Journal
REVUE NEUROLOGIQUE
Volume 172, Issue 6-7, Pages 389-391Publisher
MASSON EDITEUR
DOI: 10.1016/j.neurol.2016.03.006
Keywords
Multiple sclerosis; Hereditary spastic paraplegia; SPG1; Demyelinating disease; Spatacsin
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We describe a patient with SPG11 hereditary spastic paraplegia (HSP), who developed walking disorder in childhood. He presented three episodes of subacute gait disorders worsening between the age of 20 and 22 years. Brain and spinal MRI revealed multiple T2 hypersignal lesions, consistent with inflammatory lesions. Surprisingly, CSF analysis showed neither oligoclonal bands nor increased IgG index. He was dramatically improved by intravenous methylprednisolone. A relapsing-remitting multiple sclerosis (MS) was suspected. This is the first description of SPG11 HSP associated with MS. (C) 2016 Elsevier Masson SAS. All rights reserved.
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