A new strategy for treating hypertension by blocking the activity of the brain renin–angiotensin system with aminopeptidase A inhibitors

Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug

(2013) Fabrice Balavoine et al.   CLINICAL PHARMACOKINETICS

Structural Insights into Central Hypertension Regulation by Human Aminopeptidase A

(2013) Yang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mass spectrometry for the molecular imaging of angiotensin metabolism in kidney

(2012) Nadja Grobe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of brain angiotensin III attenuates sympathetic hyperactivity and cardiac dysfunction in rats post-myocardial infarction

(2012) Bing S. Huang et al.   CARDIOVASCULAR RESEARCH

Angiotensin-(1–7): beyond the cardio-renal actions

(2012) Danielle G. Passos-Silva et al.   CLINICAL SCIENCE

Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats

(2012) Yannick Marc et al.   HYPERTENSION

Initial Combination Therapy Reduces the Risk of Cardiovascular Events in Hypertensive Patients

(2012) Alan H. Gradman et al.   HYPERTENSION

The role of the brain renin–angiotensin system in hypertension: Implications for new treatment

(2011) Yannick Marc et al.   PROGRESS IN NEUROBIOLOGY

The Brain Renin-Angiotensin System Controls Divergent Efferent Mechanisms to Regulate Fluid and Energy Balance

(2010) Justin L. Grobe et al.   Cell Metabolism

Drug Therapy for Resistant Hypertension: Simplifying the Approach

(2010) Samuel J. Mann   Journal of Clinical Hypertension

Identification of Threonine 348 as a Residue Involved in Aminopeptidase A Substrate Specificity

(2009) Cédric Claperon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asp218participates with Asp213to bind a Ca2+atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity

(2008) Cédric Claperon et al.   BIOCHEMICAL JOURNAL

Orally Active Aminopeptidase A Inhibitors Reduce Blood Pressure

(2008) Laurence Bodineau et al.   HYPERTENSION

Resistant Hypertension: Diagnosis, Evaluation, and Treatment

(2008) David A. Calhoun et al.   HYPERTENSION

Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei

(2008) Nadia de Mota et al.   JOURNAL OF NEUROCHEMISTRY

Global burden of blood-pressure-related disease, 2001

(2008) Carlene MM Lawes et al.   LANCET

Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients

(2008) Kenneth Jamerson et al.   NEW ENGLAND JOURNAL OF MEDICINE