Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways

Persistence and resistance as complementary bacterial adaptations to antibiotics

(2016) T. Vogwill et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA

(2016) Angela M. Cheverton et al.   MOLECULAR CELL

The toxin GraT inhibits ribosome biogenesis

(2016) Andres Ainelo et al.   MOLECULAR MICROBIOLOGY

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria

(2016) Rebecca M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease

(2016) Shih-Chieh Su et al.   STRUCTURE

Structural Insights into the Allosteric Operation of the Lon AAA+ Protease

(2016) Chien-Chu Lin et al.   STRUCTURE

Toxin-Antitoxin Systems of Staphylococcus aureus

(2016) Christopher Schuster et al.   Toxins

Combatting bacterial persister cells

(2015) Thomas K. Wood   BIOTECHNOLOGY AND BIOENGINEERING

BtoxDB: A comprehensive database of protein structural data on toxin–antitoxin systems

(2015) Luiz Carlos Bertucci Barbosa et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Pseudomonas aeruginosa Lon and ClpXP proteases: roles in linking carbon catabolite repression system with quorum-sensing system

(2015) Nana Yang et al.   CURRENT GENETICS

Type II toxin: antitoxin systems. More than small selfish entities?

(2015) Andrea Rocker et al.   CURRENT GENETICS

Oxidative stress protection by polyphosphate—new roles for an old player

(2015) Michael J Gray et al.   CURRENT OPINION IN MICROBIOLOGY

Inactivation of Cell Division Protein FtsZ by SulA Makes Lon Indispensable for the Viability of a ppGpp0Strain of Escherichia coli

(2015) Aanisa Nazir et al.   JOURNAL OF BACTERIOLOGY

Stability of the GraA Antitoxin Depends on Growth Phase, ATP Level, and Global Regulator MexT

(2015) Hedvig Tamman et al.   JOURNAL OF BACTERIOLOGY

Expression of Stress and Virulence Genes in Escherichia coli O157:H7 Heat Shocked in Fresh Dairy Compost

(2015) RANDHIR SINGH et al.   JOURNAL OF FOOD PROTECTION

Unrelated toxin–antitoxin systems cooperate to induce persistence

(2015) Rick A. Fasani et al.   Journal of the Royal Society Interface

Remarkable Functional Convergence: Alarmone ppGpp Mediates Persistence by Activating Type I and II Toxin-Antitoxins

(2015) Kenn Gerdes et al.   MOLECULAR CELL

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

(2015) Natalie Verstraeten et al.   MOLECULAR CELL

Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine

(2015) Ohad Iosefson et al.   Nature Chemical Biology

Collective antibiotic tolerance: mechanisms, dynamics and intervention

(2015) Hannah R Meredith et al.   Nature Chemical Biology

Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines

(2015) Adrian O. Olivares et al.   NATURE REVIEWS MICROBIOLOGY

The Pfam protein families database: towards a more sustainable future

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Persisters unmasked

(2015) D. W. Holden   SCIENCE

Genetic Basis of Persister Tolerance to Aminoglycosides in Escherichia coli

(2015) Yue Shan et al.   mBio

Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria

(2015) Wilfried Moreira et al.   mBio

Orphan Toxin OrtT (YdcX) of Escherichia coli Reduces Growth during the Stringent Response

(2015) Sabina Islam et al.   Toxins

YoeB toxin is activated during thermal stress

(2015) Brian D. Janssen et al.   MicrobiologyOpen

The Fatty Acid Signaling Moleculecis-2-Decenoic Acid Increases Metabolic Activity and Reverts Persister Cells to an Antimicrobial-Susceptible State

(2014) Cláudia N. H. Marques et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Disorder- and Dynamics-Based Regulatory Mechanisms in Toxin–Antitoxin Modules

(2014) Remy Loris et al.   CHEMICAL REVIEWS

Role of Adaptor TrfA and ClpPC in Controlling Levels of SsrA-Tagged Proteins and Antitoxins in Staphylococcus aureus

(2014) N. P. Donegan et al.   JOURNAL OF BACTERIOLOGY

The ClpXP Protease Is Responsible for the Degradation of the Epsilon Antidote to the Zeta Toxin of the Streptococcal pSM19035 Plasmid

(2014) Iwona Brzozowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxin Kid uncouples DNA replication and cell division to enforce retention of plasmid R1 in Escherichia coli cells

(2014) B. Pimentel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis-Like Death, an Extreme SOS Response in Escherichia coli

(2014) A. Erental et al.   mBio

Toxin-Antitoxin Systems as Multilevel Interaction Systems

(2014) Nathalie Goeders et al.   Toxins

Regulating Toxin-Antitoxin Expression: Controlled Detonation of Intracellular Molecular Timebombs

(2014) Finbarr Hayes et al.   Toxins

Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems

(2014) Ralph Bertram et al.   Frontiers in Cellular and Infection Microbiology

Structural basis for DNA-mediated allosteric regulation facilitated by the AAA+module of Lon protease

(2014) Alan Yueh-Luen Lee et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Polyphosphate, cyclic AMP, guanosine tetraphosphate, and c-di-GMP reduce in vitro Lon activity

(2014) Devon O Osbourne et al.   Bioengineered

Arrested Protein Synthesis Increases Persister-Like Cell Formation

(2013) Brian W. Kwan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial Persister Cell Formation and Dormancy

(2013) Thomas K. Wood et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural overview of toxin–antitoxin systems in infectious bacteria: A target for developing antimicrobial agents

(2013) Sung Jean Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli

(2013) Villu Kasari et al.   BMC MICROBIOLOGY

Quantitative analysis of persister fractions suggests different mechanisms of formation among environmental isolates of E. coli

(2013) Niels Hofsteenge et al.   BMC MICROBIOLOGY

Proteotoxic Stress Induces a Cell-Cycle Arrest by Stimulating Lon to Degrade the Replication Initiator DnaA

(2013) Kristina Jonas et al.   CELL

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate

(2013) Christopher F. Schuster et al.   FEMS MICROBIOLOGY LETTERS

A Mutation in the N Domain of Escherichia coli Lon Stabilizes Dodecamers and Selectively Alters Degradation of Model Substrates

(2013) M. L. Wohlever et al.   JOURNAL OF BACTERIOLOGY

Energetic Basis of Uncoupling Folding from Binding for an Intrinsically Disordered Protein

(2013) Igor Drobnak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Bacterial Toxin Inhibits DNA Replication Elongation through a Direct Interaction with the β Sliding Clamp

(2013) Christopher D. Aakre et al.   MOLECULAR CELL

Killing the survivors

(2013) Kenn Gerdes et al.   NATURE

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Count-based differential expression analysis of RNA sequencing data using R and Bioconductor

(2013) Simon Anders et al.   Nature Protocols

Comparative genomics of defense systems in archaea and bacteria

(2013) Kira S. Makarova et al.   NUCLEIC ACIDS RESEARCH

Cleavage of the antitoxin of the parD toxin–antitoxin system is determined by the ClpAP protease and is modulated by the relative ratio of the toxin and the antitoxin

(2013) Elizabeth Diago-Navarro et al.   PLASMID

Regulation of toxin–antitoxin systems by proteolysis

(2013) Iwona Brzozowska et al.   PLASMID

Distinct quaternary structures of the AAA+ Lon protease control substrate degradation

(2013) E. F. Vieux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype

(2013) R. A. Fasani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed cell death in bacteria and implications for antibiotic therapy

(2013) Yu Tanouchi et al.   TRENDS IN MICROBIOLOGY

Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosis

(2013) Teresa Cortes et al.   Cell Reports

Bacterial Persistence and Toxin-Antitoxin Loci

(2012) Kenn Gerdes et al.   Annual Review of Microbiology

Involvement of the Lon Protease in the SOS Response Triggered by Ciprofloxacin in Pseudomonas aeruginosa PAO1

(2012) Elena B. M. Breidenstein et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

(2012) Kira S Makarova et al.   Biology Direct

Armand-Frappier Outstanding Student Award — Role of ATP-dependent proteases in antibiotic resistance and virulence

(2012) Elena B.M. Breidenstein et al.   CANADIAN JOURNAL OF MICROBIOLOGY

TAC from Mycobacterium tuberculosis: a paradigm for stress-responsive toxin–antitoxin systems controlled by SecB-like chaperones

(2012) Ambre Sala et al.   CELL STRESS & CHAPERONES

Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS

(2012) Xiaoxue Wang et al.   ENVIRONMENTAL MICROBIOLOGY

Characterization of Escherichia coli dinJ-yafQ Toxin-Antitoxin System Using Insights from Mutagenesis Data

(2012) J. Armalyte et al.   JOURNAL OF BACTERIOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Regulation of Enteric vapBC Transcription: Induction by VapC Toxin Dimer-Breaking

(2012) Kristoffer S. Winther et al.   NUCLEIC ACIDS RESEARCH

Regulation of the Escherichia coli HipBA Toxin-Antitoxin System by Proteolysis

(2012) Sonja Hansen et al.   PLoS One

Reverting Antibiotic Tolerance of Pseudomonas aeruginosa PAO1 Persister Cells by (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one

(2012) Jiachuan Pan et al.   PLoS One

The Crystal Structure of the Intact E. coli RelBE Toxin-Antitoxin Complex Provides the Structural Basis for Conditional Cooperativity

(2012) Andreas Bøggild et al.   STRUCTURE

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

(2012) Julia J. Williams et al.   TRENDS IN MICROBIOLOGY

New-found fundamentals of bacterial persistence

(2012) Cyrielle I. Kint et al.   TRENDS IN MICROBIOLOGY

Two Programmed Cell Death Systems in Escherichia coli: An Apoptotic-Like Death Is Inhibited by the mazEF-Mediated Death Pathway

(2012) Ariel Erental et al.   PLOS BIOLOGY

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Toxin-Antitoxin Systems in Bacteria and Archaea

(2011) Yoshihiro Yamaguchi et al.   Annual Review of Genetics

Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

(2011) Xiaoxue Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Persistence: mechanisms for triggering and enhancing phenotypic variability

(2011) NQ Balaban   CURRENT OPINION IN GENETICS & DEVELOPMENT

Heterogeneous bacterial persisters and engineering approaches to eliminate them

(2011) Kyle R Allison et al.   CURRENT OPINION IN MICROBIOLOGY

Prevalence and Significance of Plasmid Maintenance Functions in the Virulence Plasmids of Pathogenic Bacteria

(2011) Manjistha Sengupta et al.   INFECTION AND IMMUNITY

Bacterial Toxin RelE Mediates Frequent Codon-independent mRNA Cleavage from the 5′ End of Coding Regionsin Vivo

(2011) Jennifer M. Hurley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families

(2011) Raphaël Leplae et al.   NUCLEIC ACIDS RESEARCH

SecB-like chaperone controls a toxin-antitoxin stress-responsive system in Mycobacterium tuberculosis

(2011) P. Bordes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

A Conserved Mode of Protein Recognition and Binding in a ParD−ParE Toxin−Antitoxin Complex

(2010) Kevin M. Dalton et al.   BIOCHEMISTRY

Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

(2010) Dominic Him Shun Li et al.   CHEMISTRY & BIOLOGY

Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD

(2010) Younghoon Kim et al.   ENVIRONMENTAL MICROBIOLOGY

The Three Vibrio cholerae Chromosome II-Encoded ParE Toxins Degrade Chromosome I following Loss of Chromosome II

(2010) J. Yuan et al.   JOURNAL OF BACTERIOLOGY

TADB: a web-based resource for Type 2 toxin–antitoxin loci in bacteria and archaea

(2010) Yucheng Shao et al.   NUCLEIC ACIDS RESEARCH

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

(2010) Eitan Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of Phd-Doc, HigA, and YeeU Establish Multiple Evolutionary Links between Microbial Growth-Regulating Toxin-Antitoxin Systems

(2010) Mark A. Arbing et al.   STRUCTURE

Lon Protease Is Essential for Paradoxical Survival of Escherichia coli Exposed to High Concentrations of Quinolone

(2009) M. Malik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Chromosomal Toxin Gene yafQ Is a Determinant of Multidrug Tolerance for Escherichia coli Growing in a Biofilm

(2009) J. J. Harrison et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Proteolytic Regulation of Toxin-Antitoxin Systems by ClpPC in Staphylococcus aureus

(2009) N. P. Donegan et al.   JOURNAL OF BACTERIOLOGY

RelB and RelE of Escherichia coli Form a Tight Complex That Represses Transcription via the Ribbon–Helix–Helix Motif in RelB

(2009) Martin Overgaard et al.   JOURNAL OF MOLECULAR BIOLOGY

Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage

(2009) Meredith H. Prysak et al.   MOLECULAR MICROBIOLOGY

Three new RelE-homologous mRNA interferases ofEscherichia colidifferentially induced by environmental stresses

(2009) Mikkel Christensen-Dalsgaard et al.   MOLECULAR MICROBIOLOGY

A Differential Effect of E. coli Toxin-Antitoxin Systems on Cell Death in Liquid Media and Biofilm Formation

(2009) Ilana Kolodkin-Gal et al.   PLoS One

Proteolysis in the SOS response and metal homeostasis in Escherichia coli

(2009) Mihaela Pruteanu et al.   RESEARCH IN MICROBIOLOGY

Regulation and quality control by Lon-dependent proteolysis

(2009) Laurence Van Melderen et al.   RESEARCH IN MICROBIOLOGY

Degradation of cytoplasmic substrates by FtsH, a membrane-anchored protease with many talents

(2009) Franz Narberhaus et al.   RESEARCH IN MICROBIOLOGY

Temperature-dependent proteolysis as a control element in Escherichia coli metabolism

(2009) Chen Katz et al.   RESEARCH IN MICROBIOLOGY

Bacterial Toxin–Antitoxin Systems: More Than Selfish Entities?

(2009) Laurence Van Melderen et al.   PLoS Genetics

Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates

(2008) Irene Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

HicA of Escherichia coli Defines a Novel Family of Translation-Independent mRNA Interferases in Bacteria and Archaea

(2008) M. G. Jorgensen et al.   JOURNAL OF BACTERIOLOGY

Single-cell protein induction dynamics reveals a period of vulnerability to antibiotics in persister bacteria

(2008) O. Gefen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA