Structural and functional studies of theMycobacterium tuberculosisVapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides

Toxin-antitoxinvapBClocus participates in formation of the dormant state inMycobacterium smegmatis

(2014) Oksana I. Demidenok et al.   FEMS MICROBIOLOGY LETTERS

Structural basis ofBacillus anthracisMoxXT disruption and the modulation of MoxT ribonuclease activity by rationally designed peptides

(2014) Shashikala Verma et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin–antitoxin assembly

(2014) Uddipan Das et al.   JOURNAL OF STRUCTURAL BIOLOGY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Structural overview of toxin–antitoxin systems in infectious bacteria: A target for developing antimicrobial agents

(2013) Sung Jean Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae

(2012) Dabin Ren et al.   BMC MICROBIOLOGY

A VapBC Toxin-Antitoxin Module Is a Posttranscriptional Regulator of Metabolic Flux in Mycobacteria

(2012) J. L. McKenzie et al.   JOURNAL OF BACTERIOLOGY

Growth and Translation Inhibition through Sequence-specific RNA Binding byMycobacterium tuberculosisVapC Toxin

(2012) Jared D. Sharp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex fromM. tuberculosisreveals a Mg2+ion in the active site and a putative RNA-binding site

(2012) Andrew B. Min et al.   PROTEIN SCIENCE

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

(2012) Julia J. Williams et al.   TRENDS IN MICROBIOLOGY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

(2011) Xiaoxue Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Totally Drug-Resistant Tuberculosis in India

(2011) Z. F. Udwadia et al.   CLINICAL INFECTIOUS DISEASES

Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly

(2011) Christian Dienemann et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of growth and death in Escherichia coli by toxin–antitoxin systems

(2011) Yoshihiro Yamaguchi et al.   NATURE REVIEWS MICROBIOLOGY

Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis

(2011) María J. Maté et al.   NUCLEIC ACIDS RESEARCH

VapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins

(2011) Bintou Ahmadou Ahidjo et al.   PLoS One

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VapC6, a ribonucleolytic toxin regulates thermophilicity in the crenarchaeote Sulfolobus solfataricus

(2011) Y. Maezato et al.   RNA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array

(2010) V. L. Arcus et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The Structural Basis of Peptide-Protein Binding Strategies

(2010) Nir London et al.   STRUCTURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Emergence of New Forms of Totally Drug-Resistant Tuberculosis Bacilli

(2009) Ali Akbar Velayati et al.   CHEST

PemK Toxin ofBacillus anthracisIs a Ribonuclease

(2009) Shivangi Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The vapBC Operon from Mycobacterium smegmatis Is An Autoregulated Toxin–Antitoxin Module That Controls Growth via Inhibition of Translation

(2009) Jennifer Robson et al.   JOURNAL OF MOLECULAR BIOLOGY

Ectopic production of VapCs fromEnterobacteriainhibits translation andtrans-activates YoeB mRNA interferase

(2009) Kristoffer S. Winther et al.   MOLECULAR MICROBIOLOGY

A toxin–antitoxin module as a target for antimicrobial development

(2009) Virginia S. Lioy et al.   PLASMID

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems

(2008) Linda Miallau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of PAE0151 fromPyrobaculum aerophilum, a PIN-domain (VapC) protein from a toxin-antitoxin operon

(2008) Richard D. Bunker et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS