MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications

The clinical potential of adipogenesis and obesity-related microRNAs

(2018) M. Zaiou et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice

(2017) Malte Kölling et al.   MOLECULAR THERAPY

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Oligonucleotide Therapeutics — A New Class of Cholesterol-Lowering Drugs

(2017) Anastasia Khvorova   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of brown and beige fat by microRNAs

(2017) Yong Chen et al.   PHARMACOLOGY & THERAPEUTICS

Neonatal Diabetes and the K ATP Channel: From Mutation to Therapy

(2017) Frances M. Ashcroft et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

MicroRNAs in adipocyte formation and obesity

(2016) Marcel Scheideler   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Strategies to use microRNAs as therapeutic targets

(2016) Jan Krützfeldt   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs

(2016) Jie-Mei Wang et al.   DIABETES

Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a

(2016) Basak Icli et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy

(2016) Mitsuo Kato et al.   Nature Communications

MicroRNAs as regulators of beta-cell function and dysfunction

(2015) Mirwais Osmai et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets

(2015) Ksenia Tugay et al.   DIABETOLOGIA

Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice

(2015) Anna Motterle et al.   DIABETOLOGIA

Genes associated with diabetes: potential for novel therapeutic targets?

(2015) Kazuo Hara et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids

(2015) Xianghui Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

(2015) Ulrike Flierl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Noncoding RNAs in diabetes vascular complications

(2015) Cristina Beltrami et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Maturity-onset diabetes of the young (MODY): an update

(2015) Ahmet Anık et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Contribution of Intronic miR-338–3p and Its Hosting Gene AATK to Compensatory β-Cell Mass Expansion

(2015) Cécile Jacovetti et al.   MOLECULAR ENDOCRINOLOGY

The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

(2015) Bengt-Frederik Belgardt et al.   NATURE MEDICINE

A piece of the pi(e): The diverse roles of animal piRNAs and their PIWI partners

(2015) Robyn S.M. Lim et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning

(2015) Cécile Jacovetti et al.   Nature Communications

A Universal Aptamer Chimera for the Delivery of Functional microRNA-126

(2015) Jan-H. Rohde et al.   Nucleic Acid Therapeutics

MicroRNAs in renal fibrosis

(2015) Arthur C.-K. Chung et al.   Frontiers in Physiology

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion

(2014) Guido Sebastiani et al.   ACTA DIABETOLOGICA

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

(2014) Thomas R. Cech et al.   CELL

Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets

(2014) Vasumathi Kameswaran et al.   Cell Metabolism

miR-195 regulates SIRT1-mediated changes in diabetic retinopathy

(2014) Rokhsana Mortuza et al.   DIABETOLOGIA

Development of microRNA therapeutics is coming of age

(2014) E. van Rooij et al.   EMBO Molecular Medicine

tRNA fragments in human health and disease

(2014) Paul Anderson et al.   FEBS LETTERS

MicroRNA-7a regulates pancreatic β cell function

(2014) Mathieu Latreille et al.   JOURNAL OF CLINICAL INVESTIGATION

The rise of regulatory RNA

(2014) Kevin V. Morris et al.   NATURE REVIEWS GENETICS

Regulation of metabolism by long, non-coding RNAs

(2014) Jan-Wilhelm Kornfeld et al.   Frontiers in Genetics

MicroRNA miR-27b Rescues Bone Marrow–Derived Angiogenic Cell Function and Accelerates Wound Healing in Type 2 Diabetes Mellitus

(2013) Jie-Mei Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

lincRNAs: Genomics, Evolution, and Mechanisms

(2013) Igor Ulitsky et al.   CELL

Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell

(2013) Sudhir G. Tattikota et al.   Cell Metabolism

microRNA in the development of diabetic complications

(2013) Aaron D. McClelland et al.   CLINICAL SCIENCE

Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

(2013) Valeria Nesca et al.   DIABETOLOGIA

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

(2013) Jan-Wilhelm Kornfeld et al.   NATURE

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

MicroRNA biogenesis: regulating the regulators

(2012) Emily F. Finnegan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Changes in MicroRNA Expression Contribute to Pancreatic  -Cell Dysfunction in Prediabetic NOD Mice

(2012) E. Roggli et al.   DIABETES

Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity

(2012) B. Zhou et al.   DIABETOLOGIA

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

(2012) Cécile Jacovetti et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibiting MicroRNA-192 Ameliorates Renal Fibrosis in Diabetic Nephropathy

(2012) S. Putta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

(2012) Eva van Rooij et al.   NATURE REVIEWS DRUG DISCOVERY

Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells

(2012) Masaki Mori et al.   PLOS BIOLOGY

An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

(2012) Samantha E Wilner et al.   Molecular Therapy-Nucleic Acids

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia

(2011) Andrea Caporali et al.   CIRCULATION

Diabetes Complications: The MicroRNA Perspective

(2011) P. Kantharidis et al.   DIABETES

MicroRNA-200b Regulates Vascular Endothelial Growth Factor-Mediated Alterations in Diabetic Retinopathy

(2011) K. McArthur et al.   DIABETES

MicroRNA-29c Is a Signature MicroRNA under High Glucose Conditions That Targets Sprouty Homolog 1, and Itsin VivoKnockdown Prevents Progression of Diabetic Nephropathy

(2011) Jianyin Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells

(2011) Mitsuo Kato et al.   KIDNEY INTERNATIONAL

Alternative miRNA Biogenesis Pathways and the Interpretation of Core miRNA Pathway Mutants

(2011) Jr-Shiuan Yang et al.   MOLECULAR CELL

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

(2011) Sabine D. Jordan et al.   NATURE CELL BIOLOGY

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Altered MicroRNA Expression Profiles in Retinas with Diabetic Retinopathy

(2011) Jin-hui Wu et al.   OPHTHALMIC RESEARCH

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

(2011) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gestational diabetes: risk factors and recent advances in its genetics and treatment

(2010) Clive J. Petry   BRITISH JOURNAL OF NUTRITION

Structure and activity of putative intronic miRNA promoters

(2010) A. M. Monteys et al.   RNA

Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes

(2010) Iain J Gallagher et al.   Genome Medicine

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Differential expression of microRNAs in mouse liver under aberrant energy metabolic status

(2009) Shengjie Li et al.   JOURNAL OF LIPID RESEARCH

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet

(2008) Rieko Takanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy

(2008) Qiang Wang et al.   FASEB JOURNAL