IMMUNOLOGY

Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas

(2014) M. A. Duque-Correa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Immune Response in Tuberculosis

(2013) Anne O'Garra et al.   Annual Review of Immunology

Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens

(2013) Philana Ling Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms

(2013) J. T. Mattila et al.   JOURNAL OF IMMUNOLOGY

Tuberculosis biomarkers discovery: developments, needs, and challenges

(2013) Robert S Wallis et al.   LANCET INFECTIOUS DISEASES

Is tuberculosis a lymphatic disease with a pulmonary portal?

(2013) Marcel A Behr et al.   LANCET INFECTIOUS DISEASES

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

(2013) Philana Ling Lin et al.   NATURE MEDICINE

A Humanized Mouse Model of Tuberculosis

(2013) Veronica E. Calderon et al.   PLoS One

Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG

(2013) Michele Tameris et al.   TUBERCULOSIS

A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data

(2013) Helen McShane et al.   TUBERCULOSIS

Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials

(2013) Ainhoa Arbues et al.   VACCINE

Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming

(2013) Miriam Samstein et al.   eLife

CD4 T Cell Depletion Exacerbates Acute Mycobacterium tuberculosis While Reactivation of Latent Infection Is Dependent on Severity of Tissue Depletion in Cynomolgus Macaques

(2012) Philana Ling Lin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Activated B Cells in the Granulomas of Nonhuman Primates Infected with Mycobacterium tuberculosis

(2012) Jia Yao Phuah et al.   AMERICAN JOURNAL OF PATHOLOGY

Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed from Infected Macrophages

(2012) Chao-Tsung Yang et al.   Cell Host & Microbe

The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?

(2012) Mayra Silva Miranda et al.   Clinical & Developmental Immunology

A Recombinant Attenuated Mycobacterium tuberculosis Vaccine Strain Is Safe in Immunosuppressed Simian Immunodeficiency Virus-Infected Infant Macaques

(2012) Kara Jensen et al.   Clinical and Vaccine Immunology

Arginase-1 expression in granulomas of tuberculosis patients: Figure 1

(2012) Ana P. Pessanha et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Local Immune Responses in Human Tuberculosis: Learning From the Site of Infection

(2012) Susanna Brighenti et al.   JOURNAL OF INFECTIOUS DISEASES

Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques

(2012) P. L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1/Mycobacterium tuberculosisCoinfection Immunology: How Does HIV-1 Exacerbate Tuberculosis?

(2011) Collin R. Diedrich et al.   INFECTION AND IMMUNITY

The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection

(2011) Philana Ling Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Simian Immunodeficiency Virus-Induced Changes in T Cell Cytokine Responses in Cynomolgus Macaques with Latent Mycobacterium tuberculosis Infection Are Associated with Timing of Reactivation

(2011) J. T. Mattila et al.   JOURNAL OF IMMUNOLOGY

Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus

(2011) Smriti Mehra et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Generation of HIV Latency in Humanized BLT Mice

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Macrophages and control of granulomatous inflammation in tuberculosis

(2011) J L Flynn et al.   Mucosal Immunology

The role of IL-10 in immune regulation during M. tuberculosis infection

(2011) P S Redford et al.   Mucosal Immunology

Tuberculosis vaccines: beyond bacille Calmette-Guerin

(2011) H. McShane   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Tuberculosis Immunity: Opportunities from Studies with Cattle

(2010) W. Ray Waters et al.   Clinical & Developmental Immunology

Time interval to conversion of interferon-  release assay after exposure to tuberculosis

(2010) S. W. Lee et al.   EUROPEAN RESPIRATORY JOURNAL

CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1-Mediated Inhibition

(2010) D. L. Barber et al.   JOURNAL OF IMMUNOLOGY

CD4+Regulatory T Cells in a Cynomolgus Macaque Model ofMycobacterium tuberculosisInfection

(2010) Angela M. Green et al.   JOURNAL OF INFECTIOUS DISEASES

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Reactivation of Latent Tuberculosis in Cynomolgus Macaques Infected with SIV Is Associated with Early Peripheral T Cell Depletion and Not Virus Load

(2010) Collin R. Diedrich et al.   PLoS One

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

(2010) E. Lazar-Molnar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-17 in protective immunity to intracellular pathogens

(2010) Shabaana A. Khader et al.   Virulence

Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates

(2009) Adrian F Gombart et al.   BMC GENOMICS

Arginase: an emerging key player in the mammalian immune system

(2009) Markus Munder   BRITISH JOURNAL OF PHARMACOLOGY

Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB

(2009) Seok-Yong Eum et al.   CHEST

The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis

(2009) Andrea M. Cooper et al.   IMMUNOLOGICAL REVIEWS

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

(2009) P. L. Lin et al.   INFECTION AND IMMUNITY

Cytotoxicity and Secretion of Gamma Interferon Are Carried Out by Distinct CD8 T Cells during Mycobacterium tuberculosis Infection

(2009) T. Einarsdottir et al.   INFECTION AND IMMUNITY

A Systemic Neutrophil Response Precedes Robust CD8+ T-Cell Activation during Natural Respiratory Syncytial Virus Infection in Infants

(2009) M. V. Lukens et al.   JOURNAL OF VIROLOGY

Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis

(2009) S.A. Sharpe et al.   TUBERCULOSIS

Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice

(2009) Jincun Zhao et al.   PLoS Pathogens

A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis

(2009) Crystal Y. Chen et al.   PLoS Pathogens

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Pulmonary Tuberculosis: Up-to-Date Imaging and Management

(2008) Yeon Joo Jeong et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes

(2008) W. W. Reiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA