The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways

Adverse Outcome Pathways and Drug-Induced Liver Injury Testing

(2015) Mathieu Vinken   CHEMICAL RESEARCH IN TOXICOLOGY

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology

(2015) Ksenia J. Groh et al.   CHEMOSPHERE

Adverse Outcome Pathways can drive non-animal approaches for safety assessment

(2015) Natalie Burden et al.   JOURNAL OF APPLIED TOXICOLOGY

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

(2015) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms

(2014) Andreas Bitter et al.   ARCHIVES OF TOXICOLOGY

Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis

(2014) Wen-Lung Ma et al.   ENDOCRINE-RELATED CANCER

Consequences of emergency contraceptives: the adverse effects

(2014) Anne Thomin et al.   Expert Opinion On Drug Safety

On mapping the human toxome

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Vitamin D Receptor Agonists: Suitable Candidates as Novel Therapeutic Options in Autoimmune Inflammatory Myopathy

(2014) Clara Crescioli   Biomed Research International

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways

(2013) Daniel F. Vatner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatic Steatosis with Relation to Increased Expression of Peroxisome Proliferator-Activated Receptor-γ in Insulin Resistant Mice

(2013) Hikaru Satoh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Glucocorticoid-induced osteoporosis: an update on current pharmacotherapy and future directions

(2013) Irene EM Bultink et al.   EXPERT OPINION ON PHARMACOTHERAPY

Retinoids and their biological effects against cancer

(2013) Fatemeh Alizadeh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Immunolocalization of retinoic acid receptor-alpha, -beta, and -gamma, in bovine and canine sperm

(2013) Vanmathy R. Kasimanickam et al.   THERIOGENOLOGY

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction

(2012) Marni N. Silverman et al.   Annals of the New York Academy of Sciences

Corticosteroid Resistance and Novel Anti-Inflammatory Therapies in Chronic Obstructive Pulmonary Disease

(2012) Amir Hakim et al.   DRUGS

Thyroid Hormone Receptor Agonists Reduce Serum Cholesterol Independent of the LDL Receptor

(2012) Jean Z. Lin et al.   ENDOCRINOLOGY

Vitamin D attenuates high fat diet-induced hepatic steatosis in rats by modulating lipid metabolism

(2012) Yi Yin et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Targeting the pregnane X receptor in liver injury

(2012) Tao Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Malonyl-CoA: the regulator of fatty acid synthesis and oxidation

(2012) Daniel W. Foster   JOURNAL OF CLINICAL INVESTIGATION

Epidermal Inactivation of the Glucocorticoid Receptor Triggers Skin Barrier Defects and Cutaneous Inflammation

(2012) Lisa M. Sevilla et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hand Eczema

(2012) Pieter-Jan Coenraads   NEW ENGLAND JOURNAL OF MEDICINE

Risk of cardiovascular events in people prescribed glucocorticoids with iatrogenic Cushing's syndrome: cohort study

(2012) L. Fardet et al.   BMJ-British Medical Journal

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

The kaleidoscope of glucorticoid effects on immune system

(2011) Margherita Zen et al.   AUTOIMMUNITY REVIEWS

n−3 Fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice

(2011) Un Ju Jung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Modulation of RXR function through ligand design

(2011) Efrén Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

(2011) Chibueze A. Ihunnah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glucocorticoid receptor and breast cancer

(2011) Myriam Vilasco et al.   BREAST CANCER RESEARCH AND TREATMENT

The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease

(2011) Jinhan He et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

(2011) M. E. Miquilena-Colina et al.   GUT

In Vivo and In Vitro Characterization of a First-in-Class Novel Azole Analog That Targets Pregnane X Receptor Activation

(2011) M. Venkatesh et al.   MOLECULAR PHARMACOLOGY

Dynamic regulation of glucocorticoid signalling in health and disease

(2011) S. C. Biddie et al.   RHEUMATOLOGY

Intravenous therapies for castration-resistant prostate cancer: Toxicities and adverse events

(2011) Eric A. Singer et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport

(2010) Yuki Kawano et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile

(2010) Marta Moya et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Role of glucocorticoids and the glucocorticoid receptor in metabolism: Insights from genetic manipulations

(2010) Adam J. Rose et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Advancing Exposure Characterization for Chemical Evaluation and Risk Assessment

(2010) Elaine A. Cohen Hubal et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Behavioral insights from mouse models of forebrain- and amygdala-specific glucocorticoid receptor genetic disruption

(2010) Melinda G. Arnett et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Immunotherapy of myositis: issues, concerns and future prospects

(2010) Marinos C. Dalakas   Nature Reviews Rheumatology

Differentiating Intraocular Glucocorticoids

(2010) Jeffrey L. Edelman   OPHTHALMOLOGICA

Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice

(2009) Robert S. Weinstein et al.   AGING CELL

The use of intraocular corticosteroids

(2009) Daniel F Kiernan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Activation of the Nuclear Receptor PXR Decreases Plasma LDL-Cholesterol Levels and Induces Hepatic Steatosis in LDL Receptor Knockout Mice

(2009) Menno Hoekstra et al.   MOLECULAR PHARMACEUTICS

The Role of Propylthiouracil in the Management of Graves' Disease in Adults: Report of a Meeting Jointly Sponsored by the American Thyroid Association and the Food and Drug Administration

(2009) Rebecca S. Bahn et al.   THYROID

PXR and CAR in energy metabolism

(2009) Taira Wada et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion

(2009) William P Harris et al.   Nature clinical practice. Urology

Liver lipid metabolism

(2008) P. Nguyen et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress

(2008) Jodi M. Maglich et al.   JOURNAL OF LIPID RESEARCH

Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

(2008) Mark R Haussler et al.   NUTRITION REVIEWS

Bicalutamide-Associated Fulminant Hepatotoxicity

(2008) Cindy L O'Bryant et al.   PHARMACOTHERAPY

Gene Profiling in the Livers of Wild-type and PPARα-Null Mice Exposed to Perfluorooctanoic Acid

(2008) Mitchell B. Rosen et al.   TOXICOLOGIC PATHOLOGY

Glucocorticoid receptor transgenic mice as models for depression

(2007) Sabine Chourbaji et al.   BRAIN RESEARCH REVIEWS

Xenoreceptors CAR and PXR Activation and Consequences on Lipid Metabolism, Glucose Homeostasis, and Inflammatory Response

(2007) Amélie Moreau et al.   MOLECULAR PHARMACEUTICS