Protein phosphatase 2A and tau: an orchestrated ‘Pas de Deux’

Folic Acid Reduces Tau Phosphorylation by Regulating PP2A Methylation in Streptozotocin-Induced Diabetic Mice

(2017) Miaoyan Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

(2017) Jaya Sangodkar et al.   JOURNAL OF CLINICAL INVESTIGATION

The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton

(2017) Alexander Hoffman et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The protumorigenic potential of FTY720 by promoting extramedullary hematopoiesis and MDSC accumulation

(2017) Y Li et al.   ONCOGENE

Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus

(2017) Jee Hyun Yi et al.   PHARMACOLOGICAL RESEARCH

Biphasic Effects of Forskolin on Tau Phosphorylation and Spatial Memory in Rats

(2017) Qing Tian et al.   JOURNAL OF ALZHEIMERS DISEASE

Anesthesia Induces Phosphorylation of Tau

(2017) Xiaoqin Run et al.   JOURNAL OF ALZHEIMERS DISEASE

PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

(2017) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation

(2016) Núbia Broetto et al.   BRAIN RESEARCH BULLETIN

Alterations in Glucose Metabolism on Cognition: A Possible Link Between Diabetes and Dementia

(2016) Rodrigo E. González-Reyes et al.   CURRENT PHARMACEUTICAL DESIGN

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

(2016) S. Meier et al.   JOURNAL OF NEUROSCIENCE

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

(2016) Erica Barini et al.   Molecular Neurodegeneration

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

(2016) Arne Ittner et al.   SCIENCE

Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation

(2016) Xu-Ying Sun et al.   Cell Death & Disease

Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase

(2015) Elisabetta Lauretti et al.   AGING CELL

Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines

(2015) Di Xia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters

(2015) Torsten Bullmann et al.   HIPPOCAMPUS

Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD

(2015) P. Regan et al.   JOURNAL OF NEUROSCIENCE

Tau Mislocation in Glucocorticoid-Triggered Hippocampal Pathology

(2015) Sara Pinheiro et al.   MOLECULAR NEUROBIOLOGY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro

(2015) Robert A. Whittington et al.   NEUROBIOLOGY OF AGING

Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons

(2015) R. Li et al.   NEUROSCIENCE

PP2A–B56ϵ complex is involved in dephosphorylation of γ-H2AX in the repair process of CPT-induced DNA double-strand breaks

(2015) Xiuying Li et al.   TOXICOLOGY

The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease

(2015) Naoyuki Sato et al.   Frontiers in Aging Neuroscience

Sevoflurane Induces Tau Phosphorylation and Glycogen Synthase Kinase 3β Activation in Young Mice

(2014) Guorong Tao et al.   ANESTHESIOLOGY

Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A

(2014) Stéphanie Chasseigneaux et al.   BMC NEUROSCIENCE

A coupled model of fast axonal transport of organelles and slow axonal transport of tau protein

(2014) I.A. Kuznetsov et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Metabolic Control of Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Caspase-2 Suppression by the B55β/Protein Phosphatase 2A (PP2A)

(2014) Bofu Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells

(2014) W. Li et al.   Journal of Nutrition Health & Aging

Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation

(2014) Un Young Yu et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

What tau distribution maximizes fast axonal transport toward the axonal synapse?

(2014) I.A. Kuznetsov et al.   MATHEMATICAL BIOSCIENCES

Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease

(2014) Gustavo Basurto-Islas et al.   NEUROBIOLOGY OF AGING

Thermodynamics of the Interaction between Alzheimer's Disease Related Tau Protein and DNA

(2014) Sergio Camero et al.   PLoS One

Visualizing the microtubule-associated protein tau in the nucleus

(2014) Jing Lu et al.   Science China-Life Sciences

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

(2014) Marie Violet et al.   Frontiers in Cellular Neuroscience

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Protein phosphatase 2A dysfunction in Alzheimer’s disease

(2014) Jean-Marie Sontag et al.   Frontiers in Molecular Neuroscience

Neuropathology of stress

(2013) Paul J. Lucassen et al.   ACTA NEUROPATHOLOGICA

Neuronal plasticity in hibernation and the proposed role of the microtubule-associated protein tau as a “master switch” regulating synaptic gain in neuronal networks

(2013) Thomas Arendt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Leucine Carboxyl Methyltransferase 1 (LCMT1)-dependent Methylation Regulates the Association of Protein Phosphatase 2A and Tau Protein with Plasma Membrane Microdomains in Neuroblastoma Cells

(2013) Jean-Marie Sontag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein phosphatase 2A: a target for anticancer therapy

(2013) Danilo Perrotti et al.   LANCET ONCOLOGY

SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients

(2013) Patricia Facchinetti et al.   NEUROBIOLOGY OF AGING

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

(2013) T. Kimura et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Xanthoceraside attenuates tau hyperphosphorylation and cognitive deficits in intracerebroventricular-streptozotocin injected rats

(2013) Peng Liu et al.   PSYCHOPHARMACOLOGY

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Tau Phosphorylation and Sevoflurane Anesthesia

(2012) Hélène Le Freche et al.   ANESTHESIOLOGY

Loss of PPP2R2A Inhibits Homologous Recombination DNA Repair and Predicts Tumor Sensitivity to PARP Inhibition

(2012) P. Kalev et al.   CANCER RESEARCH

The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity

(2012) Ward Sents et al.   FEBS Journal

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

Interaction of Endogenous Tau Protein with Synaptic Proteins Is Regulated byN-Methyl-d-aspartate Receptor-dependent Tau Phosphorylation

(2012) Siddhartha Mondragón-Rodríguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Protein Phosphatase PP2A/Bα Binds to the Microtubule-associated Proteins Tau and MAP2 at a Motif Also Recognized by the Kinase Fyn

(2012) Jean-Marie Sontag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation

(2012) Yan Xiong et al.   NEUROBIOLOGY OF AGING

The Apolipoprotein-E-Mimetic COG112 Protects Amyloid Precursor Protein Intracellular Domain-Overexpressing Animals from Alzheimer's Disease-Like Pathological Features

(2012) Kaushik Ghosal et al.   Neurodegenerative Diseases

Mild traumatic brain injury: a risk factor for neurodegeneration

(2012) Brandon E Gavett et al.   Alzheimers Research & Therapy

Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2PP2A/SET

(2011) Lisette Arnaud et al.   FEBS LETTERS

Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro

(2011) Ling Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Apolipoprotein E and Peptide Mimetics Modulate Inflammation by Binding the SET Protein and Activating Protein Phosphatase 2A

(2011) D. J. Christensen et al.   JOURNAL OF IMMUNOLOGY

Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

(2011) C H Switzer et al.   ONCOGENE

Molecular Implication of PP2A and Pin1 in the Alzheimer's Disease Specific Hyperphosphorylation of Tau

(2011) Isabelle Landrieu et al.   PLoS One

Mice lacking phosphatase PP2A subunit PR61/B'  (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3 

(2011) J. V. Louis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Fyn-Tau-Amyloid: A Toxic Triad

(2010) Christian Haass et al.   CELL

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer’s disease model

(2010) Niall M. Corcoran et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule-associated protein tau in human prostate cancer cells: Isoforms, phosphorylation, and interactions

(2009) Skye Souter et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Protein Phosphatase 2A-Dependent Dephosphorylation of Replication Protein A Is Required for the Repair of DNA Breaks Induced by Replication Stress

(2009) J. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease

(2008) Siddhartha Mondragón-Rodríguez et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Tau Mutations in Neurodegenerative Diseases

(2008) Michael S. Wolfe   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological regulation of tau phosphorylation during hibernation

(2008) Bo Su et al.   JOURNAL OF NEUROCHEMISTRY

Folate Deficiency Induces In Vitro and Mouse Brain Region-Specific Downregulation of Leucine Carboxyl Methyltransferase-1 and Protein Phosphatase 2A B  Subunit Expression That Correlate with Enhanced Tau Phosphorylation

(2008) J.-M. Sontag et al.   JOURNAL OF NEUROSCIENCE

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

(2008) Yanhui Xu et al.   MOLECULAR CELL

Binding to the Minor Groove of the Double-Strand, Tau Protein Prevents DNA from Damage by Peroxidation

(2008) Yan Wei et al.   PLoS One

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Spatial control of protein phosphatase 2A (de)methylation

(2007) Sari Longin et al.   EXPERIMENTAL CELL RESEARCH