Neuroinflammation as modifier of genetically caused neurological disorders of the central nervous system: Understanding pathogenesis and chances for treatment

SPG2 mimicking multiple sclerosis in a family identified using next generation sequencing

(2017) Anna Rubegni et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Fingolimod and Teriflunomide Attenuate Neurodegeneration in Mouse Models of Neuronal Ceroid Lipofuscinosis

(2017) Janos Groh et al.   MOLECULAR THERAPY

Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy

(2017) Elvira Valera et al.   Acta Neuropathologica Communications

Chronic Traumatic Encephalopathy: The Neuropathological Legacy of Traumatic Brain Injury

(2016) Jennifer Hay et al.   Annual Review of Pathology-Mechanisms of Disease

Immunosenescence of microglia and macrophages: impact on the ageing central nervous system

(2016) Khalil S. Rawji et al.   BRAIN

Myelin and macrophages in the PNS: An intimate relationship in trauma and disease

(2016) Dennis Klein et al.   BRAIN RESEARCH

Steering through complexity

(2016) Bruce A.C. Cree et al.   CURRENT OPINION IN NEUROLOGY

Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS)

(2016) Jonathan M. Van Dyke et al.   EXPERIMENTAL NEUROLOGY

Sialoadhesin promotes neuroinflammation-related disease progression in two mouse models of CLN disease

(2016) Janos Groh et al.   GLIA

Proteolipid protein–deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling

(2016) Xinghua Yin et al.   JOURNAL OF CELL BIOLOGY

Induction of the type I interferon response in neurological forms of Gaucher disease

(2016) Einat B. Vitner et al.   Journal of Neuroinflammation

Biochemical, cell biological, pathological, and therapeutic aspects of Krabbe's disease

(2016) Je-Seong Won et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Is involvement of inflammation underestimated in Pelizaeus-Merzbacher disease?

(2016) Antoine Marteyn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuroimmune mechanisms in Krabbe's disease

(2016) Gregory B. Potter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Gene therapy for metachromatic leukodystrophy

(2016) Jonathan B. Rosenberg et al.   JOURNAL OF NEUROSCIENCE RESEARCH

RAGE axis in neuroinflammation, neurodegeneration and its emerging role in the pathogenesis of amyotrophic lateral sclerosis

(2016) Rashmi Ray et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis

(2016) Ryan D. Geraets et al.   Orphanet Journal of Rare Diseases

A rare case of SPG11 mutation with multiple sclerosis

(2016) C. Laurencin et al.   REVUE NEUROLOGIQUE

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease

(2016) M. Joana Osorio et al.   STEM CELLS

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

(2016) Violeta Chitu et al.   TRENDS IN NEUROSCIENCES

Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice

(2016) Judyta K. Juranek et al.   Frontiers in Cellular Neuroscience

Metachromatic leukodystrophy: Disease spectrum and approaches for treatment

(2015) Diane F. van Rappard et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Genetics of the neuronal ceroid lipofuscinoses (Batten disease)

(2015) Sara E. Mole et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cell biology of the NCL proteins: What they do and don't do

(2015) Jaime Cárcel-Trullols et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Towards a new understanding of NCL pathogenesis

(2015) Jonathan D. Cooper et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuroinflammation in the peripheral nerve: Cause, modulator, or bystander in peripheral neuropathies?

(2015) Rudolf Martini et al.   GLIA

A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches

(2015) V. V. Bashinskaya et al.   HUMAN GENETICS

Emerging mechanisms of molecular pathology in ALS

(2015) Owen M. Peters et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-inflammatory Therapy With Simvastatin Improves Neuroinflammation and CNS Function in a Mouse Model of Metachromatic Leukodystrophy

(2015) Axel Stein et al.   MOLECULAR THERAPY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Neuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications

(2015) Stefan Bittner et al.   Neurotherapeutics

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

Multiple-System Atrophy

(2015) Alessandra Fanciulli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical and genetic heterogeneity in hereditary spastic paraplegias: From SPG1 to SPG72 and still counting

(2015) S. Klebe et al.   REVUE NEUROLOGIQUE

AAV gene transfer delays disease onset in a TPP1-deficient canine model of the late infantile form of Batten disease

(2015) Martin L. Katz et al.   Science Translational Medicine

Modulation of the Innate Immune Response by Human Neural Precursors Prevails over Oligodendrocyte Progenitor Remyelination to Rescue a Severe Model of Pelizaeus-Merzbacher Disease

(2015) Antoine Marteyn et al.   STEM CELLS

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease

(2015) Siddhita D. Mhatre et al.   TRENDS IN NEUROSCIENCES

Inflammatory reaction after traumatic brain injury: therapeutic potential of targeting cell–cell communication by chemokines

(2015) Stefka Gyoneva et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation

(2015) Bruno Di Marco Vieira et al.   Frontiers in Cellular Neuroscience

Atypical hereditary spastic paraplegia mimicking multiple sclerosis associated with a novel SPG11 mutation

(2014) A. Romagnolo et al.   EUROPEAN JOURNAL OF NEUROLOGY

An Anti-Neuroinflammatory That Targets Dysregulated Glia Enhances the Efficacy of CNS-Directed Gene Therapy in Murine Infantile Neuronal Ceroid Lipofuscinosis

(2014) S. L. Macauley et al.   JOURNAL OF NEUROSCIENCE

ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo

(2014) Brian Spencer et al.   MOLECULAR THERAPY

RIPK3 as a potential therapeutic target for Gaucher's disease

(2014) Einat B Vitner et al.   NATURE MEDICINE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann–Pick disease type C1 mice

(2014) Ian M. Williams et al.   NEUROBIOLOGY OF DISEASE

Non-invasive assessment of retinal alterations in mouse models of infantile and juvenile neuronal ceroid lipofuscinosis by spectral domain optical coherence tomography

(2014) Janos Groh et al.   Acta Neuropathologica Communications

Similarities between Inherited Demyelinating Neuropathies and Wallerian Degeneration

(2013) Rudolf Martini et al.   AMERICAN JOURNAL OF PATHOLOGY

NCL disease mechanisms

(2013) David N. Palmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pathophysiology of X-linked adrenoleukodystrophy

(2013) J. Berger et al.   BIOCHIMIE

Molecular triggers of neuroinflammation in mouse models of demyelinating diseases

(2013) Benoit Barrette et al.   BIOLOGICAL CHEMISTRY

Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis

(2013) Janos Groh et al.   BRAIN

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Treating multiple sclerosis with monoclonal antibodies: a 2013 update

(2013) Annika Deiß et al.   Expert Review of Neurotherapeutics

Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy

(2013) Elvira Valera et al.   GLIA

Deletion of tumor necrosis factor-α ameliorates neurodegeneration in Sandhoff disease mice

(2013) Hatem Abo-ouf et al.   HUMAN MOLECULAR GENETICS

Human and mouse neuroinflammation markers in Niemann-Pick disease, type C1

(2013) Stephanie M. Cologna et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mucopolysaccharide diseases: A complex interplay between neuroinflammation, microglial activation and adaptive immunity

(2013) Louise D. Archer et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Microglia in juvenile neuronal ceroid lipofuscinosis are primed toward a pro-inflammatory phenotype

(2013) Juan Xiong et al.   JOURNAL OF NEUROCHEMISTRY

Lysosomal storage diseases—the horizon expands

(2013) Rose-Mary Naaman Boustany   Nature Reviews Neurology

Rare neurological diseases: A Pandora's box for neurology (an European and Italian perspective)

(2013) A. Federico   REVUE NEUROLOGIQUE

Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy

(2013) A. Biffi et al.   SCIENCE

Polyclonal immunoglobulin G for autoimmune demyelinating nervous system disorders

(2013) Mathias Buttmann et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The neuronal ceroid-lipofuscinoses: A historical introduction

(2012) Matti Haltia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease

(2012) Einat B. Vitner et al.   BRAIN

Abnormal Regenerative Responses and Impaired Axonal Outgrowth after Nerve Crush in TDP-43 Transgenic Mouse Models of Amyotrophic Lateral Sclerosis

(2012) V. Swarup et al.   JOURNAL OF NEUROSCIENCE

Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

(2012) Gesine Saher et al.   NATURE MEDICINE

Peripheral nerve inflammation in ALS mice: cause or consequence

(2012) O. Kano et al.   NEUROLOGY

Neuropathology in Mouse Models of Mucopolysaccharidosis Type I, IIIA and IIIB

(2012) Fiona L. Wilkinson et al.   PLoS One

Neuroinflammation by Cytotoxic T-Lymphocytes Impairs Retrograde Axonal Transport in an Oligodendrocyte Mutant Mouse

(2012) Chi Wang Ip et al.   PLoS One

Genetics of Hereditary Spastic Paraplegias

(2012) Rebecca Schüle et al.   SEMINARS IN NEUROLOGY

Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot–Marie–Tooth disease type 1X

(2011) Janos Groh et al.   BRAIN

Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease

(2011) Fredrik I. Gruenenfelder et al.   JOURNAL OF ANATOMY

Macrophages Counteract Demyelination in a Mouse Model of Globoid Cell Leukodystrophy

(2011) Y. Kondo et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: The positive effect of long-term aspirin treatment

(2011) Audrey Arfi et al.   MOLECULAR GENETICS AND METABOLISM

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Myeloperoxidase Inhibition Ameliorates Multiple System Atrophy-Like Degeneration in a Transgenic Mouse Model

(2011) Nadia Stefanova et al.   NEUROTOXICITY RESEARCH

Mesenchymal Stem Cells in a Transgenic Mouse Model of Multiple System Atrophy: Immunomodulation and Neuroprotection

(2011) Sylvia Stemberger et al.   PLoS One

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease

(2010) Julia M. Edgar et al.   EMBO Molecular Medicine

Immunosuppression alters disease severity in juvenile Batten disease mice

(2010) Sabrina S. Seehafer et al.   JOURNAL OF NEUROIMMUNOLOGY

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

(2010) Smruti Killedar et al.   Journal of Neuroinflammation

Metachromatic Leukodystrophy – An Update

(2010) V. Gieselmann et al.   NEUROPEDIATRICS

Niemann-Pick disease type C

(2010) Marie T Vanier   Orphanet Journal of Rare Diseases

Ectopic T-Cell Specificity and Absence of Perforin and Granzyme B Alleviate Neural Damage in Oligodendrocyte Mutant Mice

(2009) Antje Kroner et al.   AMERICAN JOURNAL OF PATHOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Mucopolysaccharidosis IIIB: Oxidative damage and cytotoxic cell involvement in the neuronal pathogenesis

(2009) Guglielmo R.D. Villani et al.   BRAIN RESEARCH

Effects of treatments on inflammatory and apoptotic markers in the CNS of mice with globoid cell leukodystrophy

(2009) Paola Luzi et al.   BRAIN RESEARCH

Minocycline 1-year therapy in multiple-system-atrophy: Effect on clinical symptoms and [11C](R)-PK11195 PET (MEMSA-trial)

(2009) Richard Dodel et al.   MOVEMENT DISORDERS

Beneficial effects of anti-inflammatory therapy in a mouse model of Niemann-Pick disease type C1

(2009) David Smith et al.   NEUROBIOLOGY OF DISEASE

PD-1 Regulates Neural Damage in Oligodendroglia-Induced Inflammation

(2009) Antje Kroner et al.   PLoS One

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

(2009) N. Cartier et al.   SCIENCE

Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) and the Eye

(2009) Sara Bozorg et al.   SURVEY OF OPHTHALMOLOGY

RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis

(2008) Arjun Saha et al.   FEBS LETTERS

Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture

(2008) S. Hein et al.   HUMAN MOLECULAR GENETICS

Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB−/− mouse model of neurodegeneration

(2008) Stephanos Kyrkanides et al.   JOURNAL OF NEUROIMMUNOLOGY

Innate and adaptive immune activation in the brain of MPS IIIB mouse model

(2008) Julianne DiRosario et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The co-inhibitory molecule PD-1 modulates disease severity in a model for an inherited, demyelinating neuropathy

(2008) Antje Kroner et al.   NEUROBIOLOGY OF DISEASE