Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy

Decreased Motor Neuron Support by SMA Astrocytes due to Diminished MCP1 Secretion

(2017) Jasmin E. Martin et al.   JOURNAL OF NEUROSCIENCE

Gene therapy for Parkinson's disease: Disease modification by GDNF family of ligands

(2017) Deniz Kirik et al.   NEUROBIOLOGY OF DISEASE

Cell-type-specific miR-431 dysregulation in a motor neuron model of spinal muscular atrophy

(2016) Mary H. Wertz et al.   HUMAN MOLECULAR GENETICS

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons

(2016) Claudia Fallini et al.   JOURNAL OF NEUROSCIENCE

Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy

(2016) Erkan Y Osman et al.   MOLECULAR THERAPY

An Integrative Transcriptomic Analysis for Identifying Novel Target Genes Corresponding to Severity Spectrum in Spinal Muscular Atrophy

(2016) Chung-Wei Yang et al.   PLoS One

SMN deficiency does not induce oxidative stress in SMA iPSC-derived astrocytes or motor neurons

(2015) Teresa N. Patitucci et al.   HUMAN MOLECULAR GENETICS

Astrocytes influence the severity of spinal muscular atrophy

(2015) Hansjörg Rindt et al.   HUMAN MOLECULAR GENETICS

Notch Signaling Regulates Motor Neuron Differentiation of Human Embryonic Stem Cells

(2015) Etti Ben-Shushan et al.   STEM CELLS

MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration

(2015) Akshay Bhinge et al.   STEM CELLS

Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker

(2015) Zhihui Yang et al.   TRENDS IN NEUROSCIENCES

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

(2015) Anmol Kumar et al.   PLoS Genetics

Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2

(2015) Susu Mao et al.   Protein & Cell

Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson’s Disease-Related LRRK2 G2019S Mutation

(2015) Andrew J. Schwab et al.   Stem Cell Reports

Defining the therapeutic window in a severe animal model of spinal muscular atrophy

(2014) K. L. Robbins et al.   HUMAN MOLECULAR GENETICS

Mechanisms Involved in Spinal Cord Central Synapse Loss in a Mouse Model of Spinal Muscular Atrophy

(2014) Olga Tarabal et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Survival of motor neuron protein downregulates miR-9 expression in patients with spinal muscular atrophy

(2014) Li-Ting Wang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Circulating miRNAs as Biomarkers for Neurodegenerative Disorders

(2014) Margherita Grasso et al.   MOLECULES

Transcriptome Profiling of Spinal Muscular Atrophy Motor Neurons Derived from Mouse Embryonic Stem Cells

(2014) Miho Maeda et al.   PLoS One

Proteomic analysis of mouse astrocytes and their secretome by a combination of FASP and StageTip-based, high pH, reversed-phase fractionation

(2014) Dohyun Han et al.   PROTEOMICS

SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

(2014) N. A. Naryshkin et al.   SCIENCE

Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia

(2013) Yi-Bing Ouyang et al.   GLIA

Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production

(2013) Jered V. McGivern et al.   GLIA

Notch Signaling Pathway Is Activated in Motoneurons of Spinal Muscular Atrophy

(2013) Víctor Caraballo-Miralles et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes

(2013) Manuela Basso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trophic Factor Gene Therapy for Parkinson's Disease

(2013) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Neuroprotection by astrocytes in brain ischemia: Importance of microRNAs

(2013) Yi-Bing Ouyang et al.   NEUROSCIENCE LETTERS

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

(2013) A. Serio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZ spheres: A stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs

(2013) Allison D. Ebert et al.   Stem Cell Research

Altered astrocytic response to activation in SOD1G93Amice and its implications on amyotrophic lateral sclerosis pathogenesis

(2012) Chen Benkler et al.   GLIA

Motor Neuron Rescue in Spinal Muscular Atrophy Mice Demonstrates That Sensory-Motor Defects Are a Consequence, Not a Cause, of Motor Neuron Dysfunction

(2012) R. G. Gogliotti et al.   JOURNAL OF NEUROSCIENCE

GATA-6 and NF- B Activate CPI-17 Gene Transcription and Regulate Ca2+ Sensitization of Smooth Muscle Contraction

(2012) E. Boopathi et al.   MOLECULAR AND CELLULAR BIOLOGY

Astrocyte-derived GDNF is a potent inhibitor of microglial activation

(2012) Sandra Moreira Rocha et al.   NEUROBIOLOGY OF DISEASE

Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy

(2012) Dhruv Sareen et al.   PLoS One

MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response

(2012) Anand Iyer et al.   PLoS One

Up-regulation of NF-kB-sensitive miRNA-125b and miRNA-146a in metal sulfate-stressed human astroglial (HAG) primary cell cultures

(2011) Aileen I. Pogue et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Not(ch) just development: Notch signalling in the adult brain

(2011) Jessica L. Ables et al.   NATURE REVIEWS NEUROSCIENCE

Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells

(2011) Yuan Yuan Li et al.   NEUROSCIENCE LETTERS

Analysis of microRNA turnover in mammalian cells following Dicer1 ablation

(2011) Michael P. Gantier et al.   NUCLEIC ACIDS RESEARCH

Species-specific microRNA roles elucidated following astrocyte activation

(2011) Eyal Mor et al.   NUCLEIC ACIDS RESEARCH

Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors

(2010) Karim Si-Tayeb et al.   BMC DEVELOPMENTAL BIOLOGY

Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy

(2010) E. Aronica et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models

(2010) Y.Y. Li et al.   NEUROSCIENCE LETTERS

Translational readthrough by the aminoglycoside geneticin (G418) modulates SMN stability in vitro and improves motor function in SMA mice in vivo

(2009) Christopher R. Heier et al.   HUMAN MOLECULAR GENETICS

Notch Signaling Is Required for Activity-Dependent Synaptic Plasticity at theDrosophilaNeuromuscular Junction

(2009) Benjamin Lovegren de Bivort et al.   JOURNAL OF NEUROGENETICS

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells

(2008) Maria C.N. Marchetto et al.   Cell Stem Cell

GATA4 Is Essential for Jejunal Function in Mice

(2008) Michele A. Battle et al.   GASTROENTEROLOGY

Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect

(2008) T. O. Gavrilina et al.   HUMAN MOLECULAR GENETICS

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF  in LPS-stimulated macrophages

(2008) S. Rousseau et al.   JOURNAL OF CELL SCIENCE

Induced pluripotent stem cells from a spinal muscular atrophy patient

(2008) Allison D. Ebert et al.   NATURE

Restoring Bcl-xL levels benefits a mouse model of spinal muscular atrophy

(2008) Li-Kai Tsai et al.   NEUROBIOLOGY OF DISEASE