The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination

Investigation of immune and CNS-mediated effects of fingolimod in the focal delayed-type hypersensitivity multiple sclerosis model

(2014) Daniel C. Anthony et al.   NEUROPHARMACOLOGY

Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: Comparison with Memantine

(2013) Fatemeh Hemmati et al.   BEHAVIOURAL BRAIN RESEARCH

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease

(2013) Alba Di Pardo et al.   HUMAN MOLECULAR GENETICS

Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions

(2013) Corinne Brana et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Impact of Fingolimod Therapy on Magnetic Resonance Imaging Outcomes in Patients With Multiple Sclerosis

(2012) Ernst-Wilhelm Radue   ARCHIVES OF NEUROLOGY

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Endogeneous Remyelination: Findings in Human Studies

(2012) Markus Kipp et al.   CNS & Neurological Disorders-Drug Targets

Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions

(2012) Tim Clarner et al.   GLIA

Systematic Review and Meta-Analysis of the Efficacy of Sphingosine-1-Phosphate (S1P) Receptor Agonist FTY720 (Fingolimod) in Animal Models of Stroke

(2012) Junfeng Liu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Inflammatory Response and Chemokine Expression in the White Matter Corpus Callosum and Gray Matter Cortex Region During Cuprizone-Induced Demyelination

(2012) J. P. Buschmann et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study

(2012) Virginia Devonshire et al.   LANCET NEUROLOGY

FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination

(2012) M Kipp et al.   Multiple Sclerosis Journal

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Late motor decline after accomplished remyelination: Impact for progressive multiple sclerosis

(2011) Natalia Manrique-Hoyos et al.   ANNALS OF NEUROLOGY

BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions

(2011) M. Kipp et al.   BRAIN BEHAVIOR AND IMMUNITY

Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model

(2011) Hye Jung Kim et al.   FASEB JOURNAL

Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo

(2011) Yinghui Hu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis

(2011) Sarah Al-Izki et al.   Multiple Sclerosis Journal

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Fibroblast growth factor 1 (FGFR1) modulation regulates repair capacity of oligodendrocyte progenitor cells following chronic demyelination

(2011) Yong-Xing Zhou et al.   NEUROBIOLOGY OF DISEASE

Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions

(2011) Iris Fischer et al.   PLoS One

Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices

(2010) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

ADAM12 is expressed by astrocytes during experimental demyelination

(2010) Fabian Baertling et al.   BRAIN RESEARCH

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(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Fingolimod is a potential novel therapy for multiple sclerosis

(2010) Orhan Aktas et al.   Nature Reviews Neurology

Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis

(2010) Alina Kułakowska et al.   NEUROSCIENCE LETTERS

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses

(2009) Dimitrios Papadopoulos et al.   JOURNAL OF NEUROSCIENCE RESEARCH

FTY720 Reduces Inflammation and Promotes Functional Recovery after Spinal Cord Injury

(2009) Kangmin D. Lee et al.   JOURNAL OF NEUROTRAUMA

Gray matter pathology in (chronic) MS: Modern views on an early observation

(2009) Jeroen J.G. Geurts et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination

(2009) Maren Lindner et al.   NEUROSCIENCE LETTERS

Extensive remyelination of the CNS leads to functional recovery

(2009) I. D. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

(2009) Yu Hasegawa et al.   STROKE

Cyclical and Dose-Dependent Responses of Adult Human Mature Oligodendrocytes to Fingolimod

(2008) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

Cortical Demyelination Is Prominent in the Murine Cuprizone Model and Is Strain-Dependent

(2008) Thomas Skripuletz et al.   AMERICAN JOURNAL OF PATHOLOGY

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

(2008) David Wheeler et al.   BRAIN

Remyelination protects axons from demyelination-associated axon degeneration

(2008) K. A. Irvine et al.   BRAIN

17β-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice

(2008) Peter Acs et al.   GLIA

Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease

(2008) Yun-Ping Wu et al.   HUMAN MOLECULAR GENETICS

Grey matter pathology in multiple sclerosis

(2008) Jeroen JG Geurts et al.   LANCET NEUROLOGY

Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

(2008) Eva Herrero-Herranz et al.   NEUROBIOLOGY OF DISEASE

FTY720 modulates human oligodendrocyte progenitor process extension and survival

(2007) Veronique E. Miron et al.   ANNALS OF NEUROLOGY