Recent developments with rhodanine as a scaffold for drug discovery

Diversity-oriented catalyst-free synthesis of pseudopeptides containing rhodanine scaffolds via a one-pot sequential isocyanide-based six-component reactions in water using ultrasound irradiation

(2018) Ahmad Shaabani et al.   ULTRASONICS SONOCHEMISTRY

Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation

(2017) Dnyaneshwar D. Subhedar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

5-Ene-4-thiazolidinones – An efficient tool in medicinal chemistry

(2017) Danylo Kaminskyy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Spectral Characteristic and Preliminary Anticancer Activity in vitro of Selected Rhodanine-3-carboxylic Acids Derivatives

(2017) Iwona Stawoska et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids

(2017) Waldemar Tejchman et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and Bioactivity Evaluation of N-Arylsulfonylindole Analogs Bearing a Rhodanine Moiety as Antibacterial Agents

(2017) et al.   MOLECULES

One-Pot Synthesis of 5-Ene-4-aminothiazol-2(5H)-ones and Chromeno[2,3-d]thiazol-2-ones

(2017) Roman Lesyk et al.   SYNLETT

Synthesis and effect on SMMC-7721 cells of new benzo[ c , d ]indole rhodanine complex merocyanines as PDT photosensitizers

(2017) Mengqi Yan et al.   TETRAHEDRON

Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives

(2017) Guang-cheng Wang et al.   MedChemComm

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

(2017) Javier Egea et al.   Redox Biology

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

(2016) S. Vatolin et al.   CANCER RESEARCH

5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells

(2016) Julia Senkiv et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antifibrotic and anticancer action of 5-ene amino/iminothiazolidinones

(2016) Danylo Kaminskyy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hybrid molecules: The privileged scaffolds for various pharmaceuticals

(2016) Shaveta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions

(2016) Paul A. Jackson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Counting on natural products for drug design

(2016) Tiago Rodrigues et al.   Nature Chemistry

Focus on PAINS: false friends in the quest for selective anti-protozoal lead structures from Nature?

(2016) J. Glaser et al.   MedChemComm

Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action

(2015) Kyeojin Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Systematic Evaluation of the Metabolism and Toxicity of Thiazolidinone and Imidazolidinone Heterocycles

(2015) Shi Qing Tang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Xanthine oxidase inhibitory properties and anti-inflammatory activity of 2-amino-5-alkylidene-thiazol-4-ones

(2015) Zaklina Smelcerovic et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies

(2015) Renato A. Bauer   DRUG DISCOVERY TODAY

Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery

(2015) Adile Ayati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Furan-based benzene mono- and dicarboxylic acid derivatives as multiple inhibitors of the bacterial Mur ligases (MurC–MurF): experimental and computational characterization

(2015) Andrej Perdih et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS

(2015) Jayme L. Dahlin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

(2015) John L. Wallace et al.   NATURE REVIEWS DRUG DISCOVERY

One-Pot Three-Component Route for the Synthesis of Rhodanine Derivatives in Water

(2015) Azim Ziyaei Halimehjani et al.   SYNTHESIS-STUTTGART

A straightforward and sustainable one-pot, four-component synthesis of rhodanine derivatives

(2015) Najmedin Azizi et al.   TETRAHEDRON LETTERS

APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

(2015) N Mohell et al.   Cell Death & Disease

A molecular nematic liquid crystalline material for high-performance organic photovoltaics

(2015) Kuan Sun et al.   Nature Communications

Graphene oxide/rhodanine redox chemistry and its application in designing high-performance elastomer/graphene composites

(2015) Zhijun Yang et al.   RSC Advances

Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC–MurF)

(2014) Andrej Perdih et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

(2014) Mattia Mori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications

(2014) Yu Zhao et al.   CHEMICAL COMMUNICATIONS

A Crosslinker Based on a Tethered Electrophile for Mapping Kinase-Substrate Networks

(2014) Megan M. Riel-Mehan et al.   CHEMISTRY & BIOLOGY

4-Oxothiazolidines with Exocyclic C=C Double Bond(s): Synthesis, Structure, Reactions and Biological Activity

(2014) Milovan Stojanovic et al.   CURRENT ORGANIC CHEMISTRY

Synthesis of pyrazoline–thiazolidinone hybrids with trypanocidal activity

(2014) Dmytro Havrylyuk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells

(2014) Kothanahally S. Sharath Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Trends in research of antitrypanosomal agents among synthetic heterocycles

(2014) Anna Kryshchyshyn et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazolidine-2,4-diones as multi-targeted scaffold in medicinal chemistry: Potential anticancer agents

(2014) Vivek Asati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isothiocoumarin-3-carboxylic acid derivatives: Synthesis, anticancer and antitrypanosomal activity evaluation

(2014) Danylo Kaminskyy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A new dawn for the use of thiazolidinediones in cancer therapy

(2014) Hardik Joshi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

(2014) Jürgen Brem et al.   Nature Chemistry

2-Thioxothiazolidin-4-one (Rhodanine)

(2014) Khadijeh Hajibabaei   SYNLETT

Hydrogen sulfide donors in research and drug development

(2014) Zhi Jian Song et al.   MedChemComm

Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

(2013) Yoshinari Miyata et al.   ACS Chemical Neuroscience

Thiazolidine-2,4-diones: Progress towards multifarious applications

(2013) Viral S. Jain et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aminocatalyzed asymmetric Diels–Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives

(2013) Kailong Zhu et al.   CHEMICAL COMMUNICATIONS

The Thiol-Michael Addition Click Reaction: A Powerful and Widely Used Tool in Materials Chemistry

(2013) Devatha P. Nair et al.   CHEMISTRY OF MATERIALS

An efficient one-pot synthesis of novel isatin-based 2-amino thiazol-4-one conjugates using MgO nanoparticles in aqueous media

(2013) Robabeh Baharfar et al.   COMPTES RENDUS CHIMIE

Thiazoles and Thiazolidinones as Antioxidants

(2013) A.A. Geronikaki et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis and biological evaluation of a new class of 4-aminoquinoline–rhodanine hybrid as potent anti-infective agents

(2013) Kuldeep Chauhan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

4-Thiazolidinones: The advances continue…

(2013) Avinash C. Tripathi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Advances in the development of hybrid anticancer drugs

(2013) Sébastien Fortin et al.   Expert Opinion on Drug Discovery

The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress

(2013) O.P. Yelisyeyeva et al.   FOOD CHEMISTRY

How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo

(2013) Henry J. Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synthesis, Antifungal and Antitumor Activity of Novel (Z)-5-Hetarylmethylidene-1,3-thiazol-4-ones and (Z)-5-Ethylidene-1,3-thiazol-4-ones

(2013) Alberto Insuasty et al.   MOLECULES

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

(2013) Hemant Kumar et al.   NATURAL PRODUCT REPORTS

Photochemical activation of TRPA1 channels in neurons and animals

(2013) David Kokel et al.   Nature Chemical Biology

Synthesis and Antioxidant Activity Evaluation of Novel 5,7-dimethyl-3H-Thiazolo[4,5-B]Pyridines

(2013) Taras I. Chaban et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

5-Ethoxymethylidene-4-thioxo-2-thiazolidinone as Versatile Building Block for Novel Biorelevant Small Molecules with Thiopyrano[2,3-d][1,3]thiazole Core

(2013) Dmytro Atamanyuk et al.   SYNTHETIC COMMUNICATIONS

Facile Construction of Structurally Diverse Thiazolidinedione-Derived Compounds via Divergent Stereoselective Cascade Organocatalysis and Their Biological Exploratory Studies

(2013) Yongqiang Zhang et al.   ACS Combinatorial Science

Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase

(2012) Jo-Anne Pinson et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells

(2012) F. Esra Onen-Bayram et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent developments and biological activities of thiazolidinone derivatives: A review

(2012) Abhishek Kumar Jain et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents

(2012) Chang-Ji Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

(2012) Wenbin Wu et al.   CHEMICAL COMMUNICATIONS

Synthesis and antimicrobial evaluation of l-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone

(2012) Xin Jin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational design of apoptosis signal-regulating kinase 1 inhibitors: Discovering novel structural scaffold

(2012) Galyna P. Volynets et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation

(2012) Tihomir Tomašić et al.   Expert Opinion on Drug Discovery

An Efficient Synthesis of Thiazolidine-4-ones with Antitumor and Antioxidant Activities

(2012) Ashraf A. Aly et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis of New 4-Thiazolidinone-, Pyrazoline-, and Isatin-Based Conjugates with Promising Antitumor Activity

(2012) Dmytro Havrylyuk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Electrophilic natural products and their biological targets

(2012) Malte Gersch et al.   NATURAL PRODUCT REPORTS

Versatile Routes to Marine Sponge Metabolites through Benzylidene Rhodanines

(2012) Suresh K. Kottakota et al.   ORGANIC LETTERS

Asymmetric Michael Addition of Substituted Rhodanines to α,β-Unsaturated Ketones Catalyzed by Bulky Primary Amines

(2012) Feng Yu et al.   ORGANIC LETTERS

Synthesis of heterocycles by domino-Knoevenagel–hetero-Diels–Alder reactions

(2012) K.C. Majumdar et al.   TETRAHEDRON

Rhodanine carboxylic acids as novel inhibitors of histone acetyltransferases

(2012) Silviya D. Furdas et al.   MedChemComm

Rhodanine and Thiohydantoin Derivatives for Detecting Tau Pathology in Alzheimer’s Brains

(2011) Masahiro Ono et al.   ACS Chemical Neuroscience

Fragment based discovery of a novel and selective PI3 kinase inhibitor

(2011) Samantha J. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

(2011) Sangmi Oh et al.   CHEMICAL COMMUNICATIONS

Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents

(2011) Li-Li Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An efficient one-pot synthesis of dispiropyrrolidine derivatives through 1,3-dipolar cycloaddition reactions under ultrasound irradiation

(2011) Hai Liu et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

(2011) Thomas Mendgen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

(2011) Aikaterini Rousaki et al.   JOURNAL OF MOLECULAR BIOLOGY

Three-Component, One-Flask Synthesis of Rhodanines (Thiazolidinones)

(2011) Alexander M. Jacobine et al.   JOURNAL OF ORGANIC CHEMISTRY

Predicting Michael-acceptor reactivity and toxicity through quantum chemical transition-state calculations

(2011) Denis Mulliner et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An efficient method for the transformation of 5-ylidenerhodanines into 2,3,5-trisubstituted-4-thiazolidinones

(2011) Danylo Kaminskyy et al.   TETRAHEDRON LETTERS

An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?

(2010) Cristina Avonto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase

(2010) Tanaji T. Talele et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel rhodanine derivatives induce growth inhibition followed by apoptosis

(2010) Balaji T. Moorthy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prediction of Michael-Type Acceptor Reactivity toward Glutathione

(2010) Johannes A. H. Schwöbel et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity

(2010) Zhen-Hua Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety

(2010) Dmytro Havrylyuk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Observations on screening-based research and some concerning trends in the literature

(2010) Jonathan B Baell   Future Medicinal Chemistry

Synthesis and antifungal evaluation of novel dicyanoderivatives of rhodanine

(2010) Braulio Insuasty et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Discovery of Novel 5-Benzylidenerhodanine and 5-Benzylidenethiazolidine-2,4-dione Inhibitors of MurD Ligase

(2010) Nace Zidar et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and structure–activity relationship analysis of Staphylococcus aureus sortase A inhibitors

(2009) Nuttee Suree et al.   BIOORGANIC & MEDICINAL CHEMISTRY

First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness

(2009) Terry K. Smith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A convenient method for the synthesis of thiopyrano[4,3-c]quinoline, a new heterocyclic system

(2009) N. T. Pokhodylo et al.   Chemistry of Heterocyclic Compounds

Rhodanine as a Privileged Scaffold in Drug Discovery

(2009) T. Tomasic et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives

(2009) Danylo Kaminskyy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of (β-carboxyethyl)-rhodanine derivatives exhibiting peroxisome proliferator-activated receptor γ activity

(2009) Jiwon Choi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives

(2009) Marco Radi et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

A simple and effective approach to the synthesis of rhodanine derivatives via three-component reactions in water

(2009) Abdolali Alizadeh et al.   TETRAHEDRON LETTERS

Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity

(2009) Sudipta Saha et al.   TOXICOLOGY LETTERS

From Molecular Shape to Potent Bioactive Agents I: Bioisosteric Replacement of Molecular Fragments

(2008) Ewgenij Proschak et al.   ChemMedChem

Chemical Proteomics-Based Drug Design: Target and Antitarget Fishing with a Catechol−Rhodanine Privileged Scaffold for NAD(P)(H) Binding Proteins

(2008) Xia Ge et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Cytoselective Toxicity, Structure–Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells

(2008) Hongyu Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid−Glutamic Acid−Alanine−Aspartic Acid Box Polypeptide 3

(2008) Giovanni Maga et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epalrestat: An Aldose Reductase Inhibitor for the Treatment of Diabetic Neuropathy

(2008) Mary Ann Ramirez et al.   PHARMACOTHERAPY

A new domino-Knoevenagel–hetero-Diels–Alder reaction

(2008) Vasyl S. Matiychuk et al.   TETRAHEDRON LETTERS

Novel GSK-3β inhibitors from sequential virtual screening

(2007) Hye-Jung Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY