Monitoring proteolytic processing events by quantitative mass spectrometry

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The kallikrein-related peptidase family: Dysregulation and functions during cancer progression

(2016) T. Kryza et al.   BIOCHIMIE

Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration

(2016) Zhenyu Cai et al.   CELL RESEARCH

Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity

(2016) Donna Lee M. Dinnes et al.   FASEB JOURNAL

Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1

(2016) Ruth A. Fuhrman-Luck et al.   JOURNAL OF PROTEOME RESEARCH

Analyses of Histone Proteoforms Using Front-end Electron Transfer Dissociation-enabled Orbitrap Instruments

(2016) Lissa C. Anderson et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics

(2016) Martin L. Biniossek et al.   MOLECULAR & CELLULAR PROTEOMICS

Cathepsin B Expression and the Correlation with Clinical Aspects of Oral Squamous Cell Carcinoma

(2016) Wei-En Yang et al.   PLoS One

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors

(2016) Anna Prudova et al.   Cell Reports

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

(2016) Peer-Hendrik Kuhn et al.   eLife

Low Proteolytic Clipping of Histone H3 in Cervical Cancer

(2016) Jorge Sandoval-Basilio et al.   Journal of Cancer

Proteomic Substrate Identification for Membrane Proteases in the Brain

(2016) Stephan A. Müller et al.   Frontiers in Molecular Neuroscience

The beneficial role of proteolysis in skeletal muscle growth and stress adaptation

(2016) Ryan A. V. Bell et al.   Skeletal Muscle

Proteomic approaches to uncover MMP function

(2015) Pascal Schlage et al.   MATRIX BIOLOGY

Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns

(2015) Andrey Tvardovskiy et al.   MOLECULAR & CELLULAR PROTEOMICS

Twenty years of theMEROPSdatabase of proteolytic enzymes, their substrates and inhibitors

(2015) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

(2015) Theo Klein et al.   Nature Communications

Histone proteolysis: A proposal for categorization into ‘clipping’ and ‘degradation’

(2014) Maarten Dhaenens et al.   BIOESSAYS

Quantitative Proteomics to Characterize Specific Histone H2A Proteolysis in Chronic Lymphocytic Leukemia and the Myeloid THP-1 Cell Line

(2014) Pieter Glibert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Substrate Specificities of the Granzyme Tryptases A and K

(2014) Kim Plasman et al.   JOURNAL OF PROTEOME RESEARCH

Proteolytic clipping of histone tails: the emerging role of histone proteases in regulation of various biological processes

(2014) Gajendra Kumar Azad et al.   MOLECULAR BIOLOGY REPORTS

Middle-down hybrid chromatography/tandem mass spectrometry workflow for characterization of combinatorial post-translational modifications in histones

(2014) Simone Sidoli et al.   PROTEOMICS

Histone H3.3 and its proteolytically processed form drive a cellular senescence programme

(2014) Luis F. Duarte et al.   Nature Communications

Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity

(2013) Jin Ye   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Systematic Proteomic Analysis Identifies β-Site Amyloid Precursor Protein Cleaving Enzyme 2 and 1 (BACE2 and BACE1) Substrates in Pancreatic β-Cells

(2013) Ina Stützer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Revealsin VivoRoles in Cellular Homeostasis and Energy Metabolism

(2013) Claire H. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Post-translational Modification of Proteins: Proteomic Tools and Methodology

(2013) Lindsay D. Rogers et al.   MOLECULAR & CELLULAR PROTEOMICS

Cathepsin B as a potential prognostic and therapeutic marker for human lung squamous cell carcinoma

(2013) Fengming Gong et al.   Molecular Cancer

Identification and interrogation of combinatorial histone modifications

(2013) Kelly R. Karch et al.   Frontiers in Genetics

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

(2012) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Biochemical Characterization and N-terminomics Analysis of Leukolysin, the Membrane-type 6 Matrix Metalloprotease (MMP25)

(2012) Amanda E. Starr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global identification of peptidase specificity by multiplex substrate profiling

(2012) Anthony J O'Donoghue et al.   NATURE METHODS

Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry

(2012) Michael A Gillette et al.   NATURE METHODS

Profiling protease activities by dynamic proteomics workflows

(2012) Diana Klingler et al.   PROTEOMICS

Mass spectrometry-based proteomics strategies for protease cleavage site identification

(2012) Bart H. J. van den Berg et al.   PROTEOMICS

Proteases in autophagy

(2011) Vitaliy Kaminskyy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites

(2011) Oliver Schilling et al.   BIOLOGICAL CHEMISTRY

Comprehensive Analysis of Protein Modifications by Top-Down Mass Spectrometry

(2011) Han Zhang et al.   Circulation-Cardiovascular Genetics

Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates

(2011) Oded Kleifeld et al.   Nature Protocols

Selecting protein N-terminal peptides by combined fractional diagonal chromatography

(2011) An Staes et al.   Nature Protocols

Plasma Kallikrein and Diabetic Macular Edema

(2010) Edward P. Feener   Current Diabetes Reports

Biological role of matrix metalloproteinases: a critical balance

(2010) S. Loffek et al.   EUROPEAN RESPIRATORY JOURNAL

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

(2010) Chrisostomi Gialeli et al.   FEBS Journal

Multiplex N-terminome Analysis of MMP-2 and MMP-9 Substrate Degradomes by iTRAQ-TAILS Quantitative Proteomics

(2010) Anna Prudova et al.   MOLECULAR & CELLULAR PROTEOMICS

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

(2010) Bart De Strooper   PHYSIOLOGICAL REVIEWS

Sampling the N-terminal proteome of human blood

(2010) D. Wildes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MS-driven protease substrate degradomics

(2010) Francis Impens et al.   PROTEOMICS

Emerging roles of mitochondrial proteases in neurodegeneration

(2009) Paola Martinelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

What does the future hold for top down mass spectrometry?

(2009) Benjamin A. Garcia   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N Termini

(2008) Sami Mahrus et al.   CELL

Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation

(2008) Elizabeth M. Duncan et al.   CELL

Global Mapping of the Topography and Magnitude of Proteolytic Events in Apoptosis

(2008) Melissa M. Dix et al.   CELL

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease proteomics: Revealing protease in vivo functions using systems biology approaches

(2008) A DOUCET et al.   MOLECULAR ASPECTS OF MEDICINE

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

(2008) Oliver Schilling et al.   NATURE BIOTECHNOLOGY

Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40

(2008) J.Y. Huang et al.   NEUROSCIENCE