Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides

VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation

(2016) Kristoffer Winther et al.   NUCLEIC ACIDS RESEARCH

Recent Progress on Pyrazole Scaffold-Based Antimycobacterial Agents

(2015) Rangappa S. Keri et al.   ARCHIV DER PHARMAZIE

Compounds for use in the treatment of mycobacterial infections: a patent evaluation (WO2014049107A1)

(2015) Dany Pechalrieu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Type II toxin–antitoxin systems are unevenly distributed among Escherichia coli phylogroups

(2015) Krzysztof Fiedoruk et al.   MICROBIOLOGY-SGM

Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism

(2015) Haiyan Zhao et al.   NUCLEIC ACIDS RESEARCH

Structural and functional studies of theMycobacterium tuberculosisVapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides

(2015) In-Gyun Lee et al.   NUCLEIC ACIDS RESEARCH

Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase

(2015) Jonathan W. Cruz et al.   Nature Communications

YoeB toxin is activated during thermal stress

(2015) Brian D. Janssen et al.   MicrobiologyOpen

Mycobacterium tuberculosis Type II Toxin-Antitoxin Systems: Genetic Polymorphisms and Functional Properties and the Possibility of Their Use for Genotyping

(2015) Marina V. Zaychikova et al.   PLoS One

Toxin-antitoxinvapBClocus participates in formation of the dormant state inMycobacterium smegmatis

(2014) Oksana I. Demidenok et al.   FEMS MICROBIOLOGY LETTERS

Structural basis ofBacillus anthracisMoxXT disruption and the modulation of MoxT ribonuclease activity by rationally designed peptides

(2014) Shashikala Verma et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin–antitoxin assembly

(2014) Uddipan Das et al.   JOURNAL OF STRUCTURAL BIOLOGY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

VapC from the Leptospiral VapBC Toxin-Antitoxin Module Displays Ribonuclease Activity on the Initiator tRNA

(2014) Alexandre P. Y. Lopes et al.   PLoS One

Analysis of Non-Typeable Haemophilous influenzae VapC1 Mutations Reveals Structural Features Required for Toxicity and Flexibility in the Active Site

(2014) Brooke Hamilton et al.   PLoS One

Toxin-Antitoxin Systems as Multilevel Interaction Systems

(2014) Nathalie Goeders et al.   Toxins

Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis

(2014) Ambre Sala et al.   Toxins

β-Arm flexibility of HU fromStaphylococcus aureusdictates the DNA-binding and recognition mechanism

(2014) Do-Hee Kim et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Protein expression, crystallization and preliminary X-ray crystallographic analysis of the isolatedShigella flexneriVapC toxin

(2013) Kehan Xu et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Structural overview of toxin–antitoxin systems in infectious bacteria: A target for developing antimicrobial agents

(2013) Sung Jean Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

iPPI-DB: a manually curated and interactive database of small non-peptide inhibitors of protein–protein interactions

(2013) Céline M. Labbé et al.   DRUG DISCOVERY TODAY

The effect of limited proteolysis by different proteases on the formation of whey protein fibrils

(2013) Yu-Zhe Gao et al.   JOURNAL OF DAIRY SCIENCE

A Bacterial Toxin Inhibits DNA Replication Elongation through a Direct Interaction with the β Sliding Clamp

(2013) Christopher D. Aakre et al.   MOLECULAR CELL

Analysis Tool Web Services from the EMBL-EBI

(2013) Hamish McWilliam et al.   NUCLEIC ACIDS RESEARCH

Regulation of toxin–antitoxin systems by proteolysis

(2013) Iwona Brzozowska et al.   PLASMID

Conformational changes in DNA-binding proteins: Relationships with precomplex features and contributions to specificity and stability

(2013) Munazah Andrabi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Functional Role of the Sarcin–Ricin Loop of the 23S rRNA in the Elongation Cycle of Protein Synthesis

(2012) Xinying Shi et al.   JOURNAL OF MOLECULAR BIOLOGY

The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex fromM. tuberculosisreveals a Mg2+ion in the active site and a putative RNA-binding site

(2012) Andrew B. Min et al.   PROTEIN SCIENCE

Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry

(2012) J. L. McKenzie et al.   RNA

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

(2012) Julia J. Williams et al.   TRENDS IN MICROBIOLOGY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Toxin-Antitoxin Systems in Bacteria and Archaea

(2011) Yoshihiro Yamaguchi et al.   Annual Review of Genetics

Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

(2011) Xiaoxue Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Toxins-antitoxins: diversity, evolution and function

(2011) Finbarr Hayes et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity

(2011) Tom J Petty et al.   EMBO JOURNAL

Modeling of the structure and interactions of the B. anthracis antitoxin, MoxX: deletion mutant studies highlight its modular structure and repressor function

(2011) Nikita Chopra et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly

(2011) Christian Dienemann et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

(2011) Young-Woo Kim et al.   Nature Protocols

Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis

(2011) María J. Maté et al.   NUCLEIC ACIDS RESEARCH

VapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins

(2011) Bintou Ahmadou Ahidjo et al.   PLoS One

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Portrayal of Complex Dynamic Properties of Sugarcane Defensin 5 by NMR: Multiple Motions Associated with Membrane Interaction

(2011) Viviane Silva de Paula et al.   STRUCTURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

2Struc: the secondary structure server

(2010) D. P. Klose et al.   BIOINFORMATICS

Toxin–antitoxin systems: why so many, what for?

(2010) Laurence Van Melderen   CURRENT OPINION IN MICROBIOLOGY

How Can Hydrophobic Association Be Enthalpy Driven?

(2010) Piotr Setny et al.   Journal of Chemical Theory and Computation

TADB: a web-based resource for Type 2 toxin–antitoxin loci in bacteria and archaea

(2010) Yucheng Shao et al.   NUCLEIC ACIDS RESEARCH

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array

(2010) V. L. Arcus et al.   PROTEIN ENGINEERING DESIGN & SELECTION

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PemK Toxin ofBacillus anthracisIs a Ribonuclease

(2009) Shivangi Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Local combinational variables: an approach used in DNA-binding helix-turn-helix motif prediction with sequence information

(2009) Wenwei Xiong et al.   NUCLEIC ACIDS RESEARCH

A toxin–antitoxin module as a target for antimicrobial development

(2009) Virginia S. Lioy et al.   PLASMID

A Reexamination of Correlations of Amino Acids with Particular Secondary Structures

(2009) Saša N. Malkov et al.   PROTEIN JOURNAL

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems

(2008) Linda Miallau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Mycobacterium tuberculosis YefM Antitoxin Reveals that it is Not an Intrinsically Unstructured Protein

(2008) Pramod Kumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein–DNA interactions: structural, thermodynamic and clustering patterns of conserved residues in DNA-binding proteins

(2008) Shandar Ahmad et al.   NUCLEIC ACIDS RESEARCH