Microglia in juvenile neuronal ceroid lipofuscinosis are primed toward a pro-inflammatory phenotype

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice

(2012) Yuka Kobayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functions of connexins and large pore channels on microglial cells: The gates to environment

(2012) Thomas Mika et al.   BRAIN RESEARCH

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons

(2012) Michael V.L. Bennett et al.   BRAIN RESEARCH

Ceramide function in the brain: when a slight tilt is enough

(2012) Chiara Mencarelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microglia are required for astroglial toll-like receptor 4 response and for optimal TLR2 and TLR3 response

(2012) Thomas H. Holm et al.   GLIA

The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol

(2012) Arjun Saha et al.   HUMAN MOLECULAR GENETICS

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System

(2012) Eliseo A. Eugenin et al.   Journal of Neuroimmune Pharmacology

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Large-Scale Phenotyping of an Accurate Genetic Mouse Model of JNCL Identifies Novel Early Pathology Outside the Central Nervous System

(2012) John F. Staropoli et al.   PLoS One

Induction of Neuronal Death by Microglial AGE-Albumin: Implications for Alzheimer’s Disease

(2012) Kyunghee Byun et al.   PLoS One

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor (TLR) and inflammasome actions in the central nervous system

(2012) Richa Hanamsagar et al.   TRENDS IN IMMUNOLOGY

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

(2012) Manuela Rossol et al.   Nature Communications

Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts

(2011) Lisa Fellner et al.   ACTA NEUROPATHOLOGICA

Aberrant Upregulation of Astroglial Ceramide Potentiates Oligodendrocyte Injury

(2011) SunJa Kim et al.   BRAIN PATHOLOGY

The Batten disease gene CLN3 is required for the response to oxidative stress

(2011) Richard I. Tuxworth et al.   HUMAN MOLECULAR GENETICS

A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses

(2011) Reza M. Salek et al.   JOURNAL OF BIOMOLECULAR NMR

Ethyl Pyruvate Rescues Nigrostriatal Dopaminergic Neurons by Regulating Glial Activation in a Mouse Model of Parkinson's Disease

(2011) S. H. Huh et al.   JOURNAL OF IMMUNOLOGY

Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia

(2011) Richa Hanamsagar et al.   JOURNAL OF NEUROCHEMISTRY

MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection†

(2011) Shuliang Liu et al.   Journal of Neuroinflammation

Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity

(2011) N. Karpuk et al.   JOURNAL OF NEUROSCIENCE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Altered sensitivity of cerebellar granule cells to glutamate receptor overactivation in the Cln3Δex7/8-knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

(2011) Rozzy Finn et al.   NEUROCHEMISTRY INTERNATIONAL

Brain-derived neurotrophic factor promotes adaptive plasticity within the spinal cord and mediates the beneficial effects of controllable stimulation

(2011) J.R. Huie et al.   NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Distinct Early Molecular Responses to Mutations Causing vLINCL and JNCL Presage ATP Synthase Subunit C Accumulation in Cerebellar Cells

(2011) Yi Cao et al.   PLoS One

Interleukin-15 biology and its therapeutic implications in cancer

(2011) Jason C. Steel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase

(2010) Erin G. Rosenbaugh et al.   BIOMATERIALS

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function

(2010) Amanda L. Getty et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunosuppression alters disease severity in juvenile Batten disease mice

(2010) Sabrina S. Seehafer et al.   JOURNAL OF NEUROIMMUNOLOGY

Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate

(2010) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease

(2010) Attila D. Kovács et al.   NEUROPHARMACOLOGY

Mutant superoxide dismutase 1-induced IL-1  accelerates ALS pathogenesis

(2010) F. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurodevelopmental delay in theCln3Δex7/8mouse model for Batten disease

(2009) N. S. Osório et al.   GENES BRAIN AND BEHAVIOR

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Global Mapping of the Topography and Magnitude of Proteolytic Events in Apoptosis

(2008) Melissa M. Dix et al.   CELL

Glial connexins and gap junctions in CNS inflammation and disease

(2008) Tammy Kielian   JOURNAL OF NEUROCHEMISTRY

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Developmental impairments of select neurotransmitter systems in brains ofCln3Δex7/8 knock-in mice, an animal model of juvenile neuronal ceroid lipofuscinosis

(2008) Philipp Herrmann et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Attenuation of AMPA receptor activity improves motor skills in a mouse model of juvenile Batten disease

(2007) Attila D. Kovács et al.   EXPERIMENTAL NEUROLOGY