Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies

(2016) Camille Guillerey et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

(2016) Maria Pia Abruzzese et al.   Journal of Hematology & Oncology

Human CD56brightNK Cells: An Update

(2016) Tatiana Michel et al.   JOURNAL OF IMMUNOLOGY

Exosomes for Immunoregulation and Therapeutic Intervention in Cancer

(2016) Xuan Zhang et al.   Journal of Cancer

Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells

(2016) Fabrizio Antonangeli et al.   OncoImmunology

RIG-I activation induces the release of extracellular vesicles with antitumor activity

(2016) Juliane Daßler-Plenker et al.   OncoImmunology

Adjuvant for vaccine immunotherapy of cancer - focusing on Toll-like receptor 2 and 3 agonists for safely enhancing antitumor immunity

(2015) Tsukasa Seya et al.   CANCER SCIENCE

Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions

(2015) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells

(2015) Alessandra Zingoni et al.   JOURNAL OF IMMUNOLOGY

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer

(2015) Jessica Gobbo et al.   JNCI-Journal of the National Cancer Institute

Differential expression of ligands for NKG2D and DNAM-1 receptors by epithelial ovarian cancer-derived exosomes and its influence on NK cell cytotoxicity

(2015) Alireza Labani-Motlagh et al.   TUMOR BIOLOGY

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

(2015) Cinzia Fionda et al.   Oncotarget

NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma

(2015) Cinzia Fionda et al.   Biomed Research International

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer

(2015) Jessica Gobbo et al.   JNCI-Journal of the National Cancer Institute

Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer

(2015) Sophie Gunther et al.   Frontiers in Immunology

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

The exosomes in tumor immunity

(2015) Yanfang Liu et al.   OncoImmunology

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

(2015) Guy Berchem et al.   OncoImmunology

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

(2014) T. Umezu et al.   BLOOD

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Heat Shock Protein 70, Released from Heat-Stressed Tumor Cells, Initiates Antitumor Immunity by Inducing Tumor Cell Chemokine Production and Activating Dendritic Cells via TLR4 Pathway

(2014) T. Chen et al.   JOURNAL OF IMMUNOLOGY

The Natural Product Phyllanthusmin C Enhances IFN-γ Production by Human NK Cells through Upregulation of TLR-Mediated NF-κB Signaling

(2014) Youcai Deng et al.   JOURNAL OF IMMUNOLOGY

Dynamic light scattering for the characterization and counting of extracellular vesicles: a powerful noninvasive tool

(2014) Valentina Palmieri et al.   JOURNAL OF NANOPARTICLE RESEARCH

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB

(2014) Amy Chow et al.   Scientific Reports

The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells

(2014) Cristina Cerboni et al.   Frontiers in Immunology

Role of Exosomes Released by Dendritic Cells and/or by Tumor Targets: Regulation of NK Cell Plasticity

(2014) Katrin S. Reiners et al.   Frontiers in Immunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Exosomes and communication between tumours and the immune system: are all exosomes equal?

(2013) Angélique Bobrie et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MicroRNAs activate natural killer cells through Toll-like receptor signaling

(2013) S. He et al.   BLOOD

Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity

(2013) K. S. Reiners et al.   BLOOD

TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals

(2013) Minou Adib-Conquy et al.   IMMUNOLOGY AND CELL BIOLOGY

The Yin and Yang of Toll-like receptors in cancer

(2013) J-P Pradere et al.   ONCOGENE

Interaction ofMycobacterium tuberculosisCell Wall Components with the Human Natural Killer Cell Receptors NKp44 and Toll-Like Receptor 2

(2013) S. Esin et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Syk-dependent regulation of Hrs phosphorylation and ubiquitination upon FcεRI engagement: Impact on Hrs membrane/cytosol localization

(2012) Francesca Gasparrini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responsesin Vitro

(2012) Li-Hong Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of natural killer cells in immunity against multiple myeloma

(2012) James Godfrey et al.   LEUKEMIA & LYMPHOMA

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trial watch

(2012) Erika Vacchelli et al.   OncoImmunology

Peptides and Aptamers Targeting HSP70: A Novel Approach for Anticancer Chemotherapy

(2011) Anne-Laure Rérole et al.   CANCER RESEARCH

Extracellular Heat Shock Protein 70 Induces Cardiomyocyte Inflammation and Contractile Dysfunction via TLR2

(2011) Sumeet Mathur et al.   CIRCULATION JOURNAL

TLR2 Agonist PSK Activates Human NK Cells and Enhances the Antitumor Effect of HER2-Targeted Monoclonal Antibody Therapy

(2011) H. Lu et al.   CLINICAL CANCER RESEARCH

Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes

(2010) O. Ashiru et al.   CANCER RESEARCH

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of direct and indirect TLR-mediated activation of human NK cells by low molecular weight dextran sulfate

(2010) Anne-Laure Millard et al.   MOLECULAR IMMUNOLOGY

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

(2010) S. Stangl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8+ CTL- and NK-mediated antitumour immunity than exosomes released from heat-shocked tumour cells expressing cytoplasmic HSP70

(2009) Yufeng Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

(2008) A. Soriani et al.   BLOOD