Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination

Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation

(2017) Veit Rothhammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation

(2016) Filip Petković et al.   GLIA

Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model

(2016) T. Draheim et al.   GLIA

The crucial role of Erk2 in demyelinating inflammation in the central nervous system

(2016) Rentaro Okazaki et al.   Journal of Neuroinflammation

Activation of oligodendroglial Stat3 is required for efficient remyelination

(2016) Andrew J. Steelman et al.   NEUROBIOLOGY OF DISEASE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

CXCL10 Triggers Early Microglial Activation in the Cuprizone Model

(2015) Tim Clarner et al.   JOURNAL OF IMMUNOLOGY

Long-term effects of fingolimod in multiple sclerosis: The randomized FREEDOMS extension trial

(2015) L. Kappos et al.   NEUROLOGY

The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination

(2014) A Slowik et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms of white matter damage in multiple sclerosis

(2014) Hans Lassmann   GLIA

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

(2014) Viktoria Gudi et al.   Frontiers in Cellular Neuroscience

Puma, but not noxa is essential for oligodendroglial cell death

(2013) Karin Hagemeier et al.   GLIA

Circulating Monocytes Are Reduced by Sphingosine-1-Phosphate Receptor Modulators Independently of S1P3

(2013) N. D. Lewis et al.   JOURNAL OF IMMUNOLOGY

Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

(2013) Aran Groves et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation

(2013) Christopher S Garris et al.   NATURE IMMUNOLOGY

Cuprizone short-term exposure: Astrocytic IL-6 activation and behavioral changes relevant to psychosis

(2013) Tomoaki Tezuka et al.   NEUROBIOLOGY OF DISEASE

Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions

(2013) Corinne Brana et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

(2012) Ruben van Doorn et al.   ACTA NEUROPATHOLOGICA

FTY720 Improves Functional Recovery after Spinal Cord Injury by Primarily Nonimmunomodulatory Mechanisms

(2012) Yusuke Norimatsu et al.   AMERICAN JOURNAL OF PATHOLOGY

A Novel Regulator of Macrophage Activation

(2012) Guoqing Zhuang et al.   CIRCULATION

Interleukin-6, a Major Cytokine in the Central Nervous System

(2012) María Erta et al.   International Journal of Biological Sciences

Abbreviated exposure to cuprizone is sufficient to induce demyelination and oligodendrocyte loss

(2012) Vivian Doan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Fingolimod and multiple sclerosis: Four cautionary tales

(2012) D. Bourdette et al.   NEUROLOGY

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system

(2011) Jenni Raasch et al.   BRAIN

Aberrant Upregulation of Astroglial Ceramide Potentiates Oligodendrocyte Injury

(2011) SunJa Kim et al.   BRAIN PATHOLOGY

Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model

(2011) Hye Jung Kim et al.   FASEB JOURNAL

Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo

(2011) Yinghui Hu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication

(2011) Andrew J. Steelman et al.   NEUROSCIENCE RESEARCH

Spatial and Temporal Profiles of Growth Factor Expression during CNS Demyelination Reveal the Dynamics of Repair Priming

(2011) Viktoria Gudi et al.   PLoS One

Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices

(2010) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients

(2010) Trina A. Johnson et al.   CLINICAL IMMUNOLOGY

Neurons and Oligodendrocytes Recycle Sphingosine 1-Phosphate to Ceramide

(2010) Jingdong Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Localization of Sphingosine-1-phosphate Receptor 1 Expression in the Human Central Nervous System

(2010) Hirotake Nishimura et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Astrocytes promote TNF-mediated toxicity to oligodendrocyte precursors

(2010) SunJa Kim et al.   JOURNAL OF NEUROCHEMISTRY

CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis

(2010) LiPing Liu et al.   NATURE NEUROSCIENCE

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

MHC class II exacerbates demyelination in vivo independently of T cells

(2008) Meenaxi M. Hiremath et al.   JOURNAL OF NEUROIMMUNOLOGY

Tumor Necrosis Factor   Mediates Lipopolysaccharide-Induced Microglial Toxicity to Developing Oligodendrocytes When Astrocytes Are Present

(2008) J. Li et al.   JOURNAL OF NEUROSCIENCE

Central nervous system-directed effects of FTY720 (fingolimod)

(2008) Veronique E. Miron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions

(2008) P. J. Gonzalez-Cabrera et al.   MOLECULAR PHARMACOLOGY