Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly

Comprehensive classification of the PIN domain-like superfamily

(2017) Dorota Matelska et al.   NUCLEIC ACIDS RESEARCH

Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides

(2017) Sung-Min Kang et al.   NUCLEIC ACIDS RESEARCH

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation

(2016) Kristoffer Winther et al.   NUCLEIC ACIDS RESEARCH

Dual Role of a Biosynthetic Enzyme, CysK, in Contact Dependent Growth Inhibition in Bacteria

(2016) Soni Kaundal et al.   PLoS One

Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways

(2016) Meenakumari Muthuramalingam et al.   Toxins

Structural and functional studies of theMycobacterium tuberculosisVapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides

(2015) In-Gyun Lee et al.   NUCLEIC ACIDS RESEARCH

MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs

(2015) Prabhakar Tiwari et al.   Nature Communications

Molecular Mechanisms Underlying Bacterial Persisters

(2014) Etienne Maisonneuve et al.   CELL

Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin–antitoxin assembly

(2014) Uddipan Das et al.   JOURNAL OF STRUCTURAL BIOLOGY

VapC from the Leptospiral VapBC Toxin-Antitoxin Module Displays Ribonuclease Activity on the Initiator tRNA

(2014) Alexandre P. Y. Lopes et al.   PLoS One

Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis

(2014) Ambre Sala et al.   Toxins

Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity

(2014) Yurong Wen et al.   Pathogens and Disease

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

Polyphosphate Deficiency in Mycobacterium tuberculosis Is Associated with Enhanced Drug Susceptibility and Impaired Growth in Guinea Pigs

(2013) R. Singh et al.   JOURNAL OF BACTERIOLOGY

Scalable web services for the PSIPRED Protein Analysis Workbench

(2013) Daniel W. A. Buchan et al.   NUCLEIC ACIDS RESEARCH

Bacterial lifestyle shapes stringent response activation

(2013) Cara C. Boutte et al.   TRENDS IN MICROBIOLOGY

VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

(2013) Kristoffer S. Winther et al.   Nature Communications

A VapBC Toxin-Antitoxin Module Is a Posttranscriptional Regulator of Metabolic Flux in Mycobacteria

(2012) J. L. McKenzie et al.   JOURNAL OF BACTERIOLOGY

Molecular Structure and Function of the Novel BrnT/BrnA Toxin-Antitoxin System ofBrucella abortus

(2012) Brook E. Heaton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Enteric vapBC Transcription: Induction by VapC Toxin Dimer-Breaking

(2012) Kristoffer S. Winther et al.   NUCLEIC ACIDS RESEARCH

Regulation of the vapBC-1 Toxin-Antitoxin Locus in Nontypeable Haemophilus influenzae

(2012) Susan D. Cline et al.   PLoS One

The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex fromM. tuberculosisreveals a Mg2+ion in the active site and a putative RNA-binding site

(2012) Andrew B. Min et al.   PROTEIN SCIENCE

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

(2011) Xiaoxue Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly

(2011) Christian Dienemann et al.   JOURNAL OF MOLECULAR BIOLOGY

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance

(2010) R. Singh et al.   JOURNAL OF BACTERIOLOGY

The Structure and Interactions of SpoIISA and SpoIISB, a Toxin-Antitoxin System inBacillus subtilis

(2010) Patrik Florek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

(2010) H. Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array

(2010) V. L. Arcus et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems

(2008) Linda Miallau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY